A5063774012- Plant Pathogens and Fungal Diseases
- Mycorrhizal Fungi and Plant Interactions
- Fungal Biology and Applications
- Cell death mechanisms and regulation
- Fungal and yeast genetics research
- French Urban and Social Studies
- Insect symbiosis and bacterial influences
- Invertebrate Immune Response Mechanisms
- Social Sciences and Governance
- Plant Reproductive Biology
- Fermentation and Sensory Analysis
- Neurobiology and Insect Physiology Research
- Entomopathogenic Microorganisms in Pest Control
- Enzyme-mediated dye degradation
- Insect Resistance and Genetics
- Education, sociology, and vocational training
- Plant-Microbe Interactions and Immunity
- Neurological diseases and metabolism
- Phagocytosis and Immune Regulation
- Protist diversity and phylogeny
- NF-κB Signaling Pathways
- Mitochondrial Function and Pathology
- Biofuel production and bioconversion
- Philosophy, Sociology, Political Theory
- Prion Diseases and Protein Misfolding
Laboratoire Interdisciplinaire des Énergies de Demain
2013-2023
Université Paris Cité
2008-2023
Centre National de la Recherche Scientifique
2000-2022
Institut Jacques Monod
2022
Université Paris-Sud
2012-2016
Sorbonne Paris Cité
2012-2014
Expression Génétique Microbienne
2012-2013
Délégation Paris 7
2009-2012
Institut de Recherches en Technologies et Sciences pour le Vivant
2008
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2008
Summary NADPH oxidases are enzymes that produce reactive oxygen species. Studies in mammals, plants and fungi have shown they play important roles differentiation, defence, host/pathogen interaction mutualistic symbiosis. In this paper, we identified a Podospora anserina mutant strain impaired for processes controlled by PaNox1 PaNox2, the two Nox isoforms characterized model ascomycete. We show gene mutated is PaNoxR , homologue of encoding regulatory subunit p67 phox conserved mammals...
High-mobility group (HMG) B proteins are eukaryotic DNA-binding characterized by the HMG-box functional motif. These transcription factors play a pivotal role in global genomic functions and control of genes involved specific developmental or metabolic pathways. The filamentous ascomycete Podospora anserina contains 12 genes. Of these, four have been previously characterized; three mating-type that fertilization development fruit-body, whereas last one encodes factor mitochondrial DNA...
Septic injury triggers a rapid and widespread response in Drosophila adults that involves the up‐regulation of many genes required to combat infection for wound healing. Genome‐wide expression profiling has already demonstrated this is controlled by signaling through Toll, Imd, JAK‐STAT JNK pathways. Using oligonucleotide microarrays, we now demonstrate MAPKKK Mekk1 regulates small subset induced septic including Turandot ( Tot ) stress genes. Our analysis indicates show complex regulation...
Summary NADPH oxidases ( N ox) are membrane complexes that produce O 2 − . Researches in mammals, plants and fungi highlight the involvement of Nox‐generated ROS cell proliferation, differentiation defense. I n core enzyme gp91 phox / ox2 is associated with p22 forming flavocytochrome b 558 ready for activation by a cytosolic complex. Intriguingly, no homologue gene has been found fungal genomes, questioning how flavoenzyme forms. Using whole genome sequencing combined phylogenetic analysis...
Insects are well known vectors of human and animal pathogens millions people killed by mosquito-borne diseases every year. The use insecticides to target insect has been hampered the issues toxicity environment selection resistant insects. Therefore, biocontrol strategies based on naturally occurring microbial emerged as a promising control alternative. entomopathogenic fungus Beauveria bassiana is characterized have approved United States Environmental Protection Agency pest biological...
Phytopathogenic and mycorrhizal fungi often penetrate living hosts by using appressoria related structures. The differentiation of similar structures in saprotrophic to dead plant biomass has seldom been investigated reported only the model fungus Podospora anserina. Here, we report on ability many saprotrophs from a large range taxa produce cellophane. Most Ascomycota Basidiomycota were able form appressoria. In contrast, none three Mucoromycotina was differentiate such filamentous no...
The Podospora anserina PaMpk1 MAP kinase (MAPK) signaling pathway can generate a cytoplasmic and infectious element resembling prions. When present in the cells, this C causes crippled growth (CG) cell degeneration. CG results from inappropriate autocatalytic activation of MAPK during growth, whereas cascade normally signals stationary phase. Little is known about control such prion-like hereditary units involved regulatory inheritance. Here, we show that another pathway, PaMpk2, crucial at...
Higher fungi, which comprise ascomycetes and basidiomycetes, play major roles in the biosphere. Their evolutionary success may be due to extended dikaryotic stage of their life cycle, is basis for scientific name: Dikarya. Dikaryosis maintained by similar structures, clamp basidiomycetes crozier ascomycetes. Homeodomain transcription factors are required formation all studied. We identified homeobox genes filamentous ascomycete fungus Podospora anserina constructed deletion mutants each...
Convergent evolution of trophic life style and morphological characters are very common in the fungal kingdom. Recently, we have shown that same molecular machinery containing a tetraspanin NADPH oxidase has been recruited two different species for purpose (exiting from melanized re-enforced cell at focal weakened point), but stages their development (ascospore germination appressorium mediated penetration). Although this is required these key developmental steps, it also likely involved...
Abstract Sexual reproduction in Ascomycetes is well described several model organisms such as Neurospora crassa or Podospora anserina . Deciphering the biological process of sexual (from recognition between compatible partners to formation zygote) can be a major advantage better control sexually reproducing pathogenic fungi. In Pyricularia oryzae , fungal pathogen causing blast diseases on Poaceae species, biology remains poorly documented. Besides well‐documented production asexual...
Trichosporonosis is a rare invasive infection in humans mainly due to Trichosporon asahii, and especially recovered from patients having haematological malignancy. Since 2012, IGS1 region sequencing used as genotyping method distinguish isolates, with high frequency of one haplotype worldwide geographic specificity for some haplotypes.We compared the whole genome (WGS) study relationship between clinical isolates involved two grouped cases France.IGS1 antifungal susceptibility testing were...
Sexual reproduction is a key process influencing the evolution and adaptation of animals, plants, many eukaryotic microorganisms, such as fungi. However, sequential cell biology fertilization associated nuclear dynamics after plasmogamy are poorly understood in filamentous Using histone-fluorescent parental isolates, we tracked male female nuclei during model ascomycete Neurospora crassa using live-cell imaging. This study unravels behavior trichogyne resident extraordinary manner which...