A5100401629- CAR-T cell therapy research
- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Chronic Lymphocytic Leukemia Research
- Virus-based gene therapy research
- Cancer Immunotherapy and Biomarkers
- Silicon Carbide Semiconductor Technologies
- Immunotherapy and Immune Responses
- Nanowire Synthesis and Applications
- CRISPR and Genetic Engineering
- Lung Cancer Treatments and Mutations
- Viral Infectious Diseases and Gene Expression in Insects
- T-cell and B-cell Immunology
- Cancer, Lipids, and Metabolism
- Monoclonal and Polyclonal Antibodies Research
- Neuroblastoma Research and Treatments
- Cancer Cells and Metastasis
- Immune cells in cancer
- Ferroptosis and cancer prognosis
- Zebrafish Biomedical Research Applications
- Viral-associated cancers and disorders
- Urinary Bladder and Prostate Research
- Integrated Circuits and Semiconductor Failure Analysis
- Biosimilars and Bioanalytical Methods
- Protein Degradation and Inhibitors
Chengdu Military General Hospital
2024
First Affiliated Hospital of Nanchang University
2021-2023
Nanchang University
2021-2023
Second Military Medical University
2023
National Clinical Research Center for Digestive Diseases
2019-2023
Eastern Hepatobiliary Surgery Hospital
2023
Jiangxi Provincial Academy of Medical Sciences
2023
University of Pennsylvania
2002-2022
HiFiBiO Therapeutics (United States)
2021-2022
California University of Pennsylvania
2020
Responses to therapy with chimeric antigen receptor T cells recognizing CD19 (CART19, CTL019) may vary by histology. Mantle cell lymphoma (MCL) represents a B-cell malignancy that remains incurable despite novel therapies such as the BTK inhibitor ibrutinib, and where data from CTL019 are scant. Using MCL model, we sought build upon outcomes ibrutinib combining these in rational manner.
Abstract Angiogenesis is involved in the pathogenesis of inflammatory arthritis, but little known about role lymphangiogenesis this setting. Here, we examined whether tumor necrosis factor (TNF) stimulates osteoclast precursors (OCPs) to produce lymphatic growth factor, vascular endothelial factor-C (VEGF-C), and induce lymphangiogenesis. We used TNF-transgenic (Tg) mice with serum-induced arthritis. OCPs were purified by fluorescence-activated cell sorting CD11b + /Gr-1 -/lo blood or bone...
A human IL-2 and IL-2Rβ orthogonal cytokine-receptor pair enables a tunable approach to enhancing CAR T cell engraftment antitumor efficacy.
Anaplastic Lymphoma Kinase (ALK) was initially discovered as an oncogene in human lymphoma and other cancers, including neuroblastoma. However, little is known about the physiological function of ALK. We identified alk ortholog zebrafish (Danio rerio) found that it highly expressed developing central nervous system (CNS). Heat-shock inducible transgenic lines were generated to over-express during early neurogenesis. Its ectopic expression resulted activation MEK/ERK pathway, increased cell...
<h3>Background</h3> Chimeric antigen receptor-modified (CAR) T-cell immunotherapy is a novel promising therapy for treatment of B-cell malignancy. Cytokine release syndrome (CRS) and infection are the most common adverse events during CAR therapy. Similar clinical presentation concurrent CRS makes it difficult to differentially diagnose timely treat condition. <h3>Methods</h3> We analyzed features first 30 days after infusion (CTI) in 109 patients from three trials (ChiCTR-OPN-16008526,...
Osteosarcoma (OS) mainly happens in children and youths. Surgery, radiotherapy chemotherapy are the common therapies for osteosarcoma treatment but all their anti-tumor effects limited. In recent years, a new cellular therapy, CAR-T, immunotherapy with genetically engineered T cells bearing chimeric antigen receptor targeting specific tumor-associated antigen, has been proved to be an effective therapy against acute lymphoblastic leukemia. Thus, CAR-T is potentially treatment.A CAR gene...
