A5067755392- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Cell Adhesion Molecules Research
- RNA Research and Splicing
- Neurogenetic and Muscular Disorders Research
- Mitochondrial Function and Pathology
- Cytokine Signaling Pathways and Interactions
- Caveolin-1 and cellular processes
- Asthma and respiratory diseases
- Gallbladder and Bile Duct Disorders
- HIV Research and Treatment
- Muscle Physiology and Disorders
- Allergic Rhinitis and Sensitization
- Pulmonary Hypertension Research and Treatments
- Cardiomyopathy and Myosin Studies
- Appendicitis Diagnosis and Management
- RNA regulation and disease
- Traumatic Brain Injury and Neurovascular Disturbances
- Adipose Tissue and Metabolism
- Intestinal Malrotation and Obstruction Disorders
- ATP Synthase and ATPases Research
- Whipple's Disease and Interleukins
- Sepsis Diagnosis and Treatment
- Electrolyte and hormonal disorders
- Pluripotent Stem Cells Research
Sejong University
2025
Institute of Aging
2024
Suwon Research Institute
2015-2023
Sungkyunkwan University
2015-2022
University of Ulsan
1997-2000
Asan Medical Center
1997-2000
Seoul National University
1996
Abstract Osteogenic transdifferentiation of vascular smooth muscle cells (VSMCs) is a risk factor associated with diseases. Wnt signaling one the major mechanisms implicated in osteogenic conversion VSMCs. Since Cdon has negative effect on distinct cellular processes, we sought to investigate role calcification. The expression was significantly downregulated VSMCs aortas patients atherosclerosis and aortic stenosis. Consistently, calcification models, including vitamin D3 (VD3)-injected mice...
Peroxisome proliferator–activated receptor-γ coactivator-1α (PGC-1α) is a master regulator of mitochondrial biogenesis. Reduced PGC-1α abundance linked to skeletal muscle weakness in aging or pathological conditions, such as neurodegenerative diseases and diabetes; thus, elevating might be promising strategy treat aging. Here, we performed high-throughput screening identified natural compound, farnesol, potent inducer PGC-1α. Farnesol administration enhanced oxidative capacity strength,...
Protein arginine methyltransferases (PRMTs) modulate diverse cellular processes, including stress responses. The present study explored the role of Prmt7 in protecting against menopause-associated cardiomyopathy. Mice with cardiac-specific ablation (cKO) exhibited sex-specific Male cKO mice impaired cardiac function, myocardial hypertrophy, and interstitial fibrosis associated increased oxidative stress. Interestingly, female predominantly comparable phenotypes only after menopause or...
Gastrointestinal involvement in Henoch-Schönlein syndrome: CT findings.Y K Jeong, H Ha, C Yoon, G Gong, P N Kim, M Lee, Y I Min and AuhAudio Available | Share
ABSTRACT Tumor suppressor p53 has been suggested to be a host restriction factor against HIV-1 replication, but the detailed molecular mechanism remained elusive for decades. Here, we demonstrate that p53-mediated suppression is attributed double-stranded RNA (dsRNA)-dependent protein kinase (PKR)-mediated trans -activator (Tat) phosphorylation and inactivation. silencing significantly enhanced replication in infected cells. Ectopic expression of suppressed Tat activity, which was rescued by...
Dab2 is an adapter protein involved in receptor-mediated signaling, endocytosis, cell adhesion, hematopoietic differentiation, and angiogenesis. It plays a pivotal role controlling cellular homeostasis. In the immune system, Foxp3 target gene required for regulatory T (Treg) function. expression its biological function dendritic cells (DCs) have not been described. this study, we found that was significantly induced during development of mouse bone marrow (BM)-derived DCs (BMDCs) human...
Endothelial dysfunction and senescence are pivotal in pulmonary diseases, including chronic obstructive disease (COPD). Protein arginine methyltransferase 1 (PRMT1) is the major enzyme responsible for asymmetric dimethylation plays a role diverse biological processes, cardiovascular function. Yet, its endothelial cells (ECs) remains poorly understood. Here, of PRMT1 investigated ECs, particularly context COPD pathogenesis. Endothelial-specific knockout mice exhibit hemorrhage, inflammation,...
