A5000024393- Neurobiology and Insect Physiology Research
- Circadian rhythm and melatonin
- Invertebrate Immune Response Mechanisms
- Biochemical Analysis and Sensing Techniques
- Insect and Arachnid Ecology and Behavior
- Insect Utilization and Effects
- Genetics, Aging, and Longevity in Model Organisms
- Physiological and biochemical adaptations
- Endoplasmic Reticulum Stress and Disease
- Animal Behavior and Reproduction
- RNA regulation and disease
- Olfactory and Sensory Function Studies
- Cellular transport and secretion
- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
- Ubiquitin and proteasome pathways
Gwangju Institute of Science and Technology
2014-2025
Sleep, a reversible quiescent state found in both invertebrate and vertebrate animals, disconnects animals from their environment is highly regulated for coordination with wakeful activities, such as reproduction. The fruit fly, Drosophila melanogaster, has proven to be valuable model studying the regulation of sleep by circadian clock homeostatic mechanisms. Here, we demonstrate that sex peptide receptor (SPR) Drosophila, known its role female reproduction, also important stabilizing males...
In ephaptic coupling, physically adjacent neurons influence one another’s activity via the electric fields they generate. To date, molecular mechanisms that mediate and modulate coupling’s effects remain poorly understood. Here, we show hyperpolarization-activated cyclic nucleotide–gated (HCN) channel lateralizes potentially mutual inhibition between Drosophila gustatory receptor (GRNs). While sweet-sensing GRNs (sGRNs) engage in suppression of bitter-sensing (bGRNs), HCN expression sGRNs...
Metabolism influences locomotor behaviors, but the understanding of neural curcuit control for that is limited. Under standard light-dark cycles, Drosophila exhibits bimodal morning (M) and evening (E) activities are controlled by clock neurons. Here, we showed a high-nutrient diet progressively extended M activity not E activity. tachykinin (DTk) Tachykinin-like receptor at 86C (TkR86C)-mediated signaling was required extension DTk neurons were anatomically functionally connected to...
Appropriate ingestion of salt is essential for physiological processes such as ionic homeostasis and neuronal activity. Generally, low concentrations elicit attraction, while high aversive responses. Here, we observed that sugar neurons in the L sensilla
ABSTRACT Animals sense chemical cues such as nutritious and noxious stimuli through the chemosensory system adapt their behavior, physiology, developmental schedule to environment. In Drosophila central nervous system, interneurons that produce neuropeptides called Hugin (Hug) peptides receive signals from gustatory receptor neurons regulate feeding behavior. Because Hug project axons higher brain region within protocerebrum where dendrites of multiple producing developmentally important are...
The gastrointestinal tract in the adult Drosophila serves as a model system for exploring mechanisms underlying digestion, absorption and excretion, stem cell plasticity, inter-organ communication, particularly through gut-brain axis. It is also useful studying cellular adaptive responses to dietary changes, alterations microbiota immunity, systematic endocrine signals. Despite various types distinct regions tract, few tools are available target manipulate activity of each type region, their...
The rhythmic pattern of biological processes controlled by light over 24 h is termed the circadian rhythm. Disturbance rhythm due to exposure at night (LAN) disrupts sleep-wake cycle and can promote cardiovascular disease, diabetes, cancer, metabolic disorders in humans. We studied how dim LAN affects metabolism using male Drosophila. Wild-type flies exposed 10 lux displayed altered behavior expression patterns genes. In addition, became more vulnerable stress, such as starvation. Whole-body...
Chemosensation is important for the survival and reproduction of animals. The odorant binding proteins (OBPs) are thought to be involved in chemosensation together with chemosensory receptors. While OBPs were initially considered deliver hydrophobic odorants olfactory receptors aqueous lymph solution, recent studies suggest more complex roles various organs. Here, we use
Abstract The endoplasmic reticulum (ER) is a subcellular organelle essential for cellular homeostasis. Perturbation of ER functions due to various conditions can induce apoptosis. Chronic stress has been implicated in wide range diseases, including autosomal dominant retinitis pigmentosa (ADRP), which characterized by age-dependent retinal degeneration caused mutant rhodopsin alleles. However, the signaling pathways that mediate apoptosis response remain poorly understood. In this study, we...
Abstract Sodium is essential for all living organisms. Animals including insects and mammals detect sodium primarily through peripheral taste cells. It not known, however, whether animals can this micronutrient independently of the system. Here, we report that Drosophila IR76b mutants were unable to 1 became capable responding after a period dietary salt deprivation. From screen cells required deprivation-induced preference, identified population anterior enteric neurons named INSO ( In...
The MOZ/MORF histone acetyltransferase complex is highly conserved in eukaryotes and controls transcription, development, tumorigenesis. However, little known about how its chromatin localization regulated. Inhibitor of growth 5 (ING5) tumor suppressor a subunit the complex. Nevertheless, vivo function ING5 remains unclear. Here, we report an antagonistic interaction between Drosophila Translationally controlled protein (TCTP) (Tctp) (Ing5) required for (Enok) H3K23 acetylation. Yeast...