A5102746212- Rheumatoid Arthritis Research and Therapies
- Spondyloarthritis Studies and Treatments
- Bone and Joint Diseases
- Pregnancy and Medication Impact
- Systemic Lupus Erythematosus Research
- Pregnancy-related medical research
- Vasculitis and related conditions
- Autoimmune and Inflammatory Disorders Research
- Synthesis and Characterization of Pyrroles
- Peripheral Artery Disease Management
- Salivary Gland Tumors Diagnosis and Treatment
- Oxidative Organic Chemistry Reactions
- Chronic Lymphocytic Leukemia Research
- Synthesis and Biological Evaluation
- Synthetic Organic Chemistry Methods
- Synthesis and biological activity
- Coordination Chemistry and Organometallics
- Statistical Methods in Clinical Trials
- Salivary Gland Disorders and Functions
- Catalytic C–H Functionalization Methods
- Asymmetric Synthesis and Catalysis
- Psoriasis: Treatment and Pathogenesis
- Synthesis and pharmacology of benzodiazepine derivatives
- Osteomyelitis and Bone Disorders Research
- Catalytic Alkyne Reactions
Kyung Hee University Hospital at Gangdong
2021-2025
Kyung Hee University
2024
Konkuk University Medical Center
2019-2023
Konkuk University
2023
Gangdong University
2021
ORCID
2021
Soonchunhyang University Hospital
2021
Soonchunhyang University
2021
Chonnam National University
2008-2015
University of North Carolina at Chapel Hill
2008-2009
OBJECTIVES: This study investigated whether Janus kinase inhibitors (JAKis) raise the risk of cardiovascular disease (CVD), venous thromboembolism (VTE), and cancer in patients with rheumatoid arthritis (RA).METHODS: We conducted a real-world retrospective observational using data obtained from Korean National Health Insurance Service database. Two sets were analyzed: tumor necrosis factor inhibitor (TNFi)/JAKi-naive RA (set 1) all who used TNFis or JAKis 2). The incidence rate ratios (IRRs)...
Background/Objectives: Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) significantly affects prognosis and patient survival. The impact of conventional synthetic DMARDs (csDMARDs) biologic/targeted (b/tsDMARDs) on RA-ILD prognoses remains unclear. This study aimed to investigate the effects csDMARDs b/tsDMARDs progression based pulmonary function tests (PFTs), high-resolution computed tomography (HRCT), symptom changes. Methods: multicenter, retrospective, observational...
In many phase I trials, the design goal is to find dose associated with a certain target toxicity rate. some can be weighted sum of rates various grades. For others, mean value continuous response. this article, we describe dose-finding that used in any trials described above, where defined as at which monotone function prespecified value. At each step proposed design, normalized difference between current and computed. If close zero, repeated. Otherwise, increased or decreased, depending on...
We aimed to evaluate the preventive role of tyrosine kinase inhibitor dasatinib in an animal model rheumatoid arthritis (RA).DBA/1J mice were injected with bovine type II collagen induce (collagen-induced [CIA]). There four experimental groups mice, namely negative control (non-CIA), vehicle-treated CIA, dasatinib-pretreated and dasatinib-treated CIA. After immunization, progression was clinically scored twice weekly for 5 weeks. Flow cytometry used vitro CD4+ T-cell differentiation ex vivo...
An efficient two‐step synthetic approach of benzo[ a ]carbazoles from 2‐arylindoles has been developed. The first step is propargylation at the 3‐position catalyzed by montmorillonite K‐10 in benzene. second 1,8‐diazabicyclo[5.4.0]undec‐7‐ene (DBU)‐catalyzed sequential propargyl‐allenyl isomerization and concomitant 6π‐electrocyclization process involving two aromatic π‐bonds.
Background: Abnormal new bone formation can occur not only in the vertebral body but also facet, costovertebral, and costotransverse joints radiographic axial spondyloarthritis (r-axSpA) patients. Little is known about association between syndesmophyte progression paravertebral joint ankylosis r-axSpA. Objectives: Costotransverse r-axSpA patients was measured. Furthermore, for 2 years assessed by computed tomography score (CTSS) were evaluated. Design: Single-center, prospective, cohort...
Abstract Chronic shoulder pain is a common complication in breast cancer patients after surgery. surgery was formerly considered as neuropathic pain, however the pathophysiology including structural damages has not been assessed comprehensively. We hypothesized that change could be one of cause and evaluated various ultrasonography findings with chronic pain. Patients who were suffering from on unilateral side for at least 3 months enrolled single tertiary hospital. Demographic clinical data...
