A5058302800- Nerve injury and regeneration
- Adipose Tissue and Metabolism
- Neurogenesis and neuroplasticity mechanisms
- Neuropeptides and Animal Physiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Eicosanoids and Hypertension Pharmacology
- Alcohol Consumption and Health Effects
- Liver Disease and Transplantation
- RNA Research and Splicing
- Liver Disease Diagnosis and Treatment
- Sulfur Compounds in Biology
- Receptor Mechanisms and Signaling
- Inflammatory mediators and NSAID effects
- Genomics, phytochemicals, and oxidative stress
- Endoplasmic Reticulum Stress and Disease
- Parkinson's Disease Mechanisms and Treatments
- Ion Channels and Receptors
- Adenosine and Purinergic Signaling
- Amyotrophic Lateral Sclerosis Research
- Hereditary Neurological Disorders
- Neurosurgical Procedures and Complications
- Nutrition and Health in Aging
- Pain Management and Treatment
- Spectroscopy Techniques in Biomedical and Chemical Research
- Calcium signaling and nucleotide metabolism
Kosin University
2012-2025
University of Ulsan
2015
Asan Medical Center
2015
Ulsan College
2015
Ulsan University Hospital
2015
Fascaplysin is a bioactive compound derived from marine sponges, which have anticancer properties and potential neuroprotective effects mediated by mitigation of oxidative stress-induced neurotoxicity. This study investigated the concentration-dependent fascaplysin in zebrafish models, focusing on embryonic survival, cardiac function, melanocyte formation, peripheral nerve health. Zebrafish embryos were exposed to at concentrations ranging 10 nM 100 μM, developmental parameters assessed. At...
Alcohol-associated liver disease (ALD) encompasses a range of hepatic abnormalities, including isolated alcoholic steatosis, steatohepatitis, and cirrhosis. The flavanone-7-O-glycoside narirutin (NRT), the primary flavonoid in citrus peel, has antioxidant, anti-inflammatory, lipid-lowering activity. We investigated effects NRT on injury induced by alcohol explored underlying mechanisms.Zebrafish larvae were used to investigate acute exposure ethanol (EtOH). Liver phenotypic, morphological,...
During Wallerian degeneration, Schwann cells lose their characteristic of myelinating axons and shift into the state developmental promyelinating cells. This recharacterized cell guides newly regrowing to destination remyelinates reinnervated axons. dynamics during degeneration is associated with oxidative events. Heme oxygenases (HOs) are involved in degradation heme biliverdin/bilirubin, ferrous iron, carbon monoxide. Overproduction iron by HOs increases reactive oxygen species, which have...
Several studies have demonstrated that inhibitors of cyclooxygenase (COX) attenuate various neuronal injuries and age-dependent demented conditions. From these findings, we proposed to test the effect age on COX activity its possible suppression by antiaging action dietary restriction in rat brain. The status reactive oxygen species (ROS) was also assessed correlate with delineate underlying mechanism altered during aging. These results showed significantly increased 24-month-old rats...
Cyclooxygenase (COX) is the key rate-limiting enzyme in prostaglandin synthetic pathway. Two isoforms of COX have been identified: a constitutive COX-1 and an inducible COX-2, which activated response to various stimuli. We investigated changes COX-2 rat heart during aging. measured age-related mRNA protein levels by using reverse-transcription polymerase chain reaction Western blotting, respectively. increased with age, whereas those showed no change. The activity determined E2 production...
Background Sedation by dexmedetomidine, like natural sleep, often causes bradycardia. We explored the nature of heart rate (HR) changes as they occur during sleep versus those occurring dexmedetomidine sedation. Methods The present study included 30 patients who were scheduled to undergo elective surgery with spinal anesthesia. To assess HR and sedation, a pulse oximeter bispectral index (BIS) monitor attached patient in ward operating room. After measuring BIS at baseline, slept once their...
