A5088037220- MicroRNA in disease regulation
- Reproductive System and Pregnancy
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Pregnancy and preeclampsia studies
- Folate and B Vitamins Research
- Endometriosis Research and Treatment
- Blood Coagulation and Thrombosis Mechanisms
- Liver Disease Diagnosis and Treatment
- Genetic Mapping and Diversity in Plants and Animals
- Ectopic Pregnancy Diagnosis and Management
- RNA modifications and cancer
- Genetic Associations and Epidemiology
- Protease and Inhibitor Mechanisms
- Bone health and osteoporosis research
- Biochemical and Molecular Research
- Cancer, Hypoxia, and Metabolism
- Reproductive Biology and Fertility
- Esophageal and GI Pathology
- Prenatal Screening and Diagnostics
- Glioma Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Cerebrovascular and genetic disorders
- Lung Cancer Treatments and Mutations
- Cholesterol and Lipid Metabolism
Seoul National University Hospital
2024
CHA University
2014-2023
IQVIA (United Kingdom)
2023
Hallym University
2022
Hallym University Dongtan Sacred Heart Hospital
2022
Theragen
2020-2021
Amorepacific (South Korea)
2021
Yonsei University
2020
Gangnam Severance Hospital
2020
Oregon Health & Science University
2020
All cancers harbor molecular alterations in their genomes. The transcriptional consequences of these somatic mutations have not yet been comprehensively explored lung cancer. Here we present the first large scale RNA sequencing study adenocarcinoma, demonstrating its power to identify point as well variants such gene fusions, alternative splicing events, and expression outliers. Our results reveal genetic basis 200 adenocarcinomas Koreans including deep characterization 87 surgical specimens...
Data from 55 consecutive patients with low-grade astrocytomas treated between 1982 and 1990 were analyzed to determine specific outcome factors, including time recurrence, incidence of anaplastic transformation, survival. Gender, type symptoms, contrast enhancement, timing radiation therapy not significant in determining outcome. Patients who had symptoms for > 2 years underwent gross-total resection the tumor, age as a continuous variable, associated significantly longer recurrence Within...
Abstract Premature ovarian failure ( POF ) is a major side effect of chemotherapy in young cancer patients. To develop pharmaceutical agents for preserving fertility, it necessary to understand the mechanisms responsible chemotherapy‐induced follicle loss. Here, we show that treatment with cisplatin, widely used anticancer drug, depleted dormant pool mouse ovaries by excessive activation primordial follicles, without inducing follicular apoptosis. Moreover, co‐treatment antioxidant melatonin...
Small non‑coding microRNAs (miRNAs) are not only important for heart and vascular development but also in cardiovascular pathophysiology diseases, such as ischemia atherosclerosis‑related diseases. However, the effect of miR‑146a, miR‑149, miR‑196a2 miR‑499 polymorphisms on coronary artery disease (CAD) susceptibility remain unknown. The aim present study was to examine genotype frequencies patients with CAD, assess their clinical applications diagnosing monitoring CAD. Using polymerase...
MicroRNAs play an important role in cancer initiation and development. The aim of this study was to investigate whether polymorphisms miRNA machinery genes are associated with the development colorectal (CRC). RAN rs14035 CT heterozygotes T allele carriers (CT + TT) genotypes had lower risk CRC, while DICER1 rs3742330, DROSHA rs10719, XPO5 rs11077 were not CRC full sample. Specifically, male AA genotype (CT/AA) experienced reduced susceptibility (both colon rectal). Subgroup analysis...
Objective MicroRNAs (miRNAs) regulate gene expression during the peri-implantation period. The purpose of this study was to investigate whether genetic polymorphisms in four miRNAs associated with fetal or placental development play roles idiopathic recurrent pregnancy loss (RPL) Korean females. Study design A case-control involving 225 controls and 387 women at least two consecutively losses between 1999 2012 performed. genotypes miRNA polymorphisms, including miR-27a rs895819, miR-423...
In colorectal carcinogenesis, the unique molecular and genetic changes that occur within cells result in specific CRC phenotypes. The involvement of long non-coding RNA, HOTAIR, cancer development, progression, metastasis is well established. Various studies have reported on contribution HOTAIR to pathogenesis. Therefore, we selected four polymorphisms (rs7958904G>C, rs1899663G>T, rs4759314A>G, rs920778T>C) evaluate association each variant with prevalence prognosis. We conducted a...
Abstract Adequate bowel preparation is an important factor in high-quality colonoscopy. It generally accepted that a Boston Bowel Preparation Scale (BBPS) score ≥ 6 adequate, but some reports suggest 7. Subjects who underwent colonoscopy at least twice within 3 years from August 2015 to December 2019 were included. Polyp detection rates (PDRs), adenoma (ADRs), and number of polyps including adenomas compared stratified by baseline (C1) BBPS score. Among 2352 subjects, 529 had (group 1) 1823...
Recurrent pregnancy loss (RPL) is defined as two or more consecutive losses prior to 20 weeks of gestation, and the incidence RPL estimated at 1% all pregnancies. While etiologies are diverse, immune function considered be an important cause RPL. In particular, complement system essential for stable development placenta fetus. Moreover, factor D (CFD) H (CFH) regulators associated with diseases, such age-related macular degeneration. Therefore, we investigated whether polymorphisms CFD CFH...
