A5100654455- Insect symbiosis and bacterial influences
- Invertebrate Immune Response Mechanisms
- Cell death mechanisms and regulation
- Carbon Nanotubes in Composites
- Immune Response and Inflammation
- Blood Coagulation and Thrombosis Mechanisms
- Quantum Chromodynamics and Particle Interactions
- High-Energy Particle Collisions Research
- Particle physics theoretical and experimental studies
- NF-κB Signaling Pathways
- Graphene research and applications
- Diamond and Carbon-based Materials Research
- Cerebral Venous Sinus Thrombosis
- Enzyme Production and Characterization
- Cancer-related gene regulation
- Metabolism, Diabetes, and Cancer
- Neurobiology and Insect Physiology Research
- Advanced Electron Microscopy Techniques and Applications
- Calpain Protease Function and Regulation
- Cell Adhesion Molecules Research
- Aquaculture disease management and microbiota
- Advanced X-ray Imaging Techniques
- Probiotics and Fermented Foods
- Infant Nutrition and Health
- Protein Hydrolysis and Bioactive Peptides
Seoul National University
2010-2025
Daegu Fatima Hospital
2025
Kyungpook National University
2015-2024
Ewha Womans University
1996-2024
Yonsei University
2024
Lawrence Livermore National Laboratory
2024
Samsung (South Korea)
2024
Korea Institute for Advanced Study
2024
Sungkyunkwan University
2021-2023
Great Western Hospital
2023
The symbiotic microbiota profoundly affect many aspects of host physiology; however, the molecular mechanisms underlying host-microbe cross-talk are largely unknown. Here, we show that pyrroloquinoline quinone-dependent alcohol dehydrogenase (PQQ-ADH) activity a commensal bacterium, Acetobacter pomorum, modulates insulin/insulin-like growth factor signaling (IIS) in Drosophila to regulate homeostatic programs controlling developmental rate, body size, energy metabolism, and intestinal stem...
We present results for the matrix elements of additional $\Delta S=2$ operators that appear in models physics beyond Standard Model (BSM), expressed terms four BSM $B$-parameters. Combined with experimental M_K$ and $\epsilon_K$, these constrain parameters models. use improved staggered fermions, valence HYP-smeared quarks $N_f=2+1$ flavors "asqtad" sea quarks. The configurations have been generated by MILC collaboration. matching between lattice continuum four-fermion bilinears is done...
Early-life malnutrition adversely affects nearly all organ systems, resulting in multiple physiological adaptations, including growth restriction and muscle bone loss. Although there is growing evidence that probiotics effectively improve systemic under malnourished conditions different animal models, our knowledge of the beneficial effects on various organs limited. Here, we show Lactobacillus plantarum strain WJL (LpWJL) can mitigate skeletal loss protein-malnourished juvenile mice. Mice...
Angiomyolipoma (AML), composed of smooth muscle cells, blood vessels, and adipose tissues, belongs to a family tumors originating from perivascular epithelioid cells. most commonly arises in the kidney but is extremely rare nasal cavity. classified into hepatorenal mucocutaneous AML. Mucocutaneous AML defined as skin nasopharyngeal mucosa. should be distinguished because has malignant potential. Moreover, must considered differential diagnosis for unilateral mass despite being disease. The...
While it is now accepted that the microbiome has strong impacts on animal growth promotion, exact mechanism remained elusive. Here we show microbiome-emitted scents contain volatile somatotrophic factors (VSFs), which promote host in an olfaction-independent manner Drosophila. We found inhaled VSFs are readily sensed by olfactory receptor 42b non-neuronally expressed subsets of tracheal airway cells, enteroendocrine and enterocytes. Olfaction-independent sensing activates airway-gut-brain...
In Drosophila melanogaster, although the NF-kappaB transcription factors play a pivotal role in inducible expression of innate immune genes, such as antimicrobial peptide exact regulatory mechanism tissue-specific constitutive these genes barrier epithelia is largely unknown. Here, we show that homeobox gene product Caudal functions modulator responsible for local peptides cecropin and drosomycin manner. These results suggest certain epithelial tissues have evolved unique strategy by...
