A5100320009- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Ferroptosis and cancer prognosis
- Pluripotent Stem Cells Research
- Immune cells in cancer
- Cell Adhesion Molecules Research
- Inflammatory mediators and NSAID effects
- Galectins and Cancer Biology
- Cytokine Signaling Pathways and Interactions
- Renal and related cancers
- Natural product bioactivities and synthesis
- Bone health and treatments
- MicroRNA in disease regulation
- Genetic factors in colorectal cancer
- Medicinal Plant Pharmacodynamics Research
- Cancer Immunotherapy and Biomarkers
- Circular RNAs in diseases
- Bone Metabolism and Diseases
- CRISPR and Genetic Engineering
- Cancer, Lipids, and Metabolism
- Prostate Cancer Treatment and Research
Nanjing Medical University
2018-2025
Xiangya Hospital Central South University
2014-2025
Central South University
2013-2025
Shanghai University of Traditional Chinese Medicine
2014-2024
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2014-2024
Guiyang Medical University
2024
Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences
2024
Jiangsu Province Hospital
2018-2024
Nanjing University
2003-2024
Zhejiang University
2022-2024
Background: LncRNA is a key factor influencing tumor development. The present study aimed to investigate the effect of novel lncRNA on progression hepatocellular carcinoma (HCC). Methods: A candidate in Cancer Genome Atlas database was identified using limma and survival R packages. AC099850.3 cell proliferation, apoptosis, migration, invasion, as well its association with immune cells HCC were investigated. Furthermore, functional mechanisms elucidated. Results: aberrant expression tissues...
This study investigated whether Helicobacter pylori could activate the nucleotide-binding oligomerization domain-like receptor (NLR) family, pyrin domain-containing 3 (NLRP3) inflammasome in human macrophages and involvement of reactive oxygen species (ROS) activation. Phorbol-12-myristate-13-acetate (PMA)-differentiated acute monocytic leukemia cell line THP-1 was infected with H. pylori. The levels pro-inflammatory cytokines interleukin (IL)-1β IL-18 supernatant were measured by ELISA....
Bone-related events caused by breast cancer bone metastasis substantially compromise the survival and quality of life patients. Because triple-negative (TNBC) lacks hormone receptors Her2-targeted therapeutic options, progress in treatment TNBC has been very slow. Intercellular adhesion molecule 1 (ICAM1) is highly expressed various cancers plays an important role tumorigenesis metastasis. However, effect mechanism ICAM1 are still unknown. We found that was correlated with prognosis Cell...
Granulomatous lobular mastitis (GLM) is a rare inflammatory breast disease with unknown etiology, characterized by non-caseous granulomatous inflammation of the lobules, which infiltrate lymphocytes, neutrophils, plasma cells, monocytes, and eosinophils may accompany. GLM often misdiagnosed as cancer due to lack specificity in clinical imaging examinations, therefore histopathology main basis for confirming diagnosis. This review provides an overview pathological features cystic neutrophil...
Gut microbiota of centenarians has garnered significant attention in recent years, with most studies concentrating on the analysis microbial composition. However, there is still limited knowledge regarding consistent signatures specific species and their biological functions, as well potential causal relationship between gut longevity. To address this, we performed fecal metagenomic eight longevous populations at functional level, employed Mendelian randomization (MR) to infer associations...
Receptor for Advanced Glycation End Products (RAGE) is an oncogenic trans-membranous receptor overexpressed in various human cancers. However, the role of RAGE breast cancer development and proliferation still unclear. In this study, we demonstrated that expression levels are correlated to degree severity cancer. Furthermore, there a decrease all sub-types cancer, MCF-7, SK-Br-3 MDA-MB-231, as result effect siRNA. siRNA arrested cells G1 phase inhibited DNA synthesis (p < 0.05). Moreover,...
ADP-ribosylation is an important posttranslational protein modification that regulates diverse biological processes, controlled by dedicated transferases and hydrolases. Here, we show frequent deletions (∼30%) of the
Polysaccharide is one of main components in Polygonatum sibiricum (PS), which an herbal medicine widely used East Asia. Polysaccharides from has been shown to exhibit multiple biological activities, such as anti-diabetes, anti-inflammation, antioxidant, immunity modulation, and anticancer. Since hematopoietic system determinant factors cancer control, we here explored the effect polysaccharide-rich extract (PREPS) on hematopoiesis mice bearing triple negative breast (TNBC). We found that 4T1...
Blood glucose (BG) monitoring in patients with diabetes is critical for management. Minimally invasive BG urgently required to increase the patient compliance. Herein, based on a responsive hydrogel system, we developed smart microneedle patch system minimally monitoring. The consisted of transparent substrate photocurable resin and microneedles made pH-responsive glucose-responsive hydrogel. was composed photocrosslinkable gelatin methacrylate (GelMA) together nanogel (nano(CMC-pHEA))...
To compare the embolization outcomes and complications of LEO Baby Neuroform Atlas stents in endovascular treatment intracranial wide-neck aneurysms. We identified patients with aneurysms treated (n=163) or (n=65) stent-assisted coiling between October 2018 February 2023. A retrospective analysis demographics, aneurysm characteristics, outcomes, procedure-related was performed. Propensity score matching a ratio 1:2 used to balance patient selection bias that existed two cohorts. Compared...
The transplantation of embryonic stem cells could improve cardiac function but was limited by immune rejection as well low cell retention and survival within the ischemic tissues. somatic nuclear transfer (SCNT) is practical to generate autologous histocompatible (nuclear-transferred [NTES]) for diseases, NTES may be arguably unsafe therapeutic application. temperature-responsive chitosan hydrogel a suitable matrix in transplantation. As scaffold, coinjected with into left ventricular wall...
Although microRNA-301a (miR-301a) has been reported to function as an oncogene in many human cancers, there are limited data regarding miR-301a and breast tumours. In this study, we first detected the expression of using situ hybridization (ISH) -based classification system 380 samples BC tissue, including both non-TNBC (triple-negative cancer) TNBC specimens. Our results suggest that analysing tissue biopsy specimens at time diagnosis could have potential identify patients who might be...
Background: Doxorubicin (Dox) is one of the most effective chemotherapy agents used in treatment solid tumors and hematological malignancies. However, it causes dose-related cardiotoxicity that may lead to heart failure patients. Luteolin (Lut) a common flavonoid exists many types plants. It has been studied for treating various diseases such as hypertension, inflammatory disorders, cancer. In this study, we evaluated cardioprotective anticancer effects Lut on Dox-induced cardiomyopathy...