A5067126102- Parasitic infections in humans and animals
- Parasitic Infections and Diagnostics
- Congenital Anomalies and Fetal Surgery
- Amoebic Infections and Treatments
- Parasite Biology and Host Interactions
- Chemokine receptors and signaling
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Immunotherapy and Immune Responses
- Animal Genetics and Reproduction
- Tissue Engineering and Regenerative Medicine
- Telomeres, Telomerase, and Senescence
- Cancer Research and Treatments
- Advanced biosensing and bioanalysis techniques
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ovarian cancer diagnosis and treatment
- T-cell and B-cell Immunology
- Cytokine Signaling Pathways and Interactions
- Endoplasmic Reticulum Stress and Disease
- Kruppel-like factors research
- Liver Disease Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Endometrial and Cervical Cancer Treatments
- Mast cells and histamine
First Affiliated Hospital of Xinjiang Medical University
2015-2024
Xinjiang Medical University
2015-2024
Beijing Institute of Technology
2023
Tianjin Fire Research Institute
2023
Tianjin Third Central Hospital
2013-2022
Tianjin Medical University
2013-2022
Tianjin University
2020
Nankai University
2020
Xinjiang Agricultural University
2008
Air Force Medical University
2004-2007
Background and Aims: As the predominant lymphocyte subset in liver, natural killer (NK) cells have been shown to be highly associated with outcomes of patients chronic hepatitis B virus infection (CHB) hepatocellular carcinoma (HCC). Previously, we reported that NKG2A, a checkpoint candidate, mediates human murine NK cell dysfunction CHB. However, exhaustion and, particularly, level NKG2A expression within liver tumors not reported.Methods: In this study, analyzed related located intra- or...
Background: Control of ER-mitochondrial Ca 2+ fluxes is a critical checkpoint to determine cell fate under stress.The 75-kDa glucose-regulated protein (GRP75) key tether facilitating mitochondria-associated ER membrane (MAM) formation through the IP3R-GRP75-VDAC1 complex.Although GRP75 contributes cisplatin (CP)-resistance ovarian cancer (OC), underlying mechanisms are not clear.Methods: CP-resistant and -sensitive OC lines with stable modulation were established.Confocal, PLA, co-IP, TEM...
The cestode Echinococcus multilocularis infection, a serious health problem worldwide, causes alveolar echinococcosis (AE), tumor-like disease predominantly located in the liver and able to spread any organs. Until now, there have been few studies that explore how T-cell exhaustion contributes parasite's escape from immune attack it might be reversed.In this study, we found immunoreceptor with immunoglobulin tyrosine-based inhibitory motif domain (TIGIT) expression was significantly enhanced...
Alveolar echinococcosis (AE) is characterized by the development of irreversible fibrosis and immune tolerance towards Echinococcus multilocularis (E. multilocularis). Very little known on presence transforming growth factor-β (TGF-β) other components TGF-β/Smad pathway in liver, their possible influence fibrosis, over various stages infection. Using Western Blot, qRT-PCR immunohistochemistry, we measured levels TGF-β1, TGF-β receptors, down-stream Smads activation, as well marker expression...
The local immune mechanisms responsible for either self-healing or sustained chronic infection are not clear, in the development of E. multilocularis larvae. Here, we developed a suitable experimental model that mimics naturally infected livers, according to parasite load. We demonstrated cellular immunity and fibrogenesis actually protective fully able limit metacestode growth liver low medium dose-infected mice (LDG MDG), even clear it, while impairment is followed by more rapid severe...
Background and Aims Alveolar echinococcosis (AE) is a lethal helminthic liver disease caused by persistent infection with Echinococcus multilocularis. Although more attention has been paid to the immunotolerance of T cells E. multilocularis infection, role natural killer (NK) cell, critical player in immunity, seldom studied. Approach Results Here, we observed that NK from blood closed tissue (CLT) AE patients expressed higher level inhibitory receptor TIGIT were functionally exhausted lower...
Echinococcus multilocularis larvae, predominantly located in the liver, cause a tumor-like parasitic disease, alveolar echinococcosis (AE), that is characterized by increased infiltration of various immune cells, including macrophages, around lesion produces an “immunosuppressive” microenvironment, favoring its persistent infection. However, role hepatic macrophages host defense against E. infection remains poorly defined. Using human liver tissues from patients with AE and experimental...
