A5101861762- Plant-Microbe Interactions and Immunity
- Food Quality and Safety Studies
- Gut microbiota and health
- Plant Pathogens and Fungal Diseases
- Metabolomics and Mass Spectrometry Studies
- Ginseng Biological Effects and Applications
- Nutrition, Health and Food Behavior
- Plant tissue culture and regeneration
- Microbial Natural Products and Biosynthesis
- Probiotics and Fermented Foods
- Phytoestrogen effects and research
- Essential Oils and Antimicrobial Activity
- Antibiotic Resistance in Bacteria
- Natural product bioactivities and synthesis
- Plant Pathogenic Bacteria Studies
- Bacterial biofilms and quorum sensing
- Sodium Intake and Health
- Plant Disease Resistance and Genetics
- Cell death mechanisms and regulation
- Plant Virus Research Studies
- Antimicrobial Peptides and Activities
- Angiogenesis and VEGF in Cancer
- Healthcare Education and Workforce Issues
- Fungal Biology and Applications
- Cancer, Hypoxia, and Metabolism
Gyeongsang National University
2017-2024
Korea University of Science and Technology
2019-2024
Korea Research Institute of Chemical Technology
2020-2024
Hannam University
2024
Yonsei University
2024
Yuhan (South Korea)
2024
Inha University
2024
Korea Research Institute of Bioscience and Biotechnology
2008-2022
Ewha Womans University
2021
Daewoong Pharmaceutical (South Korea)
2020
Abstract To address the drug-resistance of bacterial pathogens without imposing a selective survival pressure, virulence and biofilms are highly attractive targets. Here, we show that terrein, which was isolated from Aspergillus terreus , reduced factors (elastase, pyocyanin, rhamnolipid) biofilm formation via antagonizing quorum sensing (QS) receptors affecting Pseudomonas aeruginosa cell growth. Additionally, effects terrein on production QS signaling molecules expression QS-related genes...
Ginsenoside Rg3, one of the major ingredients heat-processed ginseng, has been reported to inhibit growth various cancer cells.We previously that Rg3 inhibited proliferation and induced apoptosis breast (MDA-MB-231) cells.In present study, we have explored mechanism underlying anti-proliferative proapoptotic effects in MDA-MB-231 cells, which constitutively activated NF-κB mutant form p53.Rg3 DNA binding transcriptional activity these were attributable its suppression IKKβ activity,...
Rg3, a major ginsenoside derived from heat-processed ginseng, has been reported to have anti-inflammatory and anti-proliferative activities. In our previous studies, Rg3 inhibited phorbol ester-induced cyclooxygenase-2 expression NF-κB activation in cultured human mammary epithelial (MCF-10A) cells mouse skin vivo. this study, we investigated Rg3-induced apoptosis breast cancer (MDA-MB-231) underlying molecular mechanisms.After treatment, apoptotic cell death of MDA-MB-231 was by the MTT...
The effects of purified salt (PS) and mineral-rich sea (MRS), both with different mineral profiles, on kimchi fermentation were studied using a culture-dependent 16S rRNA sequencing technique mass-based metabolomic analysis. profiles in the medium caused changes bacterial 2 products. An increase Leuconostoc species MRS-kimchi decreased Lactobacillus/Leuconostoc ratio, which led to metabolites (including sugars, amino acids, organic lipids, sulfur compounds, terpenoids) associated quality....
Abstract BACKGROUND Increased soil salt concentration decreases productivity and changes the physiological chemical properties of plants. Various omics technologies have been used to understand response in plants but overall metabolite profiles spinach ( Spinacia oleracea L.) under stress not studied. In this article, therefore, mineral cultivated with different NaCl concentrations 0–200 mmol L –1 irrigation water were analyzed investigate effect on nutritional quality. RESULTS Increasing...
The gut microbiome is related to various host health conditions through metabolites produced by microbiota. Investigating their relationships involves association analysis of the population-level and metabolome data, which requires appropriate collection, handling, storage specimens. Simplification specimen handling processes will facilitate such investigations. As a pilot study for studies, we collected fecal samples from three volunteers tested whether single sample collection procedure,...
In the pathosystems of Turnip mosaic virus (TuMV) with Brassicaceae crops, various symptoms, including and necrosis, are observed. We previously reported a necrosis-inducing factor TuNI in Arabidopsis thaliana, model species. this study, we show that necrotic symptom induced by TuNI, observed along veins, was actually form defense response accompanying hypersensitive reaction (HR)-like cell death veinal area. The is often localized region. associated production H2O2, accumulation salicylic...
Microbial metabolites have been recognized as an important source for the discovery of new antifungal agents because their diverse chemical structures with novel modes action. In course our screening from microbes, we found that culture filtrates two fungal species Aspergillus candidus SFC20200425-M11 and montenegroi SFC20200425-M27 potentials to reduce development plant diseases such tomato late blight wheat leaf rust. From these spp., isolated a total seven active compounds, including...
Virulence factors and biofilms constitute attractive targets for the prevention of infections caused by multidrug-resistant bacteria. Among alkyl gallates, propyl gallate (PG) octyl (OG) are used as food preservatives. Here we found that gallates differentially affect virulence, biofilm formation, quorum sensing (QS) in Pseudomonas aeruginosa. Ethyl (EG), PG, butyl (BG) inhibited formation virulence including elastase, pyocyanin, rhamnolipid, P. aeruginosa without affecting cell viability...
