A5101601120- Neonatal and fetal brain pathology
- Cerebral Palsy and Movement Disorders
- Neurogenesis and neuroplasticity mechanisms
- Infant Development and Preterm Care
- Mesenchymal stem cell research
- Neurogenetic and Muscular Disorders Research
- Retinopathy of Prematurity Studies
- Anesthesia and Neurotoxicity Research
- Meningioma and schwannoma management
- Biochemical effects in animals
- Pharmacological Effects and Toxicity Studies
- Salivary Gland Disorders and Functions
- Spectroscopy Techniques in Biomedical and Chemical Research
- Infectious Diseases and Tuberculosis
- Facial Nerve Paralysis Treatment and Research
- Protein Hydrolysis and Bioactive Peptides
- Ocular Diseases and Behçet’s Syndrome
- Ear Surgery and Otitis Media
- Ear and Head Tumors
- Fatty Acid Research and Health
- Metabolomics and Mass Spectrometry Studies
- Spinal Dysraphism and Malformations
- Neonatal Respiratory Health Research
Chinese PLA General Hospital
2015-2024
Shanghai Jiao Tong University
2016-2020
Shanghai Ninth People's Hospital
2020
PLA Navy General Hospital
2011-2012
Cerebral palsy (CP) is a chronic nervous system disease that severely damages the physical and developmental health of children. Traditional treatment brings about only improvement mild to moderate CP, but severe CP still lacks effective interventions. To explore safety efficacy using neural progenitor cells (NPCs) treat in children, we performed NPC transplantation 45 patients with by injecting NPCs derived from aborted fetal tissue into lateral ventricle. Gross motor function measures...
Stem cell administration via the intranasal route has shown promise as a new therapy for hypoxic-ischemic encephalopathy (HIE). In this study, we aimed to improve delivery of stem cells brain.Human neural (hNSCs) were identified using immunofluorescence, morphological, and flow cytometry assays before transplantation, migration capacity was examined transwell assay. Cerebral hypoxia-ischemia (HI) induced in 7-day-old rats, followed by transplantation CM-Dil-labeled hNSCs. We various...
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Highlights•Intracerebral injection of ET-1 modelled key functional and histopathological features cerebral palsy.•hNSCs transplanted during the sequelae phase resulted in long-term improvement motor performance palsy rats.•The possibly attributed to hNSCs' capacity stimulate neurotrophic factors, facilitate neurogenesis, angiogenesis, promote axonal plasticity.AbstractAimsCerebral (CP) is most common physical disability children, yet lacks an ideal animal model or effective treatment. This...
Background Bell’s palsy (BP) is the most common form of acute facial nerve disorder and characterized by rapid onset peripheral unknown etiology. Purpose To explore diagnostic value dynamic contrast-enhanced (DCE) magnetic resonance imagine (MRI) in patients with BP particularly involved segments. Material Methods A retrospective analysis was performed on who underwent routine MRI examinations volumetric interpolated breath-hold examination (VIBE) sequence-based DCE-MRI before surgery our...
Cerebral white matter injury (WMI) is the most common brain in preterm infants, leading to motor and developmental deficits often accompanied by cognitive impairment. However, there no effective treatment. One promising approach for treating WMI cell replacement therapy, which lost cells can be replaced exogenous oligodendrocyte progenitor (OPCs).This study developed a method differentiate human neural stem (hNSCs) into OPCs (hOPCs). The animal model was established rats on postnatal day 3,...
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