A5100757887- Neurobiology and Insect Physiology Research
- Insect and Arachnid Ecology and Behavior
- Animal Behavior and Reproduction
- Atmospheric aerosols and clouds
- Invertebrate Immune Response Mechanisms
- Atmospheric chemistry and aerosols
- Atmospheric Ozone and Climate
- Insect and Pesticide Research
- Circadian rhythm and melatonin
- Insect-Plant Interactions and Control
- Insect Resistance and Genetics
- Atmospheric and Environmental Gas Dynamics
- Insect Pest Control Strategies
- Asthma and respiratory diseases
- Educational Systems and Policies
- interferon and immune responses
- Immune Response and Inflammation
- Genomics and Chromatin Dynamics
- Epigenetics and DNA Methylation
- Genetics, Aging, and Longevity in Model Organisms
- Insect Utilization and Effects
- Diverse Approaches in Healthcare and Education Studies
- Pediatric health and respiratory diseases
- Immune Cell Function and Interaction
- Peptidase Inhibition and Analysis
Yonsei University
2008-2025
Gwangju Institute of Science and Technology
2016-2025
Seoul National University
1997-2024
Mokpo National University
2024
Dong-A University
2024
Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA)
2024
University of Michigan
2024
University of Tsukuba
2024
Inha University Hospital
2024
Sangmyung University
2012-2023
The International Global Atmospheric Chemistry Program (IGAC) has conducted a series of Aerosol Characterization Experiments (ACE) that integrate in situ measurements, satellite observations, and models to reduce the uncertainty calculations climate forcing due aerosol particles. ACE‐Asia, fourth this experiments, consisted two focused components: (1) An intensive field study sought quantify spatial vertical distribution concentrations properties, processes controlling their formation,...
The Geostationary Environment Monitoring Spectrometer (GEMS) is scheduled for launch in February 2020 to monitor air quality (AQ) at an unprecedented spatial and temporal resolution from a geostationary Earth orbit (GEO) the first time. With development of UV–visible spectrometers sub-nm spectral sophisticated retrieval algorithms, estimates column amounts atmospheric pollutants (O3, NO2, SO2, HCHO, CHOCHO, aerosols) can be obtained. To date, all satellite missions monitoring have been low...
Abstract Although approved programmed cell death protein (PD)-1 inhibitors show durable responses, clinical benefits to these agents are only seen in one-third of patients most cancer types. Therefore, strategies for improving the response PD-1 inhibitor treating various cancers including non-small lung (NSCLC) urgently needed. Compared with genome and transcriptome, tumor DNA methylome anti-PD-1 was relatively unexplored. We compared pre-treatment methylation status cis -regulatory elements...
G-protein coupled receptors (GPCRs) are ancient, ubiquitous sensors vital to environmental and physiological signaling throughout organismal life. With the publication of Drosophila genome, numerous “orphan” GPCRs have become available for functional analysis. Here we characterize two groups predicted as peptides with a C-terminal amino acid sequence motif consisting −PRXamide (PRXa). Assuming ligand-receptor coevolution, alternative hypotheses were constructed tested. The insect PRXa...
Corazonin is a highly conserved neuropeptide hormone of wide-spread occurrence in insects yet associated with no universally recognized function. After discovery the corazonin receptor Drosophila , we identified its ortholog moth, Manduca sexta as prelude to physiological studies. The cDNA M. encodes protein 436 amino acids seven putative transmembrane domains and shares common ancestry counterpart. exhibits high sensitivity selectivity for when expressed Xenopus oocytes (EC 50 ≈ 200 pM) or...
At the end of each developmental stage, insects perform ecdysis sequence, an innate behavior necessary for shedding old cuticle. Ecdysis triggering hormones (ETHs) initiate these behaviors through direct actions on CNS. Here, we identify ETH receptor (ETHR) gene in moth Manduca sexta, which encodes two subtypes GPCR (ETHR-A and ETHR-B). Expression ETHRs CNS coincides precisely with acquisition sensitivity to ETHs behavioral competence. ETHR-A occurs diverse networks neurons, producing both...
Upon mating, females of many animal species undergo dramatic changes in their behavior. In Drosophila melanogaster , postmating behaviors are triggered by sex peptide (SP), which is produced the male seminal fluid and transferred to female during copulation. SP modulates via receptor (SPR) located a small subset internal sensory neurons that innervate uterus project CNS. Although required for responses only these neurons, SPR expressed broadly CNS both sexes. Moreover, also encoded genomes...
