A5100417348- Invertebrate Immune Response Mechanisms
- Luminescence and Fluorescent Materials
- Insect symbiosis and bacterial influences
- Insect Utilization and Effects
- Food Quality and Safety Studies
- 2D Materials and Applications
- Molecular Sensors and Ion Detection
- Aquaculture disease management and microbiota
- Neuroscience and Neural Engineering
- Neurobiology and Insect Physiology Research
- Graphene research and applications
- Pluripotent Stem Cells Research
- Studies on Chitinases and Chitosanases
- Nanocomposite Films for Food Packaging
- Entomopathogenic Microorganisms in Pest Control
- Meat and Animal Product Quality
- MXene and MAX Phase Materials
- Plant Disease Resistance and Genetics
- Dendrimers and Hyperbranched Polymers
- Parasites and Host Interactions
- Biochemical Analysis and Sensing Techniques
- Asthma and respiratory diseases
- Ion channel regulation and function
- Immune cells in cancer
- Advanced biosensing and bioanalysis techniques
Yonsei University
2024
CHA University
2024
National Institute of Biological Resources
2023
Korea Advanced Institute of Science and Technology
2020-2022
Sookmyung Women's University
2022
Seoul National University
2011-2021
Chosun University
2019
Korea Institute of Toxicology
2017-2018
Korea Research Institute of Chemical Technology
2017-2018
Pusan National University
2011-2015
The symbiotic microbiota profoundly affect many aspects of host physiology; however, the molecular mechanisms underlying host-microbe cross-talk are largely unknown. Here, we show that pyrroloquinoline quinone-dependent alcohol dehydrogenase (PQQ-ADH) activity a commensal bacterium, Acetobacter pomorum, modulates insulin/insulin-like growth factor signaling (IIS) in Drosophila to regulate homeostatic programs controlling developmental rate, body size, energy metabolism, and intestinal stem...
We investigated the intramolecular charge transfer characteristics in S1 state of boron-dipyrromethene (BODIPY) derivatives with triphenylamine (TPA) substituents, depending on substituted position and number substituents. Based spectroscopic theoretical results, β-substitution TPA BODIPY hybridizes locally excited because strong coupling between highest occupied molecular orbitals moieties, consequently, β-substituted TPAs exhibit red-color fluorescence around 640 nm nonpolar moderately...
Intestinal dual oxidase (DUOX) activation is the first line of host defense against enteric infection in Drosophila. DUOX enzymatic activity mainly controlled by phospholipase C-β (PLCβ)-dependent calcium mobilization, whereas gene expression MEKK1-p38 mitogen-activated protein kinase pathway. Furthermore, bacterial-derived uracil molecules act as ligands for activation. However, our current understanding uracil-induced signal transduction pathways remain incomplete. We have recently found...
With the severity of chronic kidney disease worldwide, strategies to recover renal function via tissue regeneration provide alternatives replacement therapy. To exclude side effects from direct cell transplantation, extracellular vesicles (EVs) are great substitutes representing paracrine signaling. build three-dimensional structures for implantation into 5/6 nephrectomy model by incorporating bioactive materials, including multifunctional EVs (mEVs), porous PMEZE/mEV scaffolds were...
A cationic conjugated polyelectrolyte was designed and synthesized based on poly(fluorene-co-phenylene) containing 5 mol% benzothiadiazole (BT) as a low energy trap 15-crown-5 recognizing group for potassium ions. ion can form sandwich-type 2:1 Lewis acid-based complex with 15-crown-5, to cause the intermolecular aggregation of polymers. This facilitates inter-chain fluorescence resonance transfer (FRET) low-energy BT segment, resulting in fluorescent signal amplification, even at dilute...
Commensalibacter intestini A911(T), a predominant symbiotic bacterium capable of stably colonizing gut epithelia, was isolated from the fruit fly, Drosophila melanogaster. Here we report draft genome sequence A911(T).
The gastrointestinal tract in the adult Drosophila serves as a model system for exploring mechanisms underlying digestion, absorption and excretion, stem cell plasticity, inter-organ communication, particularly through gut-brain axis. It is also useful studying cellular adaptive responses to dietary changes, alterations microbiota immunity, systematic endocrine signals. Despite various types distinct regions tract, few tools are available target manipulate activity of each type region, their...
We report self-assembled polymeric nanovesicles composed of 1,4-bis{4′-[N,N-bis(6′′-trimethylammoniumhexyl)amino]styryl}benzene tetrabromide (C1), poly[(ethylene oxide)-block-(sodium 2-acrylamido-2-methyl-1-propane sulfonate)] (Em-An), and hexadecyltrimethylammonium bromide (C16). Transmission electron microscopy (TEM) micrographs confirm the vesicular bilayer structures atomic force (AFM) images show that C1/Em-An/C16 complexes form spherical nanostructures with a particle size ranging from...
Today's circuit technology requires low-power transistors and diodes to extend Moore's law. While research has been focused on reducing power consumption of transistors, have not widely studied. Here, we report a low-power, thus steep-slope Schottky diode, with “cold metal” source. The barrier between metal electrode bulk MoS2 enabled the diode behavior, IV curve originated from change in density states graphite (cold metal) source bias voltage. cold exhibits an ideality factor (η) <...
This study was conducted to determine the effect of heat treatment (searing and reverse searing) on volatile components physicochemical sensory characteristics beef tenderloin. In reverse-seared steaks (RSSs), loss rate lower than in seared steak (SS), several free amino acids (glutamic acid, glycine, histidine, anserine) were increased, while a decrease fatty (FAs) compounds (VCs) observed. The VCs identified as 24 compounds: 11 aldehydes, 5 alcohols, 1 ketone, furan, 6 aliphatic...
This study concentrates on the potential application of conjugated polyelectrolytes (CPEs) to cell imaging and DNA delivery. Four different types polyfluorene copolymers, namely, PAHFP-Br, PAEFP-Br, PAHFbT-Br, PSBFP-Na, which have same π-conjugated backbone but side chains, were synthesized. For cytotoxicity testing, L-929 fibroblastic cells treated with increasing concentrations (0–50 µM) each CPE then viability was determined by WST-8 assay. Cellular uptake CPEs into cultured observed...
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Three types of cationic polyfluorenes with a different number ionic groups are synthesized to modulate their solubility in water and the interactions anionic oligonucleotide probes (DNA‐C). Increasing charge density improves water‐solubility conjugated polyelectrolytes (CPEs) but decreases its optical antenna effect electrostatic sensory platform (CPE/DNA‐C), resulting low fluorescence resonance energy transfer (FRET) signal. With increasing CPE, concentration units CPE/DNA‐C at [+]:[−] =...
The objectives of this study was to determine whether a new physically modified cornstarch by ultra-fine- or nanoscale pulverizer reduce particle size offers better bioactive function than native in weanling SpragueDawley rats. Male weaning Sprague-Dawley rats were fed diets containing (NAC), ultra fine pulverized (UFC) nano-scale (NSC) for 4 weeks. In vitro rate starch hydrolysis, growth performance, organ weight, intestine length intestinal proliferation and the fermentation...