A5084043450- Neurobiology and Insect Physiology Research
- Invertebrate Immune Response Mechanisms
- Animal Behavior and Reproduction
- Genetics, Aging, and Longevity in Model Organisms
- Heat shock proteins research
- Insect Utilization and Effects
- Circadian rhythm and melatonin
- Stress Responses and Cortisol
- Lipid metabolism and biosynthesis
- Aquaculture Nutrition and Growth
- Insect and Arachnid Ecology and Behavior
- Biochemical effects in animals
- Physiological and biochemical adaptations
- Muscle metabolism and nutrition
- Lipid Membrane Structure and Behavior
- Glaucoma and retinal disorders
- Protein Hydrolysis and Bioactive Peptides
- Isotope Analysis in Ecology
- demographic modeling and climate adaptation
- Collembola Taxonomy and Ecology Studies
- Mesenchymal stem cell research
- Cellular transport and secretion
- Cholesterol and Lipid Metabolism
- Plant Reproductive Biology
- Microtubule and mitosis dynamics
University of Shizuoka
2012-2024
University of Tsukuba
2020-2021
Food & Nutrition
2019-2020
Laboratory of Molecular Genetics
2017
University of California, Riverside
2017
National Institutes of Natural Sciences
2015
Okazaki Institute for Integrative Bioscience
2015
National Institute for Basic Biology
2015
Many animals have an intrinsic growth checkpoint during juvenile development, after which irreversible decision is made to upregulate steroidogenesis, triggering the metamorphic juvenile-to-adult transition. However, a molecular process underlying such critical developmental remains obscure. Here we show that nutrient-dependent endocycling in steroidogenic cells provides machinery necessary for activation of metamorphosis Drosophila melanogaster. Endocycle progression prothoracic gland (PG)...
Steroid hormones play key roles in development, growth, and reproduction various animal phyla [1Miller W.L. Auchus R.J. The molecular biology, biochemistry, physiology of human steroidogenesis its disorders.Endocr. Rev. 2011; 32: 81-151Crossref PubMed Scopus (1369) Google Scholar]. insect steroid hormone, ecdysteroid, coordinates growth maturation, represented by molting metamorphosis [2Niwa R. Niwa Y.S. Enzymes for ecdysteroid biosynthesis: their biological functions insects beyond.Biosci....
Significance Metamorphosis is an important biological process by which animals alter their body structures to become sexually mature adults. We discovered that tyramine signaling through the β3-octopamine receptor plays essential role in producing steroid hormone ecdysone, critical for metamorphosis. Based on our observations, we propose monoamine acts downstream of a size checkpoint allows metamorphosis occur only when weight attained during larval development and nutrients are sufficiently...
Abstract Holometabolous insects undergo metamorphosis to reorganize their behavioral and morphological features into adult‐specific ones. In the central nervous system (CNS), some larval neurons programmed cell death, whereas others go through remodeling of axonal dendritic arbors support functions re‐established adult organs. Although there are multiple neuropeptides that have stage‐specific roles in holometabolous insects, reorganization pattern entire neuropeptidergic still remains...
An invertebrate biogenic amine, octopamine, plays diverse roles in multiple physiological processes (e.g. neurotransmitter, neuromodulator, and circulating neurohormone). Octopamine is thought to function by binding G-protein-coupled receptors. In Drosophila, three β-adrenergic-like octopamine receptors (Octβ1R, Octβ2R, Octβ3R) have been identified. We investigated the expression of OctβR genes embryos, larvae, adults. These OctβRs showed distinct patterns central nervous system (CNS)...
Endocycle is a commonly observed cell cycle variant through which cells undergo repeated rounds of genome DNA replication without mitosis. Endocycling arise from mitotic switch the mode, called mitotic-to-endocycle (MES), to initiate growth and terminal differentiation. However, underlying regulatory mechanisms MES remain unclear. Here we used Drosophila steroidogenic organ, prothoracic gland (PG), study MES, critical for PG upregulate biosynthesis steroid hormone ecdysone. We demonstrate...