Significance Successful courtship and reproduction, which are at the center of evolutionary processes, involve complex interactions between neural endocrine systems. In this study, we describe a group neuropeptides that have named “natalisin” (from Latin natalis for “birth”) because their function in promoting reproduction arthropods. Three holometabolous insects, Drosophila melanogaster , Bombyx mori Tribolium castaneum were examined to understand patterns natalisin expression assess...
Probiotic bacteria can induce immune regulation or tolerance in allergic diseases. The underlying mechanisms have been recently investigated, but are still unclear. aim of this study was to evaluate the protective effects probiotic Lactobacillus rhamnosus (Lcr35) a mouse model asthma and identify its mechanism action. Lcr35 administered daily by oral route at dosage 1×10(9) CFU/mouse BALB/c mice for 7 days before first sensitization. Clinical parameters regulatory T (Treg) cells were...
Significance Metazoan species optimize the timing of reproduction to maximize fitness. To understand how biological clocks direct reproduction, we investigated neural substrates that produce oogenesis rhythms in genetically amenable model organism Drosophila melanogaster . The neuropeptide allatostatin C (AstC) is an insect counterpart vertebrate somatostatin, which suppresses gonadotropin production. A subset brain circadian pacemaker neurons produces AstC. We have uncovered these...
Connectomics research has made it more feasible to explore how neural circuits can generate multiple outputs. Female sexual drive provides a good model for understanding reversible, long-term functional changes in motivational circuits. After emerging, female flies avoid male courtship, but they become sexually receptive over 2 d. Mating causes females reject further mating several days. Here, we report that pC1 neurons, which process courtship and regulate copulation behavior, exhibit...
Abstract A field colony of the Two‐spotted spider mite, Tetranychus urticae (Koch), resistant to fenpyroximate was further selected with 5SC for 20 generations at a selection pressure 30–50% mortality (designated as FR‐20 strain). Resistance and cross‐resistance levels strain 18 acaricides were determined using spray method. The extremely [resistance ratio (RR) 252]. exhibited strong positive acrinathrin (RR 196), high resistance benzoximate 55) propargite 64). Moderate 11–40) abamectin,...
The activation of several transcription factors is required for the elimination infectious pathogens via innate immune response. NF-κB, AP-1, and STAT play major roles in synthesis effector molecules during responses. However, fact that these responses can have cytotoxic effects requires their tight regulation to achieve restricted transient activation, mis-regulation damping process has pathological consequences. Here we show AP-1 are themselves inhibitors responsible NF-κB–mediated...
Alzheimer's disease (AD) is the most common type of presenile and senile dementia. The human β-amyloid precursor cleavage enzyme (BACE-1) a key responsible for amyloid plaque production, which implicates progress symptoms AD. Here we assessed anti-BACE-1 behavioral activities curcuminoids from rhizomes Curcuma longa (Zingiberaceae), diarylalkyls curcumin (CCN), demethoxycurcumin (DMCCN), bisdemethoxycurcumin (BDMCCN) against AD Drosophila melanogaster models.Neuro-protective ability was...
Sleep, a reversible quiescent state found in both invertebrate and vertebrate animals, disconnects animals from their environment is highly regulated for coordination with wakeful activities, such as reproduction. The fruit fly, Drosophila melanogaster, has proven to be valuable model studying the regulation of sleep by circadian clock homeostatic mechanisms. Here, we demonstrate that sex peptide receptor (SPR) Drosophila, known its role female reproduction, also important stabilizing males...
Upon mating, fruit fly females become refractory to further mating for several days. An ejaculate protein called sex peptide (SP) acts on uterine neurons trigger this behavioural change, but it is still unclear how the SP signal modifies decision. Here we describe two groups of female-specific local interneurons that are important process-the ventral abdominal lateral (vAL) and medial (vAM) interneurons. Both vAL vAM express myoinhibitory (Mip)-GAL4. positive Mip neuropeptides...
In response to persistent mycobacteria infection, the host induces a granuloma, which often fails eradicate bacteria and results in tissue damage. Diverse receptors are required control formation resolution of but little is known concerning their regulatory interactions. Here we show that Mincle, inducible receptor for mycobacterial cord factor, key switch transition macrophages from cytokine expression high nitric oxide production. addition its stimulatory role on TLR-mediated...
Abstract Vitellogenesis (yolk accumulation) begins upon eclosion and continues through the process of sexual maturation. Upon reaching maturity, vitellogenesis is placed on hold until it induced again by mating. However, mechanisms that gate in response to developmental reproductive signals remain unclear. Here, we have identified neuropeptide allatostatin-C (AstC)-producing neurons both initiation occurs post-eclosion its re-initiation post-mating. During maturation, AstC receive excitatory...