A5077905129- Retinoids in leukemia and cellular processes
- interferon and immune responses
- Acute Myeloid Leukemia Research
- Ubiquitin and proteasome pathways
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Protein Degradation and Inhibitors
- RNA Interference and Gene Delivery
- Autoimmune and Inflammatory Disorders Research
- Advanced biosensing and bioanalysis techniques
- Chronic Lymphocytic Leukemia Research
- Immune Cell Function and Interaction
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- MicroRNA in disease regulation
- Blood groups and transfusion
- Parvovirus B19 Infection Studies
- Synthesis and Characterization of Heterocyclic Compounds
- Cancer, Hypoxia, and Metabolism
- Fungal Plant Pathogen Control
- Hematological disorders and diagnostics
- Blood transfusion and management
- Endoplasmic Reticulum Stress and Disease
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- CAR-T cell therapy research
Nanchang University
2016-2025
First Affiliated Hospital of Jiangxi Medical College
2024-2025
Second Affiliated Hospital of Xi'an Jiaotong University
2025
First Affiliated Hospital of Nanchang University
2015-2024
The University of Texas MD Anderson Cancer Center
2019
Chi Mei Medical Center
2019
Ruijin Hospital
2010-2014
Shanghai Jiao Tong University
2009-2013
Shanghai Institute of Hematology
2009-2013
Abstract Acute myeloid leukemia (AML) with retinoic acid receptor γ (RARG) rearrangement has clinical, morphologic, and immunophenotypic features similar to classic acute promyelocytic leukemia. However, AML RARG is insensitive alltrans (ATRA) arsenic trioxide (ATO) carries a poor prognosis. We initiated global cooperative study define the clinicopathological features, genomic transcriptomic landscape, outcomes of rearrangements collected from 29 groups/institutions worldwide. Thirty-four...
Retinoic acid-induced gene G (RIG-G), a originally identified in all-trans retinoic acid-treated NB4 acute promyelocytic leukemia cells, is also induced by IFNalpha various hematopoietic and solid tumor cells. Our previous work showed that RIG-G possessed potent antiproliferative activity. However, the mechanism for transcriptional regulation of remains unknown. Here, we report signal transducer activator transcription (STAT) 2 together with IFN regulatory factor (IRF)-9 can effectively...
Curcumin, the primary bioactive component isolated from turmeric, has been found to possess a variety of biological functions, including anti-leukemia activity. However, effect curcumin in different leukemia cells vary. In this study, we demonstrated that induced expression AIM2, IFI16, and NLRC4 inflammasomes U937 by increasing levels ISG3 transcription factor complex, which activated caspase 1, promoted cleavage GSDMD, pyroptosis. We also pyroptosis executor GSDMD was not expressed two...
Dysfunction or dysregulation of deubiquitination is closely related to the initiation and development multiple cancers. Targeted regulation has been recognized as an important strategy in tumor therapy. However, mechanism by which drugs regulate deubiquitinase not clear. Here, we identified ubiquitin-specific peptidase 48 (USP48), a member protease family highly expressed various tumors, specific substrate for activated caspase-3. During drug induced apoptosis AML cells, caspase-3 cleaves...
IFN-induced protein with tetratricopeptide repeats 2 (IFIT2), one of the most highly responsive interferon-stimulated genes, inhibits proliferation and migration cancer cells regulates viral replication. IFIT2 has been demonstrated to be a cytoskeleton-associated that becomes enriched in mitotic spindle cells. However, molecular mechanisms by which executes biological functions are largely unclear. The findings this study showed inhibiting activation proteasome led enrichment induced...
Curcumin, the primary bioactive component isolated from turmeric, has been shown to possess variety of biologic functions including anti-cancer activity. However, molecular mechanisms in different cancer cells are various. In present study, we demonstrated that curcumin induced G2/M cell cycle arrest and apoptosis by increasing expression levels cleaved caspase-3, PARP decreasing BCL-2 U937 human leukemic but not K562 cells. We found some interferon genes, especially interferon-induced...
The transcriptional repressor cAMP response element modulator (CREM) has an important role in T-cell development. In this study, we used the integrated Bioinformatics Methods to explore of CREM gastric adenocarcinoma (GAC). Our results showed that high expression was closely related with poorer overall survival GAC. By GSEA cluster analysis, found associated cancer-associated pathway Moreover, single-cell sequencing data is mainly localized exhausted CD8+ T cells. Its prognostic value and...
To explore the plasma metabolomic characteristics of children with transfusion-dependent thalassemia (TDT), and reveal changes metabolic pattern in TDT.
Chronic myeloid leukemia (CML) is a myeloproliferative disorder that accounts for ~10% of all newly diagnosed cases. Early diagnosis essential long‑term beneficial outcomes. The present study observed interferon‑induced protein with tetratricopeptde repeats 2 (IFIT2) expression levels were reduced in bone marrow samples from CML patients compared control using RNA sequencing and reverse transcription‑PCR. IFIT2 restored treated tyrosine kinase inhibitors. To investigate the effect on...