ABSTRACT Animals sense chemical cues such as nutritious and noxious stimuli through the chemosensory system adapt their behavior, physiology, developmental schedule to environment. In Drosophila central nervous system, interneurons that produce neuropeptides called Hugin (Hug) peptides receive signals from gustatory receptor neurons regulate feeding behavior. Because Hug project axons higher brain region within protocerebrum where dendrites of multiple producing developmentally important are...
<b><i>Background/Aims:</i></b> It is possible that carnosinase (CNDP1) and cellular nonspecific dipeptidase (CNDP2) have important roles in protecting cells tissues against the damage of oxidative stress. Oxidative stress subsequent inflammation are key factors development common chronic metabolic diseases, such as obesity. We aimed to investigate combined effects genetic variations <i>CNDP1</i> <i>CNDP2</i> dietary carbohydrate carotene intake...
Abstract Most fatty acids in phospholipids and other lipid species carry an even number of carbon atoms. Also odd-chain (OCFAs), such as C15:0 C17:0, are widespread throughout the living organism. However, qualitative quantitative profiles OCFAs-containing lipids organisms remain unclear. Here, we show that OCFAs present Drosophila phosphatidylcholine (PC) phosphatidylethanolamine (PE) their level increases accordance with progression growth. Furthermore, found food-derived propionic...
Animals can sense internal nutrients, such as amino acids/proteins, and are able to modify their developmental programs in accordance with nutrient status. In the fruit fly, Drosophila melanogaster , acid/protein is sensed by fat body, an insect adipose tissue, through a sensor, target of rapamycin (TOR) complex 1 (TORC1). TORC1 promotes secretion various peptide hormones from body acid/protein-dependent manner. Fat-body-derived stimulate release insulin-like peptides, which essential...
Animals develop from juveniles to sexually mature adults through the action of steroid hormones. In insect metamorphosis, a surge hormone ecdysone prompts transition larval adult stage. Ecdysone is synthesized by series biosynthetic enzymes that are specifically expressed in an endocrine organ, prothoracic gland. At late stage, expression levels upregulated numerous transcription factors, thus initiating metamorphosis. contrast, mechanism which chromatin regulators support genes largely...
Animals control their developmental schedule in accordance with internal states and external environments. In Drosophila larvae, it is well established that nutrient status sensed by different organs, which turn regulate production of insulin-like peptides thereby growth. contrast, the impact chemosensory system on larval development remains largely unclear. Here, we performed a genetic screen to identify gustatory receptor (Gr) neurons regulating growth development, found Gr28a-expressing...
Increasing oxidative stress seems to be the result of an imbalance between free radical production and antioxidant defenses. During course aging, causes tissue/cellular damage, which is implicated in numerous age-related diseases. Carnosinase (CN or CNDP) dipeptidase, associated with carnosine and/or glutathione (GSH) metabolism, those are most abundant naturally occurring endogenous dipeptide tripeptides scavenger properties. In present study, we generated Drosophila cndp (dcndp) mutant...
Growth and maturation are coordinated by steroid hormone biosynthesis in various animal phyla. The insect hormone, ecdysteroid, coordinates growth maturation, represented molting metamorphosis. In Drosophila melanogaster, prothoracicotropic (PTTH) neurons stimulate generating peak levels of ecdysteroid to trigger maturation. addition, recent studies have shed light on the role PTTH signaling basal biosynthesis, which negatively affects systemic prior However, it remains unclear how is...
<b><i>Introduction:</i></b> In mammals, circadian rhythms regulate many behavioral and physiological processes. Genetic epidemiological studies have shown that dysregulation of the rhythm induces chronic metabolic diseases, such as obesity, diabetes, dyslipidemia. We aimed to know interactions genetic variations seven core clock genes with lifestyle factors on determination parameters. <b><i>Methods:</i></b> analyzed impacts genotype (i.e.,...