Abstract Efficient use of nutrients is a key requisite for sustainable intensification agriculture in order to meet the increasing global crop demand while minimizing deleterious environmental impacts. Agroforestry systems exhibit tree–crop interactions, which potentially contribute nutrient-efficient agro-ecosystems. Our goal was determine whether conversion from cropland monocultures alley-cropping agroforestry increases nutrient response efficiency (NRE), ability plants convert available...
Bacterial contamination of food-contact surfaces can be a potential risk factor for food quality and safety. To evaluate the spatial temporal variations cross-contamination routes, we conducted biogeographical assessment bacteria in foodservice facility based on diversity microflora each surface. this end, performed high-throughput amplicon sequencing 13 non-food contact throughout year. The results showed that Bacillus , Acinetobacter, Streptophyta Enterobacter Pseudomonas Serratia...
Plant pathogenic fungi cause serious diseases, which result in the loss of crop yields and reduce quality crops worldwide. To counteract escalating risks chemical fungicides, interest biological control agents to manage plant diseases has significantly increased. In this study, we comprehensively screened microbial culture filtrates using a yeast screening system find microbes exhibiting respiratory inhibition activity. Consequently, found soil-borne microbe Brevibacillus brevis HK544 strain...
Acute lung injury (ALI) is characterized by alveolar damage, edema, and exacerbated inflammatory response. Growth arrest-specific protein 6 (Gas6) mediates many different functions, including cell survival, proliferation, signaling, apoptotic clearance (efferocytosis). The role of Gas6 in bleomycin (BLM)-induced ALI unknown. We investigated whether exogenous administration mouse recombinant (rGas6) has anti-inflammatory anti-apoptotic effects on BLM-induced ALI. Compared to mice treated with...
Seven new coralmycin derivatives, coralmycins C (1), D (2), E (3), F (4), G (5), H (6), and I (7), along with three known compounds, cystobactamids 891-2 (8), 905-2 (9), 507 (10), were isolated from a large-scale culture of the myxobacteria Corallococcus coralloides M23. The structures these including their relative stereochemistries, elucidated by interpretation spectroscopic CD data. structure-activity relationships antibacterial DNA gyrase inhibitory activities indicated that...
In this paper, a new concept for an anion sensor is demonstrated. We synthesized anion-responsive N-allyl-N′-ethylurea (AEU) that can form hydrogen-bonded complexes with various anions. An allyl functional group enables AEU to participate in copolymerization hydroxyethyl methacrylate (HEMA) and crosslinker crosslinked gel. Photopolymerization of the mixed monomer was conducted presence polymeric opal template, subsequent removal template resulted blue-colored photonic gel organic solvents...
Although bevacizumab (Avastin®) has been approved as an antiangiogenic agent against some cancers, the efficacy is transient and unsatisfactory in other cancers most likely owing to presence of alternative proangiogenic factors. Therefore, simultaneous blocking several factors may be a promising strategy for cancer therapeutics. Accordingly, neuropilin-1 (NRP1) attractive target because it serves multifunctional receptor vascular endothelial growth factor (VEGF) family. Here, we aimed...
Ginseng consumption has been shown to prevent and reduce many health risks, including cardiovascular disease. However, the ginseng-induced changes in biofluids tissue metabolomes associated with blood remain poorly understood. In this study, healthy rats were orally administered ginseng extracts or water for one month. Biofluid metabolites along steroid hormones, plasma cytokines, pressure factors determined elucidate relationship between intake vessel health. Moreover, effect of extract on...
In the present report, effects of blanching, steaming, and high temperature/high pressure processing (HTHP) on amino acid contents commonly consumed Korean root vegetables, leaf pulses were evaluated using an Automatic Amino Acid Analyzer. The total content samples tested was between 3.38 g/100 g dry weight (DW) 21.32 DW in raw vegetables 29.36 30.55 pulses. With HTHP, we observed significant decreases lysine arginine lysine, arginine, cysteine Moreover, blanched steamed more similar than...
Plant-derived compounds have been historically used for the treatment of various diseases and an important source several clinically useful anti-cancer agents. The Artemisia annua is known as a medicinal herb that effective against cancer. Thus, purpose this study was to investigate whether ethanol extracts could increase effect LS174T cells. Our results show (AAE) induces apoptosis through regulation mitochondria outer membrane potential. We demonstrate induced by p53-dependent manner when...
The necrotrophic fungus Botrytis cinerea releases extracellular enzymes that facilitate its penetration into a host. This study functionally characterized the gene pdeR of B. cinerea, which is predicted to encode Zn(II)2Cys6 zinc finger transcription factor. To investigate role pdeR, deleted and complemented strains in were generated, designated as ΔpdeR PdeRc, respectively. strain exhibited impaired germination growth compared wild-type PdeRc strains, particularly when provided with maltose...
Menthol has a considerable cooling effect, but the use range of menthol is limited because its extremely low solubility in water and inherent flavor. (-)-Menthol β-glucoside was determined to be more soluble (>27 times) than (-)-menthol α-glucoside; hence, β-anomer-selective glucosylation necessary. The vitro glycosylation by uridine diphosphate glycosyltransferase (BLC) from Bacillus licheniformis generated new β-galactoside N-acetylglucosamine. maximum conversion rate β-D-glucoside BLC...