A5091748244- Fungal and yeast genetics research
- Peroxisome Proliferator-Activated Receptors
- Mitochondrial Function and Pathology
- Photosynthetic Processes and Mechanisms
- Plant and fungal interactions
- Plant Reproductive Biology
- Plant-Microbe Interactions and Immunity
- Mycorrhizal Fungi and Plant Interactions
- Fungal Biology and Applications
- DNA Repair Mechanisms
- 14-3-3 protein interactions
- Plant Pathogens and Fungal Diseases
- Cellular transport and secretion
- Yeasts and Rust Fungi Studies
- Ubiquitin and proteasome pathways
- Protist diversity and phylogeny
- Microtubule and mitosis dynamics
- Biofuel production and bioconversion
- Signaling Pathways in Disease
- Algal biology and biofuel production
- Plant biochemistry and biosynthesis
- Microbial Metabolites in Food Biotechnology
- Steroid Chemistry and Biochemistry
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Marine Toxins and Detection Methods
Universidad Nacional Autónoma de México
2002-2024
Université Paris-Sud
2008-2014
Centre National de la Recherche Scientifique
2008-2014
Expression Génétique Microbienne
2013
Columbia University
2010-2012
High-mobility group (HMG) B proteins are eukaryotic DNA-binding characterized by the HMG-box functional motif. These transcription factors play a pivotal role in global genomic functions and control of genes involved specific developmental or metabolic pathways. The filamentous ascomycete Podospora anserina contains 12 genes. Of these, four have been previously characterized; three mating-type that fertilization development fruit-body, whereas last one encodes factor mitochondrial DNA...
Peroxisome biogenesis relies on two known peroxisome matrix protein import pathways that are mediated by the receptors PEX5 and PEX7. These converge at importomer, a peroxisome-membrane complex is required for translocation into peroxisomes consists of docking RING-finger subcomplexes. In fungus Podospora anserina, peroxins crucial meiocyte formation, while PEX5, PEX7 or peroxin PEX14 not. Here we show PEX14-related PEX14/17 differentially involved in during development. activity does not...
The Chk2-mediated deoxyribonucleic acid (DNA) damage checkpoint pathway is important for mitochondrial DNA (mtDNA) maintenance. We show in this paper that mtDNA itself affects cell cycle progression. Saccharomyces cerevisiae rho0 cells, which lack mtDNA, were defective G1- to S-phase Deletion of subunit Va cytochrome c oxidase, inhibition F1F0 adenosine triphosphatase, or replacement all mtDNA-encoded genes with noncoding did not affect Thus, the progression defect cells caused by loss...
Fungal pellets are hierarchical systems that can be found in an ample variety of applications. Modeling transport phenomena this type is a challenging but necessary task to provide knowledge-based processes improve the outcome their biotechnological In work, upscaled model for total mass and momentum fungal implemented analyzed, using elements volume averaging adjoint homogenization methods departing from governing equations at microscale intracellular extracellular phases. The biomass...
Peroxisomes are involved in a variety of metabolic pathways and developmental processes. In the filamentous fungus Podospora anserina , absence different peroxins implicated peroxisome matrix protein import leads to defects. Lack RING‐finger complex peroxin PEX2 blocks sexual development at dikaryotic stage, while both receptors, PEX5 PEX7, karyogamy meiosis can proceed spores formed. This suggests role for that prompted us study involvement complex. We show that, like PEX2, two other...
The NADPH oxidases (NOX) catalyze the production of superoxide by transferring electrons from to O2, in a regulated manner. In Neurospora crassa NOX-1 is required for normal growth hyphae, development aerial mycelium and asexual spores, it essential sexual differentiation cell-cell fusion. Determining subcellular localization critical step understanding mechanisms which this enzyme can regulate all these different processes. Using fully functional versions tagged with mCherry, we show that...
Peroxisomes are versatile and dynamic organelles that required for the development of diverse eukaryotic organisms. We demonstrated previously in fungus Podospora anserina different peroxisomal functions at distinct stages sexual development, including initiation progression meiocyte (ascus) differentiation germination spores (ascospores). Peroxisome assembly during these processes relies on differential activity protein machinery drives import proteins into organelle, indicating a complex...
The filamentous fungus Podospora anserina has been used as a model organism for more than 100 years and proved to be an invaluable resource in numerous areas of research. Throughout this period, P. embroiled number taxonomic controversies regarding the proper name under which it should called. most recent treatment proposed change important species Triangularia . results past changes indicate that broader research community is unlikely accept change, will lead nomenclatural instability...
Mitochondria and peroxisomes are organelles whose activity is intimately associated that play fundamental roles in development. In the model fungus Podospora anserina, mitochondria required for different stages of sexual development, evidence indicates their this process interrelated. Additionally, development involves precise regulation peroxisome assembly dynamics. Peroxisomes share proteins mediating division. The dynamin-related protein Dnm1 (Drp1) along with its membrane receptors, like...
The endoplasmic reticulum (ER) is an elaborate organelle composed of distinct structural and functional domains. ER structure dynamics involve membrane-shaping proteins the reticulon Yop1/DP1 families, which promote membrane curvature regulate shaping remodeling. Here, we analyzed function (RTN1) Yop1 (YOP1 YOP2) model fungus Podospora anserina their contribution to sexual development. We found that RTN1 YOP2 localize peripheral are enriched in dynamic apical domains polarized growing hyphal...
Sexual reproduction allows eukaryotic organisms to produce genetically diverse progeny. This process relies on meiosis, a reductional division that enables ploidy maintenance and genetic recombination. Meiotic differentiation also involves the renewal of cell functioning promote offspring rejuvenation. Research in model fungus
Eukaryotic cell development involves precise regulation of organelle activity and dynamics, which adapt the architecture metabolism to changing developmental requirements. Research in various fungal model organisms has disclosed that meiotic spatiotemporal formation dynamics distinct intracellular membrane compartments, including peroxisomes, mitochondria domains endoplasmic reticulum, comprising its peripheral nuclear envelope. This implicates changes constitution these organelles, modulate...