Combination therapy with inhibitors of cytotoxic T lymphocyte-associated protein (CTLA)4 and programmed death (PD)-1 has demonstrated efficacy in cancer patients. However, there is little information on CTLA4 PD-1 expression levels their clinical significance across diverse cancers. In this study, we addressed question by analyzing 33 different types along prognostic using The Cancer Genome Atlas (TCGA) Cell Line Encyclopedia datasets. Liver hepatocellular carcinoma (LIHC) patients receiving...

Obstructive sleep apnea syndrome (OSAS) is known to be a risk factor for atherosclerosis (AS), derived from series of chronic inflammatory reactions caused by hypoxia. However, the association between inflammation and high blood pressure hypoxia remains fully elucidated. The aim present study was investigate effect continuous positive airway (CPAP) therapy on cytokines AS. A total 100 patients with OSAS 50 healthy control subjects were enrolled. Fresh venous samples collected prior following...

This study was designed to assess ferroptosis regulator gene (FRG) expression patterns in patients with TNBC based on data derived from The Cancer Genome Atlas (TCGA). Further, it utilized establish a FRG signature, after which the association between this signature and tumor immune microenvironment (TIME) composition assessed, relevant prognostic factors were explored.The TCGA database used obtain RNA datasets clinical information about 190 patients, TNBC-related established using least...

Obstructive sleep apnea (OSA) is one of the leading respiratory disorders, increasing risk cardiometabolic diseases. In study, we investigated association between OSA and diseases all-cause cardiovascular mortality in adults.Participants were enrolled National Health Nutrition Examination Survey. The baseline covariates compared participants with without status. Multivariable logistic regression was performed to explore diseases, while Cox proportional for mortality.OSA status positively...

Metal artifacts in computed tomography (CT) images can significantly degrade image quality and impede accurate diagnosis. Supervised metal artifact reduction (MAR) methods, trained using simulated datasets, often struggle to perform well on real clinical CT due a substantial domain gap. Although state-of-the-art semi-supervised methods use pseudo ground-truths generated by prior network mitigate this issue, their reliance fixed limits both the quantity of these ground-truths, introducing...

Metal artifacts in computed tomography (CT) images can significantly degrade image quality and impede accurate diagnosis. Supervised metal artifact reduction (MAR) methods, trained using simulated datasets, often struggle to perform well on real clinical CT due a substantial domain gap. Although state-of-the-art semi-supervised methods use pseudo ground-truths generated by prior network mitigate this issue, their reliance fixed limits both the quantity of these ground-truths, introducing...

Objectives Oral and maxillofacial diseases affect approximately 3.5 billion people worldwide. With the continuous advancement of Artificial Intelligence technologies, particularly application generative pre-trained transformers like ChatGPT-4, there is potential to enhance public awareness prevention early detection these diseases. This study evaluated performance ChatGPT-4 in addressing oral disease questions using standard approaches Chain Thought (CoT) method, aiming gain a deeper...

Background Previous studies have documented a high incidence of toxicity in patients with ultra‐central non‐small cell lung cancer (UC‐NSCLC) treated stereotactic body radiation therapy (SBRT). However, these mainly focused on early stage and included small sample populations. We reviewed the outcomes SBRT advanced UC‐NSCLC at our institution. Methods Fifty‐one consecutive using regular regimen 35 Gy administered five fractions between December 2014 August 2017 were reviewed. UC was defined...

Abstract Atherosclerotic plaque instability contributes to ischaemic stroke and myocardial infarction. This study is compare the abundance difference of immune cell subtypes within unstable atherosclerotic tissues. CIBERSORT was used speculate proportions 22 types based on a microarray carotid artery samples. R software utilized illustrate bar plot, heat map vioplot. The landscape in atherosclerosis diverse, dominated by M2 macrophages, M0 resting CD4 memory T cells CD8 cells. There...

Abstract Background Colon cancer is one of the leading causes deaths in USA and around world. Molecular level characters, such as gene expression levels mutations, may provide profound information for precision treatment apart from pathological indicators. Transcription factors function critical regulators all aspects cell life, but transcription factors-based biomarkers colon prognosis were still rare necessary. Methods We implemented an innovative process to select variables evaluate...