Angioimmunoblastic T-cell lymphoma (AITL) is a subtype of peripheral lymphoma, with heterogenous clinical manifestations and poor prognosis. Here, we report case AITL induced hemophagocytic lymphohistiocytosis (HLH) disseminated intravascular coagulopathy (DIC).An 83-year-old man presented fever purpura both lower limbs for one month. Groin lymph node puncture flow cytometry indicated diagnosis AITL. Bone marrow examination other laboratory related indexes DIC HLH. The patient rapidly...
Although extensive use of tyrosine kinase inhibitors has resulted in high and durable response rate prolonged survival time patients with BCR-ABL1 positive chronic myeloid leukemia (CML) acute leukemia, relapse drug resistance still remain big challenges for clinicians. Monitoring the expression fusion gene identifying ABL mutations are effective means to predict disease resistance. However, prognostic impact signal patterns detected by fluorescence situ hybridization (FISH) remains largely...
The cullin-RING ligase (CRL)-NEDD8 pathway maintains essential cellular processes, including cell cycle progression, apoptosis, autophagy, DNA repair, antigen processing and signal transduction. Growing evidence demonstrates that the alteration of CRL-NEDD8 in some cancers constitutes an attractive target for therapeutic intervention, but roles acute promyelocytic leukemia (APL) is still unclear. In present study, we found ATRA could decrease expression NEDD8-activating enzyme E1 (NAE1)...
Leukemic stem cell (LSC) is thought to be responsible for chronic myelogenous leukemia (CML) initiation and relapse. However, the inherent regulation of LSCs remains largely obscure. Herein, we integratedly analyzed miRNA gene expression alterations in bone marrow (BM) Lin-Sca1+c-Kit+ cells (LSKs) a tet-off inducible CML mouse model, Scl/tTA-BCR/ABL (BA).Scl/tTA TRE-BA transgenic mice were crossed presence doxycycline get double mice. Both mRNA profiles generated from BM LSKs at 0 3 weeks...
Hemophagocytic lymphohistiocytosis (HLH), also termed hemophagocytic syndrome, is a severe, life-threatening inflammatory condition that results from an excessive, prolonged and ineffective immune response. The syndrome occurs due to overactive macrophages the bone marrow or lymph tissue phagocytose erythrocytes leukocytes platelets. HLH in patient with human immunodeficiency virus infection has rarely been studied. present case study described uncommon of this combination patient, who...
Acute promyelocytic leukemia (APL) is characterized by the presence of leukemia-retinoic acid receptor α (PML-RARα) fusion gene, which formed following specific chromosomal translocation t(15;17)(q22;q21). However, cases with PML-RARα generated occult t(15;17) are negative both cytogenetics and fluorescence in situ hybridization (FISH), difficult to diagnose, leading impaired treatment effectiveness. In present study, we reported a case 66-year-old male patient, bone marrow morphology, flow...
To evaluate curative effects of coronavirus disease 2019 (COVID-19) patients by the transfusion other convalescent plasma.Retrospective analysis clinical data 18 with severe and critical COVID-19, who were hospitalized in ICU Xianghu Branch First Affiliated Hospital Nanchang University from February 1 to March 15, 2020. Patients subdivided into an experimental group (n=6, had transfused plasma) observation (n=12, no plasma transfusion). Basic prognosis indexes these two groups compared....
In order to investigate the effect of curcumin combined with all-trans retinoid acid (ATRA) on differentiation ATRA-resistant acute promyelocytic leukemia (APL) cells and its molecular mechanism, NB4-R1, an APL cells, was used as a model, counting NB4-R1 cell morphologic observation were performed, alone or ATRA proliferation, detected by flow cytometry (FCM), change AKT phosphorylation in Western blot. The results showed that had no influence but enhanced inhibitory growth; did not affect...
Abstract Introduction Long noncoding RNA maternally expressed gene 3 ( MEG3 ) expression was significantly decreased in acute myeloid leukemia (AML). However, its and clinical significance promyelocytic (APL) remain unclear. Thus, the present study aimed to investigate of APL explore value. Methods A total 287 AML patients derived from The Cancer Genome Atlas (TCGA) Vizome database were enrolled. development validation cohort, including APL, with AML1/ETO , other types disease controls,...
Thrombocytopenia is common among burn patients. Platelet transfusion frequently administered to increase platelet counts. However, it not clear whether platelets affect the outcome after adult patients with thrombocytopenia or not. Our aim explore affects prognosis of thrombocytopenia. We undertook a retrospective analysis 368 victims from Department Burn at First Affiliated Hospital Nanchang University, China, January 2014 July 2021. Propensity score matching (PSM) was utilized reduce...