Antigen heterogeneity that results in tumor antigenic escape is one of the major obstacles to successful chimeric antigen receptor (CAR) T cell therapies solid tumors including glioblastoma multiforme (GBM). To address this issue and improve efficacy CAR therapy for GBM, we developed an approach combines cells with inhibitor apoptosis protein (IAP) antagonists, a new class small molecules mediate degradation IAPs, treat GBM. Here, demonstrated IAP antagonist birinapant could sensitize GBM...
With this study we have demonstrated that in vitro transduction of normal human CD4(+) T lymphocytes with NPM-ALK results their malignant transformation. The transformed cells become immortalized and display morphology immunophenotype characteristic patient-derived anaplastic large-cell lymphomas. These unique features, which are strictly dependent on activity expression, include perpetual cell growth, proliferation, survival; activation the key signal pathways STAT3 mTORC1; expression CD30...
Abstract Inhibitors of Bruton tyrosine kinase (BTK), a downstream BCR, display remarkable activity in subset mantle cell lymphoma (MCL) patients, but the drug resistance remains considerable challenge. In this study, we demonstrate that aberrant expression ROR1 (receptor kinase-like orphan receptor 1), seen large MCL, results BCR/BTK–independent signaling and growth MCL cells. forms functional complex with CD19 to persistently activate key pathways PI3K–AKT MEK–ERK manner. This study...
A fundamental feature of tumor progression is reprogramming metabolic pathways. ATP citrate lyase (ACLY) a key enzyme that catalyzes the generation Acetyl-CoA and upregulated in cancer cells required for their growth. The phosphoinositide 3-kinase (PI3K) Src-family kinase (SFK) Lyn are constitutively activate many cancers. We show here, first time, both substrate product PI3K, phosphatidylinositol-(4,5)-bisphosphate (PIP2) phosphatidylinositol-(3,4,5)-trisphosphate (PIP3), respectively, bind...
The transcriptional repressor cAMP response element modulator (CREM) has an important role in T-cell development. In this study, we used the integrated Bioinformatics Methods to explore of CREM gastric adenocarcinoma (GAC). Our results showed that high expression was closely related with poorer overall survival GAC. By GSEA cluster analysis, found associated cancer-associated pathway Moreover, single-cell sequencing data is mainly localized exhausted CD8+ T cells. Its prognostic value and...
Abstract Current methods to evaluate effects of kinase inhibitors in cancer are suboptimal. Analysis changes metabolism response the creates an opportunity for better understanding interplay between cell signaling and and, from translational perspective, potential early evaluation as well treatment optimization. We performed genomic, metabolomic, fluxomic analyses mechanism action Bruton's tyrosine (BTK) inhibitor ibrutinib (IBR) mantle lymphoma (MCL) cells. Our comprehensive analysis data...
This study aimed to investigate the significance of controlling nutritional status (CONUT) score as a predictor for survival outcomes non-metastatic renal cell carcinoma (RCC) patients.We retrospectively reviewed 325 patients who received surgical treatment between 2010 and 2012 at Peking University First Hospital. Patients were divided into two groups according optimal cut-off value CONUT score. Kaplan-Meier method log-rank test used analysis different groups. Cox proportional hazards...
Abstract Fusion genes including NPM–ALK can promote T-cell transformation, but the signals required to drive a healthy T cell become malignant remain undefined. In this study, we introduce into primary human cells and demonstrate induction of epithelial-to-mesenchymal transition (EMT) program, attenuation most effector programs, reemergence an immature epigenomic profile, dynamic regulation c-Myc, E2F, PI3K/mTOR signaling pathways early during transformation. A mutant failed bind several...
To determine activation status of the IL-2R-associated (Jak/STAT) pathway in HTLV-I infected cells, we examined tyrosine phosphorylation Jak3, STAT3, and STAT5 several (+) T-cell lines uncultured leukemic T cells isolated from patients with adult lymphoma/leukemia (ATLL). Constitutive basal Jak3 and, usually, STAT3 was detected all four IL-2-independent cell tested, but none three IL-2-dependent lines. Similarly, there no detectable ATLL (0/8 0/3, respectively). However, stimulation IL-2...