Usefulness of CT in patients with ischemic colitis proximal to colonic cancer.G Y Ko, H K Ha, J Lee, Jeong, P N Kim, M G R S Yang and AuhAudio Available | Share
Dendritic cells (DCs) are the professional antigen-presenting that recognize and present antigens to naïve T induce antigen-specific adaptive immunity. Among T-cell subsets, helper type 2 (Th2) produce humoral immune responses required for protection against helminthic disease by activating B cells. DCs a Th2 response at certain environment. Basophil, eosinophil, mast cells, innate lymphoid also However, in case of DCs, controversy remains regarding which subsets immunity, genes...
The functional deterioration and loss of motor neurons are tightly associated with degenerative neuron diseases aging-related muscle wasting. Motor or wasting in turn contribute to increased risk adverse health outcomes the elderly. Cdon (cell adhesion molecule-downregulated oncogene) belongs immunoglobulin superfamily cell molecule plays essential roles multiple signalling pathways, including sonic hedgehog (Shh), netrin, cadherin-mediated signalling. as a Shh coreceptor critical role...
PURPOSE: To evaluate the clinical and radiologic features of biliary stricture after blunt abdominal trauma to report results endoscopic stent placement. MATERIALS AND METHODS: Medical records findings were reviewed in five patients with trauma. The level, length, contour strictures analyzed retrograde cholangiopancreatography (ERCP). Computed tomographic (CT) scans also determine presence dilatation, configuration injured bile duct, ancillary findings. Results from placement evaluated all...
PURPOSE: To evaluate use of triphasic helical computed tomography (CT) for early diagnosis occlusion and assessment ischemia in cases acute middle cerebral arterial occlusion. MATERIALS AND METHODS: Thirty-five patients with underwent CT within 6 hours after symptom onset. Early arterial, perfusion, delayed phase scans were obtained 18, 30, 80 seconds, respectively, contrast material administration. Eighteen had proximal diagnosed at magnetic resonance (MR) or digital subtraction...
ERCP and CT findings of ectopic drainage the common bile duct into duodenal bulb.H J Lee, H K Ha, M Kim, Y Jeong, P N G S D Suh, I Min AuhAudio Available | Share
During muscle regeneration, interferon-gamma (IFN-
Doppler sonographic findings were correlated with symptoms and intravenous urographic in 31 patients unilateral renal obstruction 30 control subjects. No significant correlation was found between resistive index symptom duration or pelvicalyceal opacification time on urography. With a cutoff of 0.7, the sensitivity 19.3% diagnosing obstruction; however, it 80% subgroup acute severely delayed time. sonography has very low obstruction, but may be useful when is severe.
Background of the present study was to assess usefulness double phase positron emission tomography/computed tomography (PET/CT) differentiate malignant from benign pulmonary lesions with low fluorine-18 fluorodeoxyglucose (F-18 FDG) uptake. Of 218 consecutive patients who underwent F-18 FDG PET/CT evaluate found on CT, we retrospectively analyzed 30 had focal an SUV <2.5. All thorax at two time points: scan 1 60 min and 2 120 after intravenous injection 2.5 MBq FDG. The images were visually...
The Src homology 2 domain-containing adaptor protein B (SHB) is widely expressed in immune cells and acts as an important regulator for hematopoietic cell function. SHB silencing induces Th2 immunity mice. also involved T-cell homeostasis vivo. However, has not yet been studied addressed association with dendritic (DCs). effects of expression on the immunogenicity DCs were assessed by Shb gene mouse bone marrow-derived (BMDCs). After silencing, surface phenotype, cytokine profile,...
Endothelial cells (ECs) play vital roles in regulation of vascular homeostasis, tone, leukocyte traffcking, and barrier function to ensure pulmonary function. dysfunction is a key factor for the progression pathogenesis. Protein arginine methyltransferase 1 (Prmt1) catalyzes asymmetric di-methylation substrates on residues implicated variety cellular processes, including cardiovascular In current study, we examined role Prmt1 endothelial by using tamoxifen-inducible EC-specific ablation (KO)...
<title>Abstract</title> Activating transcription factor 3 (ATF3) is a critical regulator for cellular stress responses and implicated in stress-induced cardiac hypertrophy fibrosis. However, the role of ATF3 cardiomyopathy remains controversial. Here, we demonstrate that plays cardioprotective by controlling mitochondrial oxidative angiotensin II (Ang II)-triggered cardiomyopathy. The expression was significantly upregulated hypertrophic hearts chronically infused with Ang II, which...