A5036171145- Cancer, Lipids, and Metabolism
- Immune cells in cancer
- Wnt/β-catenin signaling in development and cancer
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Medical Imaging Techniques and Applications
- Cancer-related gene regulation
- Histone Deacetylase Inhibitors Research
- Amino Acid Enzymes and Metabolism
- PI3K/AKT/mTOR signaling in cancer
- Hippo pathway signaling and YAP/TAZ
- Adenosine and Purinergic Signaling
- Liver Disease Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
Yonsei University
2020-2022
Severance Hospital
2022
Myeloid-derived suppressor cells (MDSCs) and M2 macrophages in the tumor microenvironment contribute to progression by inducing immune tolerance antigens cancer cells. Metformin, one of most common diabetes drugs, has shown anti-inflammatory anti-tumor effects. However, effects metformin on inflammatory its underlying mechanisms remain unclarified. In this study, we investigated effect MDSCs using monocyte THP-1 a dextran sodium sulfate (DSS)-treated ApcMin/+ mouse model colon cancer....
The Wnt and Hippo pathways are tightly coordinated understanding their reciprocal regulation may provide a novel therapeutic strategy for cancer. Anti-helminthic niclosamide is an effective inhibitor of now in phase II trial advanced colorectal cancer (CRC) patients. We found that Axin2, authentic target gene canonical Wnt, acts as aYAP phosphorylation activator APC-mutated CRC. While effectively suppresses it also inhibits Hippo, limiting its potential To overcome this limitation, we...
Abstract Glutamine provides carbon and nitrogen for macromolecular synthesis participates in adenosine triphosphate (ATP) generation, anabolic metabolism, redox homeostasis, cell signaling, cancer stem (CSC) metabolism. New treatment strategies targeting glutamine metabolism have emerged recently. We previously reported the magnetic resonance imaging (MRI) assessment of uptake by tumors activated CSC. In present study, using MRI, we determined correlation between distribution transporters,...
Purpose: Wnt and mammalian target of rapamycin (mTOR) are major molecular signaling pathways associated with the development progression tumor, as well maintenance proliferation cancer stem cells (CSCs), in colorectal (CRC).Identifying patients at risk poor prognosis is important to determining whether add adjuvant treatment stage II CRC thus improve survival.In present study, we evaluated prognostic value Wnt, mTOR, CSC markers survival predictors CRC.Materials Methods: We identified 148...