A5077627627- Ion channel regulation and function
- Atmospheric chemistry and aerosols
- Fuel Cells and Related Materials
- Neuroinflammation and Neurodegeneration Mechanisms
- Advancements in Solid Oxide Fuel Cells
- Air Quality Monitoring and Forecasting
- Immune Response and Inflammation
- Medicinal Plants and Neuroprotection
- Air Quality and Health Impacts
- Spinal Cord Injury Research
- Electrocatalysts for Energy Conversion
- Neurological Disease Mechanisms and Treatments
- Robot Manipulation and Learning
- Urban Heat Island Mitigation
- S100 Proteins and Annexins
- Diabetic Foot Ulcer Assessment and Management
- MicroRNA in disease regulation
- Building Energy and Comfort Optimization
- Pregnancy-related medical research
- RNA Interference and Gene Delivery
- Conducting polymers and applications
- Cannabis and Cannabinoid Research
- Bone and Joint Diseases
- Nicotinic Acetylcholine Receptors Study
- Inflammasome and immune disorders
Ulsan National Institute of Science and Technology
2024
Yonsei University
2016-2023
CHA Bundang Medical Center
2017-2019
CHA University
2017-2019
Daegu Gyeongbuk Institute of Science and Technology
2019
Korea Institute of Energy Research
2010-2011
Anoctamin1 (ANO1)/transmembrane protein 16A (TMEM16A), a calcium-activated chloride channel (CaCC), is involved in many physiological functions such as fluid secretion, smooth muscle contraction, nociception and cancer progression. To date, only few ANO1 inhibitors have been described, these low potency selectivity for ANO1. Here, we performed high-throughput screening to identify highly potent selective small molecule of Three novel were discovered from 54,400 synthetic molecules, they...
Human mesenchymal stem cell (hMSC)-derived exosomes have been spotlighted as a promising therapeutic agent for cell-free regenerative medicine. However, poor organ-targeting ability and insufficient efficacy of systemically injected hMSC-exosomes were identified critical limitations their further applications. Therefore, in this study we fabricated iron oxide nanoparticle (IONP)–incorporated exosome-mimetic nanovesicles (NV-IONP) from IONP-treated hMSCs evaluated clinically relevant model...
The aim of this study was to investigate the anti-inflammatory effects Ursodeoxycholic acid (UDCA) in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages.We induced an inflammatory process macrophages using LPS. UDCA on LPS-stimulated were analyzed nitric oxide (NO). Pro-inflammatory and cytokines by quantitative real time polymerase chain reaction (qRT-PCR) enzyme-linked immunosorbent assay (ELISA). phosphorylations extracellular signal-regulated kinase (ERK), c-Jun N-terminal (JNK),...
Anoctamin1 (ANO1), a calcium-activated chloride channel, is involved in the proliferation, migration, and invasion of various cancer cells including head neck squamous cell carcinoma, lung cancer, prostate cancer. Inhibition ANO1 activity or downregulation expression these known to exhibit anticancer effects. Resveratrol, natural polyphenol abundant wines, grapes, berries, soybeans, peanuts, shows wide variety biological effects anti-inflammatory, antioxidant, activities. In this study, we...
This study aimed to investigate the anti-inflammatory effects of tauroursodeoxycholic acid (TUDCA) after spinal cord injury (SCI) in rats. We induced an inflammatory process RAW 264.7 macrophages, BV2 microglial cells, and bone marrow-derived macrophages (BMM) using lipopolysaccharide (LPS). The TUDCA on LPS-stimulated BMMs were analyzed nitric oxide (NO) assays, quantitative real-time polymerase chain reactions (qRT-PCR), enzyme-linked immunosorbent assays (ELISA). pathological changes...
ABSTRACT Genetic factors have been shown to be a small but significant predictor for osteoporosis and osteoporotic fracture risk. We performed case–control association study determine the between miR‐146a , miR‐149 miR‐196a2 miR ‐499 polymorphisms vertebral compression (OVCF) susceptibility. In total, 286 unrelated postmenopausal Korean women (57 with OVCFs, 55 non‐OVCFs, 174 healthy controls) were recruited. All subjects underwent dual energy X‐ray absorptiometry BMD at lumbar spine femoral...
α-Asarone, a bioactive compound found in Acorus plant species, has been shown to exhibit neuroprotective, anti-oxidative, anti-inflammatory and cognitive-enhancing effects. However, the effects of α-asarone on spinal cord injury (SCI) have not yet elucidated. The present study investigated mRNA pro-inflammatory cytokines, macrophage polarization towards an M2 phenotype, angiogenesis rats with compressive SCI. α-Asarone was orally administered (10 mg/kg) once per day for 14 days following...
This paper proposes a novel switch control for the series elastic actuator (SEA). provides more robust position along with better impulse dissipation performance. SEA is an technology commonly used in robotic applications that require safe and precise interaction control. The has built-in spring elements to inherently measure or estimate transmitted force. It often application where relevant action between motion force needed. switching problem torque one of major issues, especially...
Phase transitions in dissipative quantum systems have been investigated using various analytical approaches, particularly the mean-field (MF) limit. However, results often depend on specific methodologies. For instance, Keldysh formalism shows that transverse Ising (DTI) model exhibits a discontinuous transition at upper critical dimension, $d_c= 3$, whereas fluctuationless MF approach predicts continuous infinite dimensions ($d_\infty$). These two solutions cannot be reconciled because...
Abstract not Available.
Abstract not Available.