A5077727134- Pancreatic and Hepatic Oncology Research
- Clusterin in disease pathology
- Parkinson's Disease Mechanisms and Treatments
- Ferroptosis and cancer prognosis
- Lysosomal Storage Disorders Research
- Mitochondrial Function and Pathology
- Nuclear Receptors and Signaling
- Soybean genetics and cultivation
- Autism Spectrum Disorder Research
- Protease and Inhibitor Mechanisms
- Legume Nitrogen Fixing Symbiosis
- biodegradable polymer synthesis and properties
- Advanced Image and Video Retrieval Techniques
- Signaling Pathways in Disease
- Image Retrieval and Classification Techniques
- Insect behavior and control techniques
- Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Management of metastatic bone disease
- Video Analysis and Summarization
- Insect Resistance and Genetics
- Genetic Neurodegenerative Diseases
- Epilepsy research and treatment
- Sarcoma Diagnosis and Treatment
University of Manchester
2023
Lancashire Teaching Hospitals NHS Foundation Trust
2023
Seoul National University
2017-2022
Korea Research Institute of Bioscience and Biotechnology
2013
Despite the importance of soybean as a major crop, genome-wide variation and evolution cultivated soybeans are largely unknown. Here, we catalogued genome in an annual population by high-depth resequencing 10 6 wild accessions obtained 3.87 million high-quality single-nucleotide polymorphisms (SNPs) after excluding sites with missing data any accession. Nuclear phylogeny supported single origin for soybeans. We identified 10-fold longer linkage disequilibrium (LD) relative to maize rice....
DJ-1 is one of the causative genes for early onset familiar Parkinson's disease (PD) and also considered to influence pathogenesis sporadic PD. has various physiological functions which converge on controlling intracellular reactive oxygen species (ROS) levels. In RNA-sequencing analyses searching novel anti-oxidant downstream DJ-1, a gene encoding NADP+-dependent isocitrate dehydrogenase (IDH), converts into α-ketoglutarate, was detected. Loss IDH induced hyper-sensitivity oxidative stress...
The function of AarF domain-containing kinase 1 (ADCK1) has not been thoroughly revealed. Here we identified that ADCK1 utilizes YME1-like ATPase (YME1L1) to control optic atrophy (OPA1) and inner membrane mitochondrial protein (IMMT) in regulating dynamics cristae structure. We firstly observed a serious developmental impairment occurred Drosophila (dADCK1) deletion mutant, resulting premature death before adulthood. By using temperature sensitive ubiquitously expression driver...
The current study aimed to develop a prediction model using multi-marker panel as diagnostic screening tool for pancreatic ductal adenocarcinoma.Multi-center cohort of 1991 blood samples were collected from January 2011 September 2019, which 609 normal, 145 other cancer (colorectal, thyroid, and breast cancer), 314 benign disease, 923 adenocarcinoma. automated multi-biomarker Enzyme-Linked Immunosorbent Assay kit was developed three potential biomarkers: LRG1, TTR, CA 19-9. Using logistic...
Abstract Although levodopa is the most effective medication for Parkinson’s disease, long-term treatment largely compromised due to late motor complications, including levodopa-induced dyskinesia (LID). However, genetic basis of LID pathogenesis has not been fully understood. Here, we discover genes pathogenic using Drosophila genetics and behavioral analyses combined with genome-wide association studies on 578 patients clinically diagnosed LID. Similar therapeutic effect in patients, acute...
Diagnostic biomarkers of pancreatic ductal adenocarcinoma (PDAC) have been used for early detection to reduce its dismal survival rate. However, clinically feasible are still rare. Therefore, in this study, we developed an automated multi-marker enzyme-linked immunosorbent assay (ELISA) kit using 3 (leucine-rich alpha-2-glycoprotein [LRG1], transthyretin [TTR], and CA 19-9) that were previously discovered proposed a diagnostic model PDAC based on clinical usage.Individual LRG1, TTR, 19-9...
Genetic mechanisms for the pathogenesis of visceral myopathy (VM) have been rarely demonstrated. Here we report role misato (mst) in Drosophila and its implications VM. Depletion mst using three independent RNAi lines expressed by a pan-muscular driver elicited characteristic symptoms VM, such as abnormal dilation intestinal tracts, reduced gut motility, feeding defects, decreased life span. By contrast, exaggerated expression intestine diameters, but increased motilities along with...
Introduction:The current study aimed to develop a prediction model using multi-marker panel as diagnostic screening tool for pancreatic-ductal-adenocarcinoma.Methods: Multi-center cohort of 1,991 blood samples were collected from January 2011 September 2019, which 609 are normal, 145 other-cancer (colorectal, thyroid, and breast cancer), 314 pancreatic-benign-disease, 923 pancreatic-ductal-adenocarcinoma.The automated multi-biomarker Enzyme-Linked Immunosorbent Assay kit was developed three...
Abstract Aim Metastatic Spinal Cord Compression (MSCC) is one of the most important complications cancer. Surgical decompression an treatment for MSCC with proven benefits in overall survival, yet it highly invasive and carries a significant morbidity mortality risk. This study aims to review outcome surgery, including local recurrence, post-operative ambulatory function. Method A retrospective data 121 patients who underwent surgery at Lancashire Teaching Hospitals over 8 years Blackpool...
Abstract Background Early diagnosis is paramount in increasing the survival rate of pancreatic ductal adenocarcinoma (PDAC). However, effective early diagnostic tools are lacking at present. The current study aimed to develop a prediction model using multi-marker panel (LRG1, TTR, and CA19-9) as screening tool for PDAC. Methods A large multi-center cohort 1,991 samples were collected from January 2011 September 2019, which 609 normal (NL), 145 other cancer (OC; colorectal, thyroid, breast...