Metastatic spread of tumor through lymphatic vasculature is an important adverse prognostic factor in a variety human cancer and lymphangiogenesis requires the interplay several growth factors. Platelet-derived (PDGF)-BB vascular endothelial (VEGF)-C are two molecules involving metastasis lymphangiogenesis. Therefore, aim this study was to investigate coexpression PDGF-BB VEGF-C primary non-small cell lung (NSCLC) its association with Using immunohistochemical staining, expression were...

Colorectal Cancer (CRC) is the third leading cause of cancer death among men and women in United States. Research has shown that risk CRC associates with genetic lifestyle factors. It possible to prevent or minimize certain risks by adopting a healthy lifestyle. Existing Clinical Decision Support Systems (CDSS) mainly targeted physicians as CDSS users. As result, availability patient-oriented limited. Our project develop for active management.We implemented an online public learn about CRC,...

Abstract Background Cigarette smoking and PM 2.5 are important risk factors of Chronic Obstructive Pulmonary Disease (COPD). However, the joint association cigarette with COPD is unknown. Methods A community-based study was conducted among urban rural adults aged 40 + years between May December 2015 in Jiangsu Province, China. The outcome variable spirometry-defined COPD. Explanatory measures were status (non-smokers or smokers) exposure [low level (< 75 μg/m 3 ) high (≥ )]. Mixed-effects...

Introduction: Programmed cell death protein 1 (PD-1), an immune checkpoint molecule, has recently been recognized as a predictive and prognostic biomarker in several malignant tumors, but its diagnostic value remains largely unknown. We aimed to investigate the differential efficiency of PD-1 other molecules propose panel combined with cancer antigen 15-3 (CA15-3) distinguish breast (BC) from benign disease (BBD). Patients methods: Ninety-one eligible BC patients 31 BBD were enrolled....

There were many articles about double-barreled fibular flap for mandibular reconstruction. The upper layer bone was suit implant placement as a new alveolar. lower necessary contour. But the accurate relationship between 2 layers rarely reported.The purpose of this study twofold: to evaluate feasibility novel design from virtual surgery actual result; accuracy and results occlusion-guided free in mandible reconstruction.From 2010 2016, 52 patients underwent segmental reconstruction with...

Abstract Background: Chronic obstructive pulmonary disease (COPD) is a common public health problem worldwide. Recent studies have reported that socioeconomic status (SES) related to the incidence of COPD. This study aimed investigate association between SES and COPD among adults in Jiangsu province, China, determine possible direct indirect effects on morbidity Methods: A cross-sectional was conducted aged 40 years above May December 2015 China. Participants were selected using multistage...

Low vitamin D status has been linked to an increased risk for various inflammatory diseases. Conflicting results have reported regarding chronic obstructive pulmonary disease (COPD). This study aims investigate the associations of serum 25-hydroxyvitamin (25(OH)D) concentrations with COPD and survival.We included 403 648 participants 25(OH)D measurements free at baseline from UK Biobank. Follow-up was until 30 September 2021. Multivariable-adjusted cox regression models were applied estimate...

Abstract Background No report focused on the life quality of Chinese patients with chronic urticaria (CU). It was also due to lack data assess usage Dermatology Life Quality Index (DLQI) in patients. Objectives We explored (QoL) CU and assessed factor structure reliability version DLQI. Methods The DLQI scores were recorded evaluate out‐patients CU. using analysis analysis. Results A total 131 completed mean score 9.93 that significantly associated patient’s age ( P = 0.01). Chronic had...

This single-center, observational study analyzed the association between plasma concentration of sorafenib and its safety efficacy in Chinese patients with metastatic renal cell carcinoma (mRCC). Adult RCC (n = 94), treated were enrolled January 2014 2015. Sorafenib concentrations measured by liquid chromatography-tandem mass spectrometry. Safety variables evaluated using National Cancer Institute-Common Toxicity Criteria for Adverse Events Response Evaluation Solid Tumors criteria....