A5100344658- dental development and anomalies
- Bone and Dental Protein Studies
- Bone Metabolism and Diseases
- Cancer-related gene regulation
- Oral and Maxillofacial Pathology
- Gene expression and cancer classification
- Oral microbiology and periodontitis research
- Bioinformatics and Genomic Networks
- Salivary Gland Disorders and Functions
- Cleft Lip and Palate Research
- NF-κB Signaling Pathways
- Periodontal Regeneration and Treatments
- Extracellular vesicles in disease
- Endoplasmic Reticulum Stress and Disease
- Bone health and treatments
- MicroRNA in disease regulation
- Biochemical and Molecular Research
- Congenital heart defects research
- Wnt/β-catenin signaling in development and cancer
- Corneal Surgery and Treatments
- TGF-β signaling in diseases
- Immune Cell Function and Interaction
- Proteoglycans and glycosaminoglycans research
- Glycosylation and Glycoproteins Research
- Fibroblast Growth Factor Research
Kyungpook National University
2015-2024
Ajou University
2021-2023
Yonsei University
2008-2023
Chungbuk National University
2023
Institute for Medical Research
2023
Pusan National University
2022
Bucheon University
2022
Soonchunhyang University
2022
National Institute of Agricultural Science and Technology
2022
Chungnam National University
2020-2021
The human tooth is the hardest organ of body, and composed enamel, dentin, dental pulp. Dentin provides basis shape by lining inner parts root crown. Odontoblasts deposit an organic matrix that contains collagen, noncollagenous proteins, phospholipids, growth factors. In this study, we sought to reveal proteins in dentin using liquid chromatography−tandem mass spectroscopy (LC-MS/MS) proteomic approaches. Human third molar dentins were cut, isolated, demineralized, extracted separated on...
While the soluble proteins of human teeth consist various extracellular matrix and bioactive proteins, they have not yet been characterized fully. Moreover, role play in tooth regeneration is clear. Analysis by liquid chromatography-mass spectrometry revealed 147 different ethylenediaminetetraacetic acid-soluble (ESTPs). Of these, 29 had shown previously to be present teeth. To determine their effect on vitro responses dental pulp stem cells (DPSCs), DPSCs were cultured ESTP-coated culture...
Periodontitis is the most common chronic inflammatory disease caused by complex interaction between microbial biofilm and host immune responses. In present study, high-throughput RNA sequencing was utilized to systemically precisely identify gene expression profiles alternative splicing. The pooled RNAs of 10 gingival tissues from both healthy periodontitis patients were analyzed deep followed computational annotation quantification mRNA structures. differential analysis designated 400...
We aimed to compare the physicochemical properties and in vivo efficacy of commercially available nanoemulsion cyclosporine A (CsA) eyedrops benzalkonium chloride (BAC)-induced dry eye disease (DED).Particle size analysis was performed on conventional 0.05% CsA (Restasis, C-CsA) two new types based a self-nanoemulsifying drug delivery system (SNEDDS, SNEDDS-N -T). Turbidometry, pH measurements instability indices each solution were measured. DED induced with BAC, animals treated vehicle or...
Populus trichocarpa has been studied as a model poplar species through biomolecular approaches and was the first tree to be genome sequenced. In this study, we employed high throughput RNA-sequencing (RNA-seq) mediated leaf transcriptome analysis investigate response of four different davidiana cultivars drought stress. Following RNA-seq, compared profiles identified two differentially expressed genes (DEGs) with contrasting expression patterns in drought-sensitive tolerant groups, i.e.,...
To increase the pharmacological effects of red ginseng (RG, steamed root Panax Meyer), RG products modified by heat process or fermentation have been developed. However, antiallergic and modified/fermented not simultaneously examined. Therefore, we examined allergic rhinitis (AR)-inhibitory water-extracted (wRG), 50% ethanol-extracted (eRG), bifidobacteria-fermented eRG (fRG) in vivo.RBL-2H3 cells were stimulated with phorbol 12-myristate-13-acetate/A23187. Mice AR prepared treatment...
