A5074702809- Foot and Ankle Surgery
- Orthopedic Surgery and Rehabilitation
- Spine and Intervertebral Disc Pathology
- Infectious Diseases and Tuberculosis
- Spinal Fractures and Fixation Techniques
- Musculoskeletal pain and rehabilitation
- Bone health and osteoporosis research
- Tendon Structure and Treatment
- Sports injuries and prevention
- Orthopedic Infections and Treatments
- Anesthesia and Pain Management
- Bone and Joint Diseases
- Spinal Dysraphism and Malformations
- Pelvic and Acetabular Injuries
- Teratomas and Epidermoid Cysts
- Musculoskeletal synovial abnormalities and treatments
- Scoliosis diagnosis and treatment
- Bone Tissue Engineering Materials
- Myofascial pain diagnosis and treatment
- Pain Management and Opioid Use
- Extracellular vesicles in disease
- Folate and B Vitamins Research
- Knee injuries and reconstruction techniques
- Shoulder Injury and Treatment
- Bone Metabolism and Diseases
CHA University
2015-2024
CHA Bundang Medical Center
2015-2024
Seoul National University
2020
Baylor College of Medicine
2019
Adipose tissue-derived mesenchymal stem cells (AT-MSCs) offer potential as a therapeutic option for chronic discogenic low back pain (LBP) because of their immunomodulatory functions and capacity cartilage differentiation. The goal this study was to assess the safety tolerability single intradiscal implantation combined AT-MSCs hyaluronic acid (HA) derivative in patients with LBP. We performed single-arm phase I clinical trial 12-month follow-up enrolled 10 eligible LBP patients. Chronic had...
Abstract Osteoporotic vertebral compression fractures (OVCFs) are serious health problems. We conducted a randomized, open-label, phase I/IIa study to determine the feasibility, safety, and effectiveness of Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) teriparatide (parathyroid hormone 1-34) in OVCFs. Twenty subjects with recent OVCFs were randomized (20 μg/day, daily subcutaneous injection for 6 months) treatment alone or combined WJ-MSCs (intramedullary [4 × 107 cells]...
Tauroursodeoxycholic acid (TUDCA) is a US FDA-approved hydrophilic bile for the treatment of chronic cholestatic liver disease. In present study, we investigate effects TUDCA on proliferation and differentiation osteoblasts its therapeutic effect mice model osteoporosis. Following with different concentrations TUDCA, cell viability, differentiation, mineralization were measured. Three-month-old female C57BL/6 randomly divided into three groups (n = 8 per group): (i) normal as control group,...
Extracellular vesicles (EVs) possess the characteristics of their parent cells, based on which various studies have actively investigated treatments for diseases using mesenchymal stem cell-derived EVs due to regenerative activity. Furthermore, in recent years, there been significant efforts engineer improve native activities and integrate additional functions. Although both endogenous exogenous methods are used engineering EVs, may pose problem administering substances cells undergoing...
ABSTRACT Genetic factors have been shown to be a small but significant predictor for osteoporosis and osteoporotic fracture risk. We performed case–control association study determine the between miR‐146a , miR‐149 miR‐196a2 miR ‐499 polymorphisms vertebral compression (OVCF) susceptibility. In total, 286 unrelated postmenopausal Korean women (57 with OVCFs, 55 non‐OVCFs, 174 healthy controls) were recruited. All subjects underwent dual energy X‐ray absorptiometry BMD at lumbar spine femoral...
The purpose of this study was to evaluate the change in sagittal tibiotalar alignment after total ankle arthroplasty (TAA) for osteoarthritis and investigate factors affecting restoration alignment. This retrospective included 119 patients (120 ankles) who underwent three component TAA using Hintegra prosthesis. A 63 ankles had anterior displacement talus before surgery (group A), 49 normal range B), eight posterior C). Ankles group were further sub-divided into those whom restored following...
Purpose: We wanted to investigate the grip and pinch strength of hands establish clinical normative data for Korean people. Materials Methods: A sample 234 males 281 females (age: 10 84) were tested. Grip tested twice with 5 minute interval between tests. Results: Generally, hand peaked at 30 39 age both females. The average was 48.8 ㎏ 28.23 they 11 % stronger than 12 years before in groups. Tip forties, but key tripod thirties. All peak obtained group Among strengths, strongest. For...
It was reported that substance P had beneficial effects in the healing of acute tendon injury. However, relationship between and degenerative tendinopathy development remains unclear. The purpose this study to determine role pathogenesis tendinopathy. Healthy were harvested from human tenocytes cultured individually. expression levels genes associated with compared. Next, exogenously administered healthy tenocyte effect evaluated. results showed higher COL3A1, MMP1, COX2, SCX, ACTA2, gene...
As life expectancy increases, the prevalence of osteoporosis is increasing. In addition to vitamin D which well established have an association with osteoporosis, B vitamins, such as thiamine, folate (vitamin B9), and cobalamin B12), could affect bone metabolism, quality, fracture risk in humans by influencing homocysteine/folate metabolism. Despite crucial role vitamins there are few studies regarding associations between vitamin-related genes osteoporosis. this study, we investigated...
With the severity of chronic kidney disease worldwide, strategies to recover renal function via tissue regeneration provide alternatives replacement therapy. To exclude side effects from direct cell transplantation, extracellular vesicles (EVs) are great substitutes representing paracrine signaling. build three-dimensional structures for implantation into 5/6 nephrectomy model by incorporating bioactive materials, including multifunctional EVs (mEVs), porous PMEZE/mEV scaffolds were...
Abstract Achieving satisfactory bone tissue regeneration in osteoporotic patients with ordinary biomaterials is challenging because of the decreased mineral density and aberrant microenvironment. In addressing this issue, a biomimetic scaffold (PMEH/SP), incorporating 4‐hexylresorcinol (4HR), substance P (SP) into poly(lactic‐go‐glycolic acid) (PLGA) magnesium hydroxide (M) extracellular matrix (E) introduced, enabling consecutive release bioactive agents. 4HR SP induced phosphorylation p38...
Postmenopausal osteoporosis is one of the most prominent diseases in postmenopausal women and it increasing prevalence with aging population. Furthermore, osteoporotic vertebral compression fractures (OVCFs) are related to mortality decreased quality life. Therefore, searching for biomarkers that able identify who at high risk developing OVCFs an effective strategy improving life patients alleviating social economic burdens. In this study, we investigated methylenetetrahydrofolate reductase...
Infectious spondylitis is a rare but severe disease of the spine caused by bacteria or other pathogens. Particularly in immunocompromised patients, definitive source infection often remains uncertain. Among many pathogens, Streptococcus gordonii, normal oral flora, very pathogen infectious spondylitis. Only few articles have reported gordonii. To best our knowledge, there been no reports surgically treated Hence, current report, we present case 76-year-old woman with known type 2 diabetes...
High-grade spondylolisthesis at the cervicothoracic junction is rare and can cause devastating spinal cord injuries. Here, authors describe two patients who presented with high-grade without neurological deficit level C7/T1. Cervicothoracic instability was stabilized circumferential fusion no further deficits. Key words: Trauma; Spondylolisthesis;
Ahn, Tae-Keun MD; Yi, Young Cho, Jae-Ho Lee, Woo-Chun MD, PhD Author Information