G protein-coupled receptor, family C, group 5 (GPRC5B), a retinoic acid-inducible orphan G-protein-coupled receptor (GPCR), is member of the C metabotropic glutamate proteins presumably related in non-canonical Wnt signaling. In this study, we investigated altered GPRC5B expression dorsal horn spinal cord after nerve injury and its involvement development neuropathic pain.After induction anesthesia by intraperitoneal injection pentobarbital (35 mg /kg), left L5 at level 2 mm distal to DRG...
N-ethylmaleimide (NEM) inhibits peripheral nerve degeneration (PND) by targeting Schwann cells in a hydrogen sulfide (H2S)-pathway-dependent manner, but the underlying molecular and pharmacological mechanisms are unclear. We investigated effect of NEM, an α,β-unsaturated carboxyl compound, on H2S signaling vitro- ex vivo-dedifferentiated using global proteomics (LC-MS) transcriptomics (whole-genome small RNA-sequencing (RNA-seq)) methods. The multi-omics analyses identified several genes...
Peripheral nerve degeneration (PND) is a preparative process for peripheral regeneration and regulated by Schwann cells, unique glial cell in the nervous system. Dysregulated PND induces irreversible neurodegenerative diseases (e.g., diabetic neuropathy). To develop novel synthetic drugs these diseases, we synthesized set of new cinnamaldehyde (CAH) derivatives evaluated their activities vitro, ex vivo, vivo. The 12 CAH had phenyl or naphthyl groups with different substitution patterns on...
Han Seo, Hyun-Chae Lee, Ki Chul Doosik Kim, Jiwook Donghee Kang, Hyung-Joo Chung, Hee-Jae Cha, Jeongtae and Kyoung Seob Song. Mol. Cells -0001;0:. https://doi.org/10.14348/molcells.2023.0107
Sarcopenia, the aging-related deterioration of skeletal muscle, is a disease that directly associated with quality life. Given trend an increasing aging population worldwide, prevention diseases such as sarcopenia has become ever more important and urgent.To identify potential therapeutic targets for this disease.we used bioinformatics approach combining cDNA microarray analysis protein-protein interaction prediction.We found 673 significant differentially expressed genes (128 upregulated...
Peripheral neurodegenerative diseases induced by irreversible peripheral nerve degeneration (PND), such as diabetic neuropathy, have a high prevalence worldwide and reduce the quality of life. However, there is no agent effective against PND. After injury, Schwann cells play an important role in regulating because PND involves multiple biochemical events cells, one-drug-single-target therapeutic strategy not feasible for Here, we suggested that fascaplysin (Fas), compound with targets...
Liver cirrhosis is a severe chronic disease that results from various etiological factors and leads to substantial morbidity mortality. Alcoholic (AC) non-AC (NAC) arise prolonged excessive consumption of alcohol metabolic syndromes, respectively. Precise molecular mechanisms AC NAC are yet be comprehensively understood for diagnostics therapeutic advances materialize. This study reports novel findings this end by utilizing high-throughput RNA sequencing microarray data the Gene Expression...
Chronic hand pain poses a clinical challenge, especially when standard diagnostic tests return negative results. This case report details 45-year-old woman who experienced persistent stiffness and in both hands for 20 years, which was effectively treated with stellate ganglion block (SGB). The patient, employed an office setting that required extensive computer use, noticed her symptoms worsened during busy work periods. Despite blood rheumatoid factor, anticyclic citrullinated peptide...
Aminoacyl-tRNA synthetase-interacting multifunctional proteins (AIMPs) are auxiliary factors involved in protein synthesis related to aminoacyl-tRNA synthetases (ARSs). AIMPs, which well known as nonenzymatic factors, include AIMP1/p43, AIMP2/p38, and AIMP3/p18. The canonical functions of AIMPs not only via multisynthetase complexes but also maintenance the structural stability these complexes. Several recent studies have demonstrated nontypical (noncanonical) such roles apoptosis,...
Microarray technology has become an indispensable tool for monitoring the levels of gene expression in a given organism through organization, analysis, interpretation, and utilization biological sequences.Importantly, preliminary microarray differs from experimentally validated expression.Generally, analysis microglial cells is used to identify genes brain spinal cord that are responsible onset neurodegenerative diseases; these either upregulated or downregulated.In present study, 770...