A5101878335- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Radiomics and Machine Learning in Medical Imaging
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- RNA Research and Splicing
- Phytochemistry and Biological Activities
- Head and Neck Cancer Studies
- Ferroptosis and cancer prognosis
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Cell Adhesion Molecules Research
- Single-cell and spatial transcriptomics
- Lung Cancer Research Studies
- Esophageal Cancer Research and Treatment
- Sesquiterpenes and Asteraceae Studies
- Peptidase Inhibition and Analysis
- Gastric Cancer Management and Outcomes
- Natural product bioactivities and synthesis
- Monoclonal and Polyclonal Antibodies Research
Capital Medical University
2022-2023
Beijing Chest Hospital
2022-2023
Peking University People's Hospital
2018-2021
Peking University
2018-2021
Shanghai Chest Hospital
2016-2017
Lanzhou University
1999
Lung adenocarcinoma manifesting as radiological subsolid nodules has distinct cell composition within its tumor microenvironment.
Abstract Studies have demonstrated that noncoding RNAs play important roles in various types of cancer; however, derived from regions genomic alterations rarely been explored, especially for circular (circRNA). Previously, we found several circRNAs were upregulated lung adenocarcinoma (LUAD) tumor tissues by RNA sequencing. Here, characterized a novel circRNA, circXPO1, LUAD, which is well-established cancer therapeutic target, XPO1. formed back-splicing exon 3 and 4 XPO1 gene. circXPO1 was...
It is still debatable whether complete mediastinal lymph node dissection (MLND) associated with better survival than sampling (MLNS) in surgical treatment of nonsmall cell lung cancer (NSCLC). We aimed to assess the impact on long-term among stage I NSCLC patients. In this cohort study, 317 Chinese patients Shanghai Chest Hospital were followed up for at least 10 years evaluate different modes their survival. Among them, 161 MLND group and 156 MLNS group. Overall median times calculated 2...
Abstract Background Emerging evidence indicates that circular RNAs (circRNAs) play vital roles in tumor progression, including lung adenocarcinomas (LUAD). However, the mechanisms by which circRNAs promote progression of LUAD still require further investigation. Methods Quantitative real-time PCR was performed to detect expression circP4HB tissues and cells. Then, Kaplan–Meier analysis used determine prognostic value expression. We employed RNA pull-down, immunoprecipitation, mass...
Abstract Purpose Accumulating evidence has highlighted the critical roles of circular RNAs (circRNAs) in non‐small‐cell lung cancer (NSCLC). This study aims to unveil circRARS (circular RARS) (hsa_circ_0001551) NSCLC. Methods Quantitative real‐time PCR was used determine expression NSCLC tissues and cells. Kaplan–Meier analysis prognostic value expression. CCK8, transwell, wound healing assays were assess proliferation, invasion, migration abilities RNA pull‐down, cell fraction, glucose...
Collagen type VI alpha 6 chain ( COL6A6 ), a novel collagen, has been considered as tumor suppressor and therapeutic target in several tumors. However, the functional role of immune cell infiltration prognostic value lung adenocarcinoma (LUAD) remains unknown. Here, we evaluated expression its impact on survival among LUAD patients from The Cancer Genome Atlas (TCGA) other databases. was downregulated tissues compared to normal at both mRNA protein levels. negatively associated with...
Synchronous multiple primary lung cancer (sMPLC) is a sparse disease in the past, but there has been gradual increase morbidity of sMPLC recently. However, studies on large sample have never undertaken. The purpose this study to investigate diagnosis, treatment and prognosis through analyzing clinical data, provide supports for management sMPLC.According Martini-Melamed criteria, 357 patients were diagnosed sMPLC. pathological staging basis 8th edition tumor-node-metastasis (TNM) from...
The aim of this study was to investigate the allelic relation between de novo T790M and concomitant sensitizing EGFR mutations in EGFR-TKIs naïve NSCLCs explore whether formalin-fixed paraffin-embedded (FFPE) materials affect detection mutation.Specimens 300 consecutive EGFR-TKI who received surgical resection January 2016 June 2018 were retrospectively investigated. All snap-frozen tumor tissues from screened by droplet digital PCR (ddPCR) for mutation. mutation also Furthermore, we...
Circulating-free RNAs (cfRNAs) have been regarded as potential biomarkers for "liquid biopsy" in cancers. However, the circulating messenger RNA (mRNA) and long noncoding (lncRNA) profiles of lung cancer not fully characterized. In this study, we profiled mRNA lncRNA 16 patients 4 with benign pulmonary nodules. Compared nodules, 806 mRNAs 1,762 lncRNAs were differentially expressed plasma adenocarcinoma patients. For squamous cell carcinomas, 256 946 expressed. A total 231 298 small cancer....
Background Nonsynonymous tumor mutation burden (NSTMB) could affect the prognosis of esophageal cancer (EC) patients, but differentially expressed genes between EC patients with different NSTMB have not been explored. Our study aimed to compare (high vs. low). Methods RNA‐seq data for were downloaded from The Cancer Genome Atlas (TCGA). edgeR package was used identify NSTMB. Cell type identification by estimating relative subsets known RNA transcripts (CIBERSORT) software employed underscore...
Abstract Background This study was aimed to investigate the allelic relation between de novo T790M and concomitant sensitizing EGFR mutations in EGFR-TKIs naïve NSCLCs explore whether formalin-fixed paraffin-embedded (FFPE) materials affect detection of mutation. Methods 300 consecutive EGFR-TKI who received surgical resection January 2016 June 2018 retrospectively investigated. All snap-frozen tumor tissues from were screened by droplet digital PCR (ddPCR) for The mutation also Furthermore,...
Abstract A novel procedure for introduction of a-methoxy-methyl butenolide and butadienolide structures to the eudesmanolide have been developed, which is convenient synthetically valuable natural sesquiterpenoids containing moieties above.