BACKGROUND: Decoy receptor 3 (DcR3) is a soluble protein that binds to and inactivates the death ligand CD95L. Here, we studied possible association between DcR3 expression prognosis in patients with renal cell carcinomas (RCCs). METHODS: A tissue microarray containing RCC tumor samples corresponding normal was generated. tumors of 560 examined by immunohistochemistry. The effect on disease-specific survival progression-free assessed using univariate analysis multivariate Cox regression...
Excessive pro-inflammatory cytokine production from activated microglia contributes to neurodegenerative diseases, thus, microglial inactivation may delay the progress of neurodegeneration by attenuating neuroinflammation. Among 5 selected brown algae, we found highest antioxidant and anti-neuroinflammatory activities Myagropsis myagroides ethanolic extract (MME) in lipopolysaccharide (LPS)-stimulated BV-2 cells. The levels nitric oxide (NO), prostaglandin E2 (PGE2), cytokines were measured...
Abstract DcR3/TR6 is a secreted protein belonging to the TNFR family. It binds Fas ligand, LIGHT, and TL1A, all of which are TNF family members. LIGHT expressed on activated T cells. Its known receptors TR2 LTβR cell surface, TR6 in solution. In present study, we report soluble TR6-Fc or solid-phase costimulated proliferation, lymphokine production, cytotoxicity human cells presence TCR ligation. These costimulating effects were blocked by but not Fas-Fc. could also effectively costimulate...
We developed a fully closed nano-focus X-ray source using carbon nanotube (CNT) field emitters. The includes vacuum-sealed CNT Electron-gun (E-gun) tube and E-beam-focusing modules consisting of electrostatic magnetic lenses, facilitating very compact high-resolution imaging. paste-printed emitters were prepared in small pattern as an electron source, the entire components, including emitter module, Cu tubes, collimators, transmissive anode target, specially brazed at elevated temperature,...
Abstract Osteogenic transdifferentiation of vascular smooth muscle cells (VSMCs) is a risk factor associated with diseases. Wnt signaling one the major mechanisms implicated in osteogenic conversion VSMCs. Since Cdon has negative effect on distinct cellular processes, we sought to investigate role calcification. The expression was significantly downregulated VSMCs aortas patients atherosclerosis and aortic stenosis. Consistently, calcification models, including vitamin D3 (VD3)-injected mice...
Intranasal infection is commonly used to establish a SARS-CoV-2 mouse model due its non-invasive procedures and minimal effect from the operation itself. However, mice intranasally infected with have high mortality rate, which limits utility of this for exploring therapeutic strategies sequelae non-fatal COVID-19 cases. To resolve these limitations, an aerosolised viral administration method has been suggested. in-depth pathological analysis comparing two models lacking. Here, we show that...
We present a calculation of the kaon $B$-parameter, $B_K$, using lattice QCD. use improved staggered valence and sea fermions, latter generated by MILC collaboration with $N_f=2+1$ light flavors. To control discretization errors, we four different spacings ranging down to $a\approx 0.045\;$fm. The chiral continuum extrapolations are done SU(2) perturbation theory. Our final result is $\hat{B}_K = 0.727 \pm 0.004 (\text{stat}) 0.038 (\text{sys})$, where dominant systematic error from our...
Most human pancreatic cancer cells are resistant to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis. However, the mechanisms by which utilize their extracellular molecules counteract proapoptotic signaling mediated TNF family largely unknown. In this study, we demonstrate for first time that DcR3, a secreted decoy receptor malignant express at high level, acts as an antiapoptotic molecule binding TRAIL and counteracting its death-promoting function....
We present results for matrix elements of $\ensuremath{\Delta}S=2$ four-fermion operators arising generically in models new physics. These are needed to constrain such using the measured values ${\ensuremath{\epsilon}}_{K}$ and $\ensuremath{\Delta}{M}_{K}$. use lattice QCD with $2+1$ flavors improved staggered fermions on lattices generated by MILC Collaboration. extrapolate continuum from three spacings ranging down $a\ensuremath{\approx}0.045\text{ }\text{ }\mathrm{fm}$. Total errors...
The effects of fibroblast growth factors and their potential as broad-spectrum agents to treat mitigate radiation injury have been studied extensively over the past two decades. This report shows that a peptide mimetic basic factor (FGF-P) protects mitigates against acute syndromes. FGF-P attenuates both sepsis bleeding in radiation-induced bone marrow syndrome model reduces severity gastrointestinal cutaneous syndromes; it should also combined injuries. FGF-2 induce little or no deleterious...