A5101769509- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Hematological disorders and diagnostics
- Autoimmune and Inflammatory Disorders Research
- Multiple Myeloma Research and Treatments
- Advanced Data Compression Techniques
- Immune Cell Function and Interaction
- Sarcoma Diagnosis and Treatment
- Neutropenia and Cancer Infections
- Neurogenetic and Muscular Disorders Research
- Parvovirus B19 Infection Studies
- Blood disorders and treatments
- Mycobacterium research and diagnosis
- Retinoids in leukemia and cellular processes
- Protein Degradation and Inhibitors
- Tuberculosis Research and Epidemiology
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Lymphoma Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Dermatological and COVID-19 studies
- Advanced Image and Video Retrieval Techniques
- AI and Big Data Applications
Westlake University
2024
Zhengzhou University
2024
China Southern Power Grid (China)
2018-2023
Peking University
2007-2023
Chinese PLA General Hospital
2023
Guiyang Medical University
2023
Peking University People's Hospital
2007-2023
Beihang University
2023
Capital Normal University
2019-2023
Sichuan University
2022
Abstract Acute myeloid leukemia (AML) with retinoic acid receptor γ (RARG) rearrangement has clinical, morphologic, and immunophenotypic features similar to classic acute promyelocytic leukemia. However, AML RARG is insensitive alltrans (ATRA) arsenic trioxide (ATO) carries a poor prognosis. We initiated global cooperative study define the clinicopathological features, genomic transcriptomic landscape, outcomes of rearrangements collected from 29 groups/institutions worldwide. Thirty-four...
Abstract 3D genome alternations can dysregulate gene expression by rewiring enhancer-promoter interactions and lead to diseases. We report integrated analyses of alterations differential expressions in 18 newly diagnosed T-lineage acute lymphoblastic leukemia (T-ALL) patients 4 healthy controls. organizations at the levels compartment, topologically associated domains loop could hierarchically classify different subtypes T-ALL according T cell differentiation trajectory, similar...
PURPOSE Homoharringtonine (HHT) is commonly used for the treatment of Chinese adult AML, and all-trans retinoic acid (ATRA) has been verified in acute promyelocytic leukemia (APL). However, efficacy safety HHT-based induction therapy have not confirmed childhood ATRA-based evaluated among patients with non-APL AML. PATIENTS AND METHODS This open-label, multicenter, randomized Children's Leukemia Group-AML 2015 study was performed across 35 centers China. Patients newly diagnosed AML were...
Abstract We retrospectively compared the outcomes of children with severe aplastic anemia ( SAA ) who received immunosuppressive therapy IST or underwent hematopoietic stem cell transplantation HSCT from a haploidentical donor HID ), between 2007 and 2016. A total 52 under age 17 years were initially treated (n = 24) 28) as first‐line treatment. The estimated 10‐year overall survival was 73.4 ± 12.6% 89.3 5.8% in patients ‐ P .806). failure‐free significantly inferior receiving than those...
Abstract Background Pediatric acute myeloid leukemia (AML) with t(8;21) (q22;q22) is classified as a low-risk group. However, relapse still the main factor affecting survival. We aimed to investigate effect of allogeneic hematopoietic stem cell transplantation (allo-HSCT) on reducing recurrence and improving survival high-risk pediatric AML based minimal residual disease (MRD)-guided treatment, further explore prognostic factors guide risk stratification treatment identify who will benefit...
Objective: Malignancy-associated hemophagocytic lymphohistiocytosis (M-HLH) in children is a relatively rare but life-threatening secondary (sHLH). Until now, only limited number of cases regarding with M-HLH has been reported.Methods: We conducted retrospective study 27 M-HLH, who admitted to our center between July 2007 and October 2019. The clinical data laboratory were analyzed.Results: median age the was 7 years. Underlying diseases included myeloid malignancy (n = 6), lymphoid 18)...
Currently, in China’s power grid, the accounting of carbon emissions has shortcomings such as unclear boundaries, slow updating emission factors (EFs), and a lack spatiotemporal characteristics. In this study, dynamic model for was constructed based on flow theory QIO (Quasi-Input-Output) using transmission side, substation distribution side nodes. By utilizing electricity metering data EF input node, total flowing into node could be calculated. Furthermore, output out The results are...
The prognosis of myeloid sarcoma (MS) is controversial. Many reports indicated that orbital-MS has a good and closely related to t(8;21), but the prognostic role MS in pediatric t(8;21) AML unclear. We retrospectively analyzed data from 127 patients with diagnosed between January 2010 June 2018. compared (n = 30) without 97). median follow-up time was 52.6 months. proportion 23.6%. Males were more likely have than females. complete remission rate after first course induction chemotherapy...
Abstract Myelodysplastic syndrome (MDS) is a heterogeneous group of clonal disorders and rare in children. Allogeneic hematopoietic stem cell transplantation (HSCT) commonly used children with MDS excess blasts patients refractory cytopenia childhood (RCC) associated monosomy 7, complex karyotype, severe neutropenia, or transfusion dependence. We recruited 27 who received haploidentical (haplo‐HSCT). At transplantation, 10 had RCC, 12 advanced (RAEB RAEB‐T), 5 myelodysplasia‐related acute...
The presence of mixed-lineage leukaemia rearrangement (MLL-r) in paediatric patients with acute myeloid (AML) is a poor prognostic predictor. Whether allogeneic haematopoietic stem cell transplantation (allo-HSCT) beneficial such cases remains unclear.We evaluated the outcomes and factors allo-HSCT 44 MLL-r AML first complete remission (CR1) between 2014 2019 at our institution.For all patients, 3-year overall survival (OS), event-free (EFS), cumulative incidence relapse (CIR) were 74.5%,...
In recent years, the Chinese government has focused on doing a good job of "peak carbon dioxide emissions" and "carbon neutrality" work. order to answer call for national green development transformation, an accurate measurement in power grid enterprises is basic premise accurately grasp trend emission effectively carry out various reduction grid, substations, whose loss can account 50% overall loss, have wide range operating equipment some also emissions or leakages sulfur hexafluoride gas....
A six-cyclic crown ether-type pillar[5]arene was synthesized, and the five ethylene oxide loops were located outside cavity not affected by temperature changes which confirmed variable-temperature NMR experiment in DMSO-d6 CDCl
Modern perception systems for autonomous flight are sensitive to occlusion and have limited long-range capability, which is a key bottleneck in improving low-altitude economic task performance. Recent research has shown that the UAV-to-UAV (U2U) cooperative system great potential revolutionize industry. However, lack of large-scale dataset hindering progress this area. This paper presents U2UData, first swarm UAVs flight. The was collected by three flying autonomously U2USim, covering 9...
Stochastic differential equation has accumulated a large number of bases in numeral analysis over decades development. It can accurately and truly reflect some development rules the fields such as economics, physics astronomy when being applied practice. Stability solution is key numerical stochastic equation. In this study, stability was discussed verified. Nonlinear solved using stochastic-θ method under general decay rate, two sufficient conditions were proposed for obtained solutions....