A5003705537- Algorithms and Data Compression
- Data Management and Algorithms
- Advanced SAR Imaging Techniques
- Network Packet Processing and Optimization
- Malaria Research and Control
- Advanced Database Systems and Queries
- Soil Carbon and Nitrogen Dynamics
- Computational Drug Discovery Methods
- RNA and protein synthesis mechanisms
- Protein Structure and Dynamics
- Machine Learning in Bioinformatics
- Synthetic Aperture Radar (SAR) Applications and Techniques
- Radar Systems and Signal Processing
- Mosquito-borne diseases and control
- Data Mining Algorithms and Applications
- Invertebrate Immune Response Mechanisms
- Underwater Acoustics Research
- HVDC Systems and Fault Protection
- Internet Traffic Analysis and Secure E-voting
- Peatlands and Wetlands Ecology
- Atmospheric and Environmental Gas Dynamics
- High-Voltage Power Transmission Systems
- Histone Deacetylase Inhibitors Research
- Iron Metabolism and Disorders
- Infrared Target Detection Methodologies
Chinese Academy of Sciences
2019-2025
University of Chinese Academy of Sciences
2018-2025
Institute of Semiconductors
2024-2025
Aerospace Information Research Institute
2022-2024
Shenyang University of Technology
2024
Northwest A&F University
2023
Universidad de Londres
2023
Institut Pasteur of Shanghai
2018-2023
Shanghai University
2018-2023
Soochow University
2021-2023
Genetic manipulation remains a major obstacle for understanding the functional genomics of deadliest malaria parasite Plasmodium falciparum . Although CRISPR/Cas9 (clustered regularly interspaced short palindromic repeat/CRISPR-associated protein 9) system has been successfully applied to introduce permanent changes in genome, its use is still limited. Here we show that fusing different epigenetic effector domains Cas9 null mutant efficiently and specifically reprograms expression target...
Abstract Although artemisinin combination therapies have succeeded in reducing the global burden of malaria, multidrug resistance deadliest malaria parasite, Plasmodium falciparum , is emerging worldwide. Innovative antimalarial drugs that kill all life-cycle stages parasites are urgently needed. Here, we report discovery compound JX21108 with broad antiplasmodial activity against multiple parasites. was developed from chemical optimization quisinostat, a histone deacetylase inhibitor. We...
Abstract Resistance to small-molecule drugs is the main cause of failure therapeutic in clinical practice. Missense mutations altering binding ligands proteins are one critical mechanisms that result genetic disease and drug resistance. Computational methods have made a lot progress for predicting affinity changes identifying resistance mutations, but their prediction accuracy speed still not satisfied need be further improved. To address these issues, we introduce structure-based machine...
Insight into how mutations affect protein stability is crucial for engineering, understanding genetic diseases, and exploring evolution. Numerous computational methods have been developed to predict the impact of amino acid substitutions on stability. Nevertheless, comparing these poses challenges due variations in their training data. Moreover, it observed that they tend perform better at predicting destabilizing than stabilizing ones. Here, we meticulously compiled a new dataset from three...
On-satellite information processing enables all-weather target tracking. The background of videos from satellite sensors exhibits an affine transformation due to their motion relative the Earth. In complex moving backgrounds, vehicles have a small number pixels and weak texture features. At same time, resources performance on-satellite equipment are limited. To address these issues, we propose multi-object tracking (MOT) algorithm with detection–association framework for in backgrounds...
With the growing popularity of Internet applications and widespread use mobile Internet, traffic has maintained rapid growth over past two decades. Traffic Archival Systems (ITAS) for packets or flow records have become more widely used in network monitoring, troubleshooting, user behavior experience analysis. Among three key technologies ITAS, we focus on bitmap index compression algorithm give a detailed survey this paper. The current state-of-the-art encoding schemes include: BBC, WAH,...
Gametocyte is the sole form of Plasmodium falciparum which transmissible to mosquito vector. Here, we report that an Apicomplexan Apetala2 (ApiAP2) family transcription factor, PfAP2-G2 (Pf3D7_1408200), plays a role in development gametocytes P. by regulating expression PfMDV-1 (Pf3D7_1216500) . Reverse transcriptase-quantitative PCR (RT-qPCR) analysis showed was highly expressed ring stage. Indirect immunofluorescence assay nuclear localization asexual stages. The knockout led ~95% decrease...
Archiving of Internet traffic is essential for analyzing network events in the field security. Currently, bitmap indexing used to accelerate and search queries archival data. However, generation index needs large storage space, which makes compression a must-have function. In this paper, we propose new encoding algorithm named SECOMPAX (Scope-Extended COMPressed Adaptive indeX), performs better ratio fast speed compared with state-of-art WAH (Word-Aligned-Hybrid), PLWAH(Position list word...
The application of machine learning techniques in biological research, especially when dealing with limited data availability, poses significant challenges. In this study, we leveraged advancements method development for predicting protein-protein binding strength to conduct a systematic investigation into the on data. strength, quantitatively measured as affinity, is vital understanding processes recognition, association, and dysfunction that occur within protein complexes. By incorporating...