Abstract Background Periodontitis is an inflammatory disease of the tissues surrounding teeth that causes destruction connective tissues. During progress periodontitis, osteoclasts are solely accountable for resorption alveolar bones leads to loss if not properly treated. Thus, development effective anti‐resorptive therapies will greatly benefit treatment periodontitis patients. In present study, we suggest inhibitory effect 6‐shogaol, ingredient ginger, on osteoclast differentiation and...
Abstract Objective To evaluate the effect of resveratrol on periodontal bone regeneration after local delivery and to determine its inflammatory mediators. Background Resveratrol is considered an anti‐inflammatory polyphenolic stilbene involved in modulation inflammation. Materials Methods Periodontitis was induced mouse molars using a 5‐day ligature model followed by left second molar extraction 50 µM treatment for 1 2 weeks. We then examined specimens treated week histologically with...
Abstract The aim of study was to investigate proliferation and differentiation capacities Hanwoo myosatellite cells for the development cell cultures. From P1 P19, number live decreased size increased. It confirmed that PAX7 mRNA higher in P3 than P6 P9 ( p < 0.05). maximum score measured from P12. maintained high P10. Immunostaining performed both P10 characteristics. And there were no significant differences characteristics between cells. MYOG low, whereas C-FOS 0.05) late passage....
A simple and universal platform for competitive phase-separation immunoassay is reported based on a fusion protein composed of temperature-responsive elastin-like polypeptide (ELP) the antibody-binding staphylococcal (SpA). The basic principle to take advantage ability SpA bind variety antibodies with high affinity, allowing separation antigen−antibody complex by thermal precipitation. resulting ELP−SpA was shown preserve reversibly precipitate as well its affinity toward different IgGs...
A variety of products have been developed with red ginseng (RG, the steamed roots Panax Meyer). To clarify immunomodulating effects water-extracted RG (wRG), 50% ethanol-extracted (eRG), enzyme-treated eRG (ERG) and probiotic-fermented (FRG), we examined their immunopotentiating immunosuppressive in mice cyclophosphamide (CP)-induced immunosuppression (CI) or 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis (TC). Oral administration CI significantly increased blood IFN-[Formula: see...
Abstract The gasdermins are a family of pore-forming proteins that has recently been suggested to play central role in pyroptosis. In this study, we describe the novel roles biogenesis apoptotic cell–derived exosomes. human HeLa and HEK293 cells, GSDMA, GSDMC, GSDMD, GSDME increased release GSDMB DFNB59, contrast, negatively affected at its full-length cleaved forms was localized exosomes exosomal membrane. Full-length increase Ca2+ influx cytosol through endosomal pores thus addition,...
Abstract In this article the unique capability of elastin‐like protein (ELP) to reversibly precipitate was combined with high affinity and specificity antibody‐binding domains such as Protein G, L, or LG a general method for antibody purification that combines in manner simplicity robustness temperature‐triggered precipitation selectivity interactions. single step, antibodies derived from different sources (animal sera hybridoma cell cultures) were selectively recovered by simple temperature...
Ceramides are the major sphingolipid metabolites involved in cell survival and apoptosis. When HepG2 hepatoma cells were treated with celecoxib, expression of genes de novo biosynthesis sphingomyelinase pathway was upregulated cellular ceramide elevated. In addition, celecoxib induced endoplasmic reticulum (ER) stress a time-dependent manner. SPTLC2, subunit serine palmitoyltransferase, overexpressed by adenovirus. Adenoviral overexpression SPTLC2 (AdSPTLC2) decreased viability HEK293 cells....
Abstract Background and Objective After tooth extraction, the extraction socket undergoes several steps of soft hard tissue healing. The healing process is modulated by a range signaling factors biochemical agents. It has been reported that resveratrol, polyphenolic compound, exhibits various biological effects, including anti‐inflammatory, anti‐carcinogenic, antioxidant, anti‐aging protects cardiovascular bone tissues. In this study, we examined cellular effects resveratrol on human...