Abstract Background Cardiovascular diseases (CVDs) are the leading cause of death in patients with rheumatoid arthritis (RA). Coronary artery calcium (CAC) score quantifies severity atherosclerosis. We estimated CVD risk using several methods and compared these CAC to identify most suitable calculator RA patients. Methods recruited patients, 10-year was assessed various tools, viz. Framingham score, Systemic Risk Evaluation (SCORE), Atherosclerotic Disease (ASCVD) estimator plus, QRISK3,...
Abstract Herein, we investigated the effect of DJ-1 on helper T cell differentiation, fibroblast-like synoviocyte (FLS) activation, and osteoclastogenesis in rheumatoid arthritis (RA). Serum synovial fluid (SF) RA osteoarthritis (OA) patients were collected, H 2 O levels investigated. CD4 + cells from peripheral blood mononuclear (PBMCs) cultured under type 17 (Th17) polarization conditions, pro-inflammatory cytokine levels, soluble receptor activator nuclear factor kappa-Β ligand (RANKL)...
The reaction of 1,3,5-triketones and arylhydrazines provided indolylpyrazole derivatives in a one-pot good to moderate yields. Both the pyrazole indole rings were constructed simultaneously with phenylhydrazine, <TEX>$RCOCH_2CO$</TEX>- moiety for remaining -<TEX>$CH_2COR$</TEX> part ring.
The clinical data on the biologic disease-modifying antirheumatic drug (bDMARD) use in late-onset ankylosing spondylitis (LOAS) is limited. Thus, this study aimed to evaluate efficacy and retention rate of bDMARDs LOAS compare it young-onset (YOAS). Data patients with AS receiving were extracted from Korean College Rheumatology Biologics Targeted Therapy registry. Patients whose age onset was > 50 years ≤ classified as having YOAS, respectively. Their baseline characteristics...
Abstract The CT syndesmophyte score (CTSS) can evaluate spinal progression more precisely than mSASSS in ankylosing spondylitis (AS); however, it is complex and time consuming. Here, we propose a simplified CTSS (sCTSS) for measuring structural changes AS. Patients with AS were recruited from single tertiary hospital. Baseline 2-year follow-up whole spine images used to calculate sCTSS. sCTSS the anterior posterior vertebral corners, ranged 0–184. Intraclass correlation coefficients (ICC)...
Interstitial lung disease (ILD) is a critical extra-articular manifestation of rheumatoid arthritis (RA). However, little known about the risk factors RA-ILD.
Abstract Rheumatoid arthritis (RA) is a systemic inflammatory in which primary prevention key. However, the impact of lifestyle and comorbidities on RA development unknown. Data from Korean National Health Insurance Service (NHIS)-national sample cohort 2002 to 2016 were used. At baseline, demographic characteristics, socioeconomic status, type residential area, behaviours (including exercise), Charlson Comorbidity Index, CCI) included. Cox regression analysis Kaplan–Meier curves used...
Abstract The present study evaluated the predictive role of baseline radiographic change and disease activity on drug retention clinical response in patients with rheumatoid arthritis (RA) treated tumor necrosis factor inhibitor (TNFi). Korean Observational Study Network for Arthritis (KORONA) registry was to identify RA a TNFi. Disease score-28 (DAS28) at 1 year after TNFi initiation or termination due inefficacy (within year). rate compared without bony erosions. hazard ratio (HR) by Cox...
To compare findings on salivary gland ultrasonography (SGUS) and scintigraphy (SGS) in patients with primary SS (pSS).The study cohort included newly diagnosed pSS who underwent SGUS SGS at the same time our tertiary care hospital. Baseline demographics, laboratory data, clinical data were collected. An cut-off score ≥14 defined positive was used to classify SGUS+ SGUS- groups. quantified by parotid:submandibular uptake ratio (PU:SU) percentage parotid/submandibular excretion (%PE/%SE). The...
Recently “Well Being” trend which regards health as important carries over into the food industry, and is becoming not just a way of satisfying one’s natural urge but spending pattern one"s health, function, culture. This kind phenomenon also shown at beverage market. Most consumers are oriented towards high quality consumption that satisfies only taste function beverage. Therefore, lots new brands born around tea beverage, advertisements lead consumer in rapidly increased.<BR> Today"s have...