Abstract Background Hypertension (HTN), diabetes mellitus (DM), and dyslipidemia (DL) are well-known risk factors of cardiovascular disease (CVD), but not all patients develop CVDs. Studies have been limited investigating genetic CVDs specific to individuals with metabolic diseases. This study aimed identify disease-specific and/or common loci associated CVD susceptibility in chronic patients. Methods We conducted a genome-wide association (GWAS) multiple case–control design data from the...
MicroRNAs (miRNAs or miRs) are small (19-23 nt) non-coding RNA molecules that endogenous regulators of gene expression. Previous studies have found some miRNAs related to the progression ischemia in cerebral artery. Furthermore, a recent study significant association between miRNA single nucleotide polymorphisms (SNPs) and risk ischemic stroke. Therefore, it may be valuable investigate associations megakaryocyte formation-related prevalence We thus conducted case-control 1,000 individuals...
Abstract Understanding the mechanisms underlying metabolically unhealthy normal weight (MUHNW) and healthy obese (MHO) phenotypes is important for developing strategies to prevent cardiometabolic diseases. Here, we conducted genome-wide association studies (GWASs) identify MUHNW MHO genetic indices. The study dataset comprised single-nucleotide polymorphism genotypes epidemiological data from 49,915 subjects categorised into four phenotypes—metabolically (MHNW), MUHNW, MHO, (MUHO). We two...
The dynamics of focal adhesions (FAs) are essential physiological processes involved in cell spreading, metastasis, and regulation the actin cytoskeleton. FAs complex structures comprising proteins, such as paxillin zyxin, which interact with extracellular membranes influence motility morphology. Although related studies have been reported various cancers, function molecular mechanisms oral squamous carcinoma (OSCC) remain unknown. We investigated coordination between cytoskeleton FA...
The aim of our study was to investigate whether polymorphisms in microRNA machinery genes are associated with the risk primary ovarian insufficiency (POI).We genotyped 136 POI patients and 236 controls among Korean women for nine single nucleotide (SNPs; DROSHA rs6877842 rs10719; DICER1 rs13078 rs3742330; RAN rs14035; XPO5 rs34324334, rs2257082, rs11544382, rs11077) by polymerase chain reaction-restriction fragment length polymorphism analysis. Differences genotype frequencies between were...
Single-nucleotide polymorphisms (SNPs) in microRNA machinery genes might affect processing and subsequently impact tumorigenesis. The aim of this study was to investigate the associations between SNPs hepatocellular carcinoma (HCC) a Korean population. Genotyping six performed using blood samples from 147 patients with HCC 209 healthy control subjects. None were significantly associated development. However, among models for polymorphic loci-DICER (rs3742330 rs13078), DROSHA (rs10719...
The one-carbon metabolism pathway disorder was important role in successful pregnancy. MTHFR and TS protein were crucial factor metabolism. To investigate the association between recurrent implantation failure (RIF) enzymes pathway. A total of 120 women diagnosed with RIF 125 control subjects genotyped for 677C>T, 1298A>C, TSER 2R/3R 1494del/ins by a polymerase chain reaction-restriction fragment length polymorphism assay. According to gene-gene combination analysis, 677/MTHFR 1298 (TT/AA)...
The microRNA (miRNA) is a small non-coding RNA molecule that modulates gene expression at the posttranscriptional level. Platelets have crucial role in both hemostasis and thrombosis, condition can occlude cerebral artery cause ischemic stroke. miR-130b, miR-200b, miR-495 are potential genetic modulators involving platelet production activation. We hypothesized single nucleotide polymorphisms (SNPs) these miRNAs might potentially contribute to susceptibility stroke post-stroke mortality....
ABSTRACT Genetic factors have been shown to be a small but significant predictor for osteoporosis and osteoporotic fracture risk. We performed case–control association study determine the between miR‐146a , miR‐149 miR‐196a2 miR ‐499 polymorphisms vertebral compression (OVCF) susceptibility. In total, 286 unrelated postmenopausal Korean women (57 with OVCFs, 55 non‐OVCFs, 174 healthy controls) were recruited. All subjects underwent dual energy X‐ray absorptiometry BMD at lumbar spine femoral...
Although a founder variant of RNF213 4810G>A is major genetic risk factor for moyamoya disease (MMD) in East Asians, the frequency and susceptibility variants remain largely unknown. This study investigated mutation analysis (4448, 4810, 4863, 4950) between Korean MMD healthy controls. We performed polymerase chain reaction-restriction fragment length polymorphism analysis. To identify association gene polymorphisms disease, we statistical analyses such as multivariable logistic regression...
MicroRNA (miRNA) expression has been examined in multiple conditions, including various cancers, neurological diseases, and cerebrovascular particularly stroke. Existing evidence indicates that miRNA biosynthesis function play crucial roles ischemic stroke physiology pathology. In this study, we selected six known polymorphisms miRNA-biogenesis genes; DICER rs13078A>T, rs3742330A>G; DROSHA rs10719T>C, rs6877842G>C; Ran GTPase (RAN) rs14035C>T; exportin 5 (XPO5) rs11077A>C.We analyzed the...