We present a system for summarization and interactive exploration of high-valued aggregate query answers to make large set possible more informative the user. Our outputs clusters on showing their common properties such that are diverse as much avoid repeating information, cover certain number top original indicated by Further, facilitates helping user (i) choose combinations parameters clustering, (ii) inspect well elements they contain, (iii) visualize how changes in affect clustering....
We present a system for summarization and interactive exploration of high-valued aggregate query answers to make large set possible more informative the user. Our outputs clusters on showing their common properties such that are diverse as much avoid repeating information, cover certain number top original indicated by Further, facilitates helping user (i) choose combinations parameters clustering, (ii) inspect well elements they contain, (iii) visualize how changes in affect clustering....
Bitmap index is widely used in archiving and searching of Internet traffic, which an essential step for analyzing network events the field forensics. However, bitmap requires a large storage space fast archival data. As current state-of-the-art compression techniques, various encoding algorithms have been proposed, e.g. WAH, PLWAH, COMPAX, etc. With advantages query speed easy implementation, PLWAH outstanding scheme to encode sparse dirty bits index. Unfortunately, constructed can be quite...
Archiving of the Internet traffic is essential for analyzing network events in field security and forensics. The bitmap index widely used to achieve fast searching archival data requiring a large storage space. As current state-of-art, WAH, PLWAH COMPAX are proposed compressing indexes. In this paper, new compression scheme, named PLWAH+ (Position List Word Aligned Hybrid Plus), introduced, based on PLWAH. With less consumption, more suitable indexing large-scale high-speed traffic.
Space–time waveform-encoding (STWE) SAR can receive echoes from multiple sub-swaths simultaneously with a single window. The overlap each other in the time domain. To separate different directions, traditional schemes adapt single-null steering techniques for digital beam patterns. However, problems of spaceborne DBF-SAR, practice, such as null extension loss, terrain undulation, elevation angle arrival extension, and antenna control, make conventional scheme unable to effectively...
The three-dimensional (3D) genome structure of human malaria parasite Plasmodium falciparum is highly organized and plays important roles in regulating coordinated expression patterns specific genes such as virulence which are involved antigenic variation immune escape. However, the molecular mechanisms that control 3D remain elusive. Here, by analyzing organization P. falciparum, we identify high-interacting regions (HIRs) with strong chromatin interactions at telomeres loci. Specifically,...
Nitrogen (N) deposition in the context of human activities continuously affects carbon cycle ecosystems. The effect N on soil organic is related to differential responses different fractions. To investigate changes fraction and its influencing factors short-term deposition, four addition gradients:0 (CK), 1.5 (N1), 3 (N2), 6 (N3) g·(m2·a)-1 were set up acacia plantations based field experiments, physicochemical properties, microbial biomass, enzyme measured June September. results showed...
High-resolution wide swath (HRWS) imaging has become a research hotspot in the field of synthetic aperture radars (SARs) recent years. Digital beamforming (DBF) denotes powerful technique for obtaining HRWS images. The DBF can be implemented spaceborne SAR real time but at cost massive digital resources. To solve this problem, an intermediate frequency (IF) real-time processing architecture been proposed, it never validated practice. In letter, X-band 16-channel DBF-SAR and C-band...
Methods for summarizing and diversifying query results have drawn significant attention recently, because they help present with lots of tuples to users in more informative ways. We QAGView (Quick AGgregate View), which provides a holistic overview high-valued aggregate answers the user form summaries (showing high-level properties that emerge from subsets answers) coverage guarantee (for user-specified number top-valued is both diverse (avoiding overlapping or similar summaries) relevant...
Bitmap indexing has been widely used in various applications due to its speed bitwise operations. However, it can consume large amounts of memory. To solve this problem, bitmap coding algorithms have proposed. In paper, we present COMbining Binary And Ternary encoding (COMBAT), a new index algorithm. Typical derived from Word Aligned Hybrid (WAH) are COMPressed Adaptive indeX (COMPAX) and Compressed "n" Composable Integer Set (CONCISE), which combine either two or three continuous words...
The tight gene expression regulation controls the development and pathogenesis of human malaria parasite Plasmodium falciparum throughout complex life cycle. Recent studies have revealed pervasive nascent transcripts in genome P. falciparum, suggesting existence a hidden transcriptome involved dynamic expression. However, landscape related biological functions non-coding RNAs (ns-ncRNAs) are still poorly explored. Here we profiled transcription dynamics by rRNA-depleted stranded RNA...
Bitmap indexing is flexible to conduct boolean operations in data retrieval. Besides, the query processing based on bitmap also very fast. Therefore it has been widely used various big analytics platforms, such as Druid and Spark etc. However, index can consume a large amount of memory, which leads invention different kinds compression algorithms without sacrificing temporal performance. In practice, we are often discommoded by choosing proper algorithm when handling specific problems. after...