A5058434964- Endometrial and Cervical Cancer Treatments
- Cancer-related molecular mechanisms research
- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- MicroRNA in disease regulation
- Ovarian cancer diagnosis and treatment
- Reproductive System and Pregnancy
- Cytokine Signaling Pathways and Interactions
- Cancer Immunotherapy and Biomarkers
- Reproductive Physiology in Livestock
- Cancer Genomics and Diagnostics
- Circular RNAs in diseases
- Kruppel-like factors research
- Preterm Birth and Chorioamnionitis
- Sarcoma Diagnosis and Treatment
- Neonatal and Maternal Infections
- Genetic factors in colorectal cancer
- Prenatal Screening and Diagnostics
- Psoriasis: Treatment and Pathogenesis
- Colorectal and Anal Carcinomas
- RNA Research and Splicing
- Lung Cancer Research Studies
- Reproductive tract infections research
- Inflammatory Biomarkers in Disease Prognosis
- Cancer, Lipids, and Metabolism
Tianjin Medical University General Hospital
2018-2024
Qingdao Municipal Hospital
2024
Hebei General Hospital
2021
Uterine leiomyosarcoma (uLMS) is a rare but malignant gynaecological tumour with poor survival outcome. The present study was aimed at identifying the key genes and pathways in development of uLMS through bioinformatics analysis. To minimize frequency false-positive results analysis, 3 microarrays including GSE764, GSE64763 GSE68312 were downloaded from Gene Expression Omnibus (GEO). Differentially expressed (DEGs) screened out using online tool GEO2R. Then, Ontology Kyoto Encyclopaedia...
Endometrial carcinoma (EC) is a common malignant neoplasm of the female reproductive tract. The degree type II EC much greater than that I EC, usually presenting with high recurrence rate and poor prognosis. Therefore, present study aimed to examine principal genes associated differentiation in reveal their potential mechanisms. Differentially expressed (DEGs) were selected from gene expression profiles derived Cancer Genome Atlas. Gene Ontology Kyoto Encyclopedia Genes Genomes (KEGG)...
Endometrial carcinoma (EC) is one of the most common gynecological malignant tumors, but its underlying pathogenic mechanisms are largely obscure. Interleukin-22 (IL-22), cytokine in tumor immune microenvironment, was reported to be associated with progression. Here, we aimed investigate regulation IL-22 endometrial carcinoma. Enzyme-linked immunosorbent assay (ELISA) analysis done 27 controls and 51 patients EC. We examined proliferative potential, cycle progression, signaling pathways...
<b><i>Background:</i></b> Our purpose was to evaluate the predictive value of lung immune prognostic index (LIPI) in patients with advanced non-small cell cancer (NSCLC) receiving different treatments. <b><i>Methods:</i></b> A systemic literature search major databases medicine performed explore association LIPI therapeutic effects NSCLC, overall survival (OS) as surrogate marker. As such, HR and 95% CI were simultaneously selected such an...
Objective: This study aimed to investigate the maternal−neonatal outcomes of twin pregnancies mothers with preeclampsia and their association assisted reproductive technology (ART). Methods: A retrospective on clinical outcome data 698 women who delivered in our hospital from December 2013 September 2021 was conducted. Continuous variables were analyzed using a Student’s t-test or Wilcoxon rank-sum test. Categorical Chi-square The risk factors by logistic regression. Results: rate pregnancy...
Endometrial carcinoma (EC) is one of the most common gynecological malignancies. The malignant degree increases between grade (G)1 and G3, EC G3 usually presents a high recurrence rate poor prognosis. Therefore, present study aimed to examine principal genes associated with differentiation in EC. microarrays GSE17025, GSE24537 GSE35784, representing data Type I samples G1 were downloaded from Gene Expression Omnibus. differentially expressed (DEGs) micro (mi)RNAs (DEMs) identified, followed...
As the most common gynecologic malignancy worldwide, cervical cancer (CC) is a serious hazard to health. Therefore, present study aimed identify key genes in CC progression using integrated bioinformatics analysis and experimental validation. The mRNA microarray GSE63514 microRNA (miRNA) GSE86100 were obtained from Gene Expression Omnibus database, differentially expressed (DEGs) miRNAs (DEMs) of identified. Thereafter, GO KEGG functional enrichment analysis, protein‑protein interaction...
Group B Streptococcus (GBS) is a leading infectious cause of adverse pregnancy outcomes such as preterm birth. GBS colonizes the vagina during and can ascend into uterus then infect fetus. It encodes series virulence factors adhesion invasion factors, hemolytic pigments hyaluronidase, which are important to vaginal colonization immune evasion. Immune responses release multiple inflammatory mediators, premature rupture membranes, birth fetal injury. This paper reviews pathogenesis ascending...