A5105826909- Reconstructive Facial Surgery Techniques
- Cancer-related gene regulation
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Cancer-related Molecular Pathways
- Reconstructive Surgery and Microvascular Techniques
- Liver Disease Diagnosis and Treatment
- Estrogen and related hormone effects
- Sarcoma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Bioactive Compounds and Antitumor Agents
- Inflammatory mediators and NSAID effects
- Cancer-related molecular mechanisms research
- Chronic Kidney Disease and Diabetes
- TGF-β signaling in diseases
- Renal and related cancers
- Facial Nerve Paralysis Treatment and Research
- Liver physiology and pathology
- PARP inhibition in cancer therapy
- Cardiovascular Health and Disease Prevention
- Genetic and Kidney Cyst Diseases
- Microtubule and mitosis dynamics
- Healthcare cost, quality, practices
- Ginseng Biological Effects and Applications
- Head and Neck Anomalies
Sutter Medical Center
2024
Yonsei University
2018-2023
Yonsei University College of Dentistry
2018-2023
Seoul National University
2000-2021
Chosun University
2014
Samsung Medical Center
2012-2013
Sungkyunkwan University
2012-2013
Inje University Sanggye Paik Hospital
2007
Recently, a novel intestinal bacterial metabolite of ginseng protopanaxadiol saponins, i.e., 20-O-(beta-D-glucopyranosyl)-20(S)-protopanaxadiol (IH-901), has been reported to induce apoptosis in variety cancer cells. Here we show differential effect IH-901 on several cell types. Exposure for 48 hours at supposedly subapoptotic concentration 40 mumol/L led both apoptotic death and G1 arrest Hep3B cells, but only resulted MDA-MB-231, Hs578T, MKN28 Additionally, the treatment not Hep3B, with...
Silencing of p16INK4a by methylation the CpG islands in promoter region has been found to be an alternative mechanism inactivation several tumors. However, gastric carcinoma, relationship between status and transcriptional silencing p16 gene remains clarified. In this study, we investigated whether a few specific sites could significantly down-regulate activity tumorigenesis carcinoma. By Southern analysis bisulfite-modified genomic sequencing 9 gastric-carcinoma cell lines, that 5 lines...
The Wnt and Hippo pathways are tightly coordinated understanding their reciprocal regulation may provide a novel therapeutic strategy for cancer. Anti-helminthic niclosamide is an effective inhibitor of now in phase II trial advanced colorectal cancer (CRC) patients. We found that Axin2, authentic target gene canonical Wnt, acts as aYAP phosphorylation activator APC-mutated CRC. While effectively suppresses it also inhibits Hippo, limiting its potential To overcome this limitation, we...
Background Approximately 30% of diabetic patients develop nephropathy, a representative microvascular complication. Although the etiological mechanism has not yet been fully elucidated, renal tubular damage by hyperglycemia-induced expression transforming growth factor-β (TGF-β) is known to be involved. Recently, new type cell death iron metabolism called ferroptosis was reported involved in kidney animal models which could induced TGF-β. Bone morphogenetic protein-7 (BMP7) well-known...
Tubulointerstitial renal fibrosis is a chronic disease process affecting kidney (CKD). While the etiological role of transforming growth factor-beta (TGF-β) well known for epithelial–mesenchymal transition (EMT) in disease, effective therapeutics are largely limited. As member TGF-β superfamily, bone morphogenetic protein-7 (BMP-7) plays an important as endogenous antagonist TGF-β, inhibiting fibrotic progression many organs. However, soluble rhBMP-7 hardly available due to its limited...
The epithelial-mesenchymal transition (EMT) comprises an important biological mechanism not only for cancer progression but also in the therapeutic resistance of cells. While importance protein abundance EMT-inducers, such as Snail (SNAI1) and Zeb1 (ZEB1), during EMT is clear, reciprocal interactions between untranslated regions (UTRs) EMT-inducers via a competing endogenous RNA (ceRNA) network have received little attention. In this study, we found synchronized transcript mediated by...
Jun Seop Yun, Hyeeun Song, Nam Hee Kim, So Young Cha, Kyu Ho Hwang, Jae Eun Lee, Cheol-Hee Jeong, Sang Hyun Seonghun Eunae Sandra Cho, Sil and Jong In Yook. Mol. Cells 2022;45:911-22. https://doi.org/10.14348/molcells.2022.0130
Abstract Background The prognosis of fulminant hepatic failure ( FHF ) depends on the etiology and reversibility. In this study, we identified etiological difference in Korea analyzed prognostic factors after liver transplantation LT for . Methods We retrospectively reviewed 42 patients with who underwent from A pril 1999 to 2011 at S amsung M edical C enter, eoul, K orea. were categorized into two groups according short‐term result , perioperative profiles compared identify poor factors....
Purpose We wanted to demonstrate the anti-cancer effect and interaction between belotecan cisplatin on gastric cancer cell line we evaluated mechanisms of this synergistic in vitro. Materials Methods The growth inhibitory belotocan against several lines (SNU-5, SNU-16 SNU-601) was estimated by tetrazolium dye assay. a combination treatment isobologram method. biochemical for drugs were analyzed measuring formation DNA interstrand cross-links (ICLs) topo-I activity. Results Belotecan showed...
Dear Editor: Granuloma annulare (GA) is a benign inflammatory skin disease that classically presents as annular, flesh-colored grouped papules. It most commonly develops on the dorsal aspect of hands, although cases palmar involvement are very rare1. We report rare case GA arising right palm 2-year-old healthy boy and review related literature. A Korean aged 2 years came to our clinic with an asymptomatic solitary annular shaped plaque his palm. had started develop about 4 weeks ago...
Abstract Background To enhance the utility of functional hemodynamic monitoring, variables systolic slope (dP/dt) and dynamic arterial elastance (Ea dyn ) are calculated by Hypotension Prediction Index (HPI) Acumen® Software. This study was designed to characterize effects phenylephrine ephedrine on dP/dt Ea . Methods a retrospective, non-randomized analysis data collected during two clinical studies. All patients required intra-operative controlled mechanical ventilation had an indwelling...
ABSTRACT A structural protein of SARS-CoV-2, nucleocapsid (N) is abundantly expressed during viral replication. The N phosphorylated by glycogen synthase kinase (GSK)-3 on the serine/arginine (SR) rich motif located in disordered regions. Although phosphorylation GSK-3β constitutes a critical event for replication, molecular mechanism underlying not well understood. In this study, we found putative alpha-helix L/FxxxL/AxxRL known as GSK-3 interacting domain (GID), commonly many endogenous...
Abstract Background Poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP)is the member of a family enzymes that catalyze addition ADP-ribose units to proteins mediate DNA repair pathways. Olaparib (KU-0059436; AZD2281) is potent oral inhibitor PARP currently in clinical development, which has selective antitumor activity cancers, associated with BRCA1 and BRCA2 mutations. Gastric cancer most common second leading cause deaths Korea. New therapies including molecular targeting agents are...