A5100673994- Conducting polymers and applications
- Electrochemical Analysis and Applications
- Electrochemical sensors and biosensors
- Analytical Chemistry and Sensors
- Advanced biosensing and bioanalysis techniques
- Neuroscience and Neural Engineering
- Photoreceptor and optogenetics research
- Molecular Communication and Nanonetworks
- Advanced Sensor and Energy Harvesting Materials
- Photonic and Optical Devices
- Polymer Surface Interaction Studies
- Molecular Junctions and Nanostructures
- Electrospun Nanofibers in Biomedical Applications
- Petroleum Processing and Analysis
- bioluminescence and chemiluminescence research
- Microfluidic and Capillary Electrophoresis Applications
- Photorefractive and Nonlinear Optics
- Photopolymerization techniques and applications
- 3D Printing in Biomedical Research
- Biochemical Analysis and Sensing Techniques
- Liquid Crystal Research Advancements
- melanin and skin pigmentation
- Hydrocarbon exploration and reservoir analysis
- Olfactory and Sensory Function Studies
- Mass Spectrometry Techniques and Applications
Yonsei University
2005-2025
University of Maryland, College Park
2016-2025
World Health Organization - Pakistan
2023-2024
Institute for Bioscience and Biotechnology Research
2011-2024
Chosun University Hospital
2024
Sungkyunkwan University
2007-2023
Samsung Medical Center
2007-2023
Advanced Bioscience Laboratories (United States)
2023
Research Institute for Bioscience and Biotechnology
2023
Seoul National University
2012-2022
Abstract The ability to interconvert information between electronic and ionic modalities has transformed our record actuate biological function. Synthetic biology offers the potential expand communication ‘bandwidth’ by using biomolecules providing electrochemical access redox-based cell signals behaviours. While engineered cells have transmitted molecular devices, for bidirectional stands largely untapped. Here we present a simple electrogenetic device that uses redox carry bacterial in...
Self-powered energy harvesters utilizing triboelectric effect and electrostatic induction have been widely studied, leading in the materials viewpoint to numerous material pairs for facile charge separation upon repetitive contacts with elaborate topological structures. Here, we present a simple but robust platform based on molecularly engineered surface nanogenerator by self-assembled monolayers (METS). Triboelectric density of substrate was readily controlled variation end-functional...
Individually, advances in microelectronics and biology transformed the way we live our lives. However, there remain few examples which electronics have been interfaced to create synergistic capabilities. We believe are two major challenges integration of biological components into microelectronic systems: (i) assembly at an electrode address, (ii) communication between assembled underlying electrode. Chitosan possesses a unique combination properties meet these serve as effective bio-device...
Abstract Electron transfer in biology occurs with individual or pairs of electrons, and is often mediated by catechol/ o ‐quinone redox couples. Here, a biomimetic polysaccharide‐catecholic film fabricated two steps. First, the stimuli‐responsive polysaccharide chitosan electrodeposited as permeable film. Next, chitosan‐coated electrode immersed solution containing catechol biased to anodically‐oxidize catechol. The oxidation products covalently graft films evidenced electrochemical quartz...
Redox cycling provides a mechanism to amplify electrochemical signals for analyte detection. Previous studies have shown that diverse mediators/shuttles can engage in redox-cycling reactions with biobased redox capacitor is fabricated by grafting redox-active catechols onto chitosan film. Here, we report this catechol-chitosan detecting bacterial metabolite. Specifically, studied the metabolite pyocyanin reported be virulence factor and signaling molecule opportunistic pathogen P....
Two thin-film assembly methods are coupled to address proteins. Electrodeposition confers programmability and generates a template for layer-by-layer (LbL) assembly. LbL enables precise control of film thickness the incorporation labile biological components. The capabilities demonstrated using glucose oxidase (GOx) based electrochemical biosensing within microfabricated fluidic device.
Melanins are macromolecules that ubiquitous in nature and impart a large variety of biological functions, including structure, coloration, radiation resistance, free radical scavenging, thermoregulation. Currently, the majority investigations, melanins either chemically synthesized or extracted from animals, which presents significant challenges for large-scale production. Bacteria have been used as biocatalysts to synthesize biomaterials due their fast growth amenability genetic engineering...
Complex petroleum mass spectra obtained by Fourier-transform ion cyclotron resonance spectrometry (FTICR MS) were successfully interpreted at the molecular level applying principle component analysis (PCA) and hierarchical clustering (HCA). A total of 40 from 20 crude oil samples using both positive negative atmospheric pressure photoionization (APPI). Approximately 400 000 peaks identified level. Conventional data analyses would have been impractical with so much data. However, PCA grouped...
Abstract Electronic devices process information and transduce energy with electrons, while biology performs such operations ions chemicals. To establish bio‐device connectivity, we fabricate a redox‐capacitor film from polysaccharide (i.e., chitosan) redox‐active catechol. We report that these films are rapidly repeatedly charged discharged electrochemically via redox‐cycling mechanism in which mediators shuttle electrons between the electrode (capacitance ≈ 40 F/g or 2.9 mF/cm 2 ). Further,...
The electrodeposition of weak polyelectrolyte hydrogels involves an array subtle interactions. We report that salt dramatically affects the kinetics chitosan electrodeposition, and structure properties deposited hydrogel films. film growth was measured using a microfluidic device which demonstrated increases both rate extent deposition. by atomic force microscopy showed addition to deposition solution leads films with greater surface roughness (consistent tendency aggregate at high...
Macromolecular phenolics are among the most abundant organic molecules in nature, yet their biological activities largely unresolved because of structural complexity and an inability to probe functionality experimentally. We developed thin film electrochemical methodologies redox properties melanin, lignin, humic acid, three phenolic materials. observed that all matrixes possess activity can be repeatedly switched between oxidized reduced states. Furthermore, we melanin possesses pro-oxidant...
Abstract Pheomelanin has been implicated in the increased susceptibility to UV-induced melanoma for people with light skin and red hair. Recent studies identified a UV-independent pathway carcinogenesis pheomelanin’s pro-oxidant properties that act through generation of reactive oxygen species and/or depletion cellular antioxidants. Here, we applied an electrochemically-based reverse engineering methodology compare redox human hair pheomelanin model synthetic pigments natural eumelanin. This...
Melanins are ubiquitous in nature but their biological activities and functions have been difficult to discern. Conventional approaches determine material function start by resolving structure then characterize relevant properties. These less successful for melanins because of complex insolubility, properties not readily characterized conventional methods. Here, we report a novel spectroelectrochemical reverse engineering approach that focuses on redox radical scavenging activities. In this...
Oxidative stress is implicated in many diseases yet no simple, rapid, and robust measurement available at the point-of-care to assist clinicians detecting oxidative stress. Here, we report results from a discovery-based research approach which redox mediator used probe serum samples for chemical information relevant Specifically, use an iridium salt (K
A hydrogel-based dual film coating is electrofabricated for transducing bio-relevant chemical information into electronical output. The outer has a synthetic biology construct that recognizes an external molecular signal and transduces this input the expression of enzyme converts redox-inactive substrate redox-active intermediate, which detected through amplification mechanism inner redox-capacitor film.