Immune exhaustion corresponds to a loss of effector function T cells that associates with cancer or chronic infection. Here, our objective was decipher the mechanisms involved in immune suppression myeloid-derived suppressor (MDSCs) and explore potential target these for immunotherapy enhance checkpoint blockade efficacy parasite We demonstrated programmed cell-death-1 (PD-1) expression significantly upregulated associated T-cell dysfunction advanced alveolar echinococcosis (AE) patients...
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal-inherited syndrome involving multiple tumors. It characterized by mutations in the tumor suppressor gene MEN1 , which located on chromosome 11q13. As main etiology of genetic mutations, clinical symptoms may vary. In this editorial, we comment article Yuan et al . This describes a case low incidence and diagnostic complexity. commonly presents as parathyroid, pancreatic, pituitary Diagnosis requires combination serologic tests,...
Echinococcus granulosus infection causes cystic echinococcosis (CE); the generation of liver fibrosis around parasitic larval cyst (metacestode) may play a major role in spontaneous limitation growth; however, fibrogenesis has received little attention CE. It been reported that miR-19b plays various diseases, including infectious by regulating fibrogenesis. However, its function development E. is unknown. The expression and genes are involved were analysed granulosus-infected human livers...
Adhesion molecules distributed on the cell-surface depends upon their dynamic trafficking that plays an important role during cancer progression. ADP-ribosylation factor 6 (Arf6) is a master regulator of membrane trafficking. CD147, tumor-related adhesive protein, can promote invasion liver cancer. However, Arf6 in CD147 and its contribution to progression remain unclear.Stable cell lines with silencing over-expression were established. Confocal imaging, flow cytometry, biotinylation...
The local immune mechanisms responsible for the establishment and development of Echinococcus granulosus sensu stricto infection in liver, have been little explored. We developed a suitable experimental model that mimics naturally infected livers using portal injection protoscoleces. Opposite to multilocularis which is dose-dependent, fully mature hydatid cysts can be established liver whatever dose; although most sites were seen at phase as inflammatory granulomas associated with fibrosis,...
Larvae of Echinococcus granulosus (sensu lato) dwell in host organs for a long time but elicit only mild inflammatory response, which indicates that the resolution inflammation is necessary parasite survival. The recruitment alternatively activated macrophages (AAMs) has been observed variety helminth infections, and emerging evidence AAMs are critical inflammation. However, whether can be induced by E. (s.l.) infection or thioredoxin peroxidase (TPx), one important molecules secreted...
The larval stage of the tapeworm Echinococcus granulosus sensu lato ( E. s.l. ) caused a chronic infection, known as cystic echinococcosis (CE), which is worldwide public health problem. human secondary CE by dissemination protoscoleces (PSCs) when fertile cysts are accidentally ruptured, followed development PSCs into new metacestodes. local immune mechanisms responsible for establishment and established phases after infection with s.l . not clear. Here, we showed that T cells were involved...
Alveolar echinococcosis (AE) is a severe chronic parasitic disease which behaves like slow-growing liver cancer. Clinical observations suggest that the parasite, Echinococcus multilocularis (E. multilocularis) influences homeostasis and hepatic cell metabolism. However, this has never been analyzed during time course of infection in common model secondary experimental mice.Gene expression profiles were assessed using DNA microarray analysis, 1, 2, 3 6 months after injection E. metacestode...
Background Alveolar echinococcosis (AE) is characterized by the tumor-like growth of Echinococcus (E.) multilocularis. Very little known on influence helminth parasites which develop in liver proliferation/growth arrest metabolic pathways hepatocytes infected over various stages infection. Methodology/Principal Findings Using Western blot analysis, qPCR and immunohistochemistry, we measured levels MAPKs activation, Cyclins, PCNA, Gadd45β, Gadd45γ, p53 p21 expression murine AE model, from day...
To investigate the role of CXC chemokine receptor (CXCR)-7 and CXCL12 in lymph node liver metastasis gastric carcinoma.
Human alveolar echinococcosis (AE) is a tumor-like disease predominantly located in the liver. The cellular composition and heterogeneity of lesion-infiltrating lymphocytes which produce an “immunosuppressive” microenvironment are poorly understood.
The process of immune photothermal therapy.
The cestode Echinococcus multilocularis, which mainly dwells in the liver, leads to a serious parasitic liver disease called alveolar echinococcosis (AE). Despite increased attention drawn immunosuppressive microenvironment formed by hepatic AE tissue, immunological characteristics of dendritic cells (DCs) have not been fully elucidated. Here, we profiled immunophenotypic DC subsets both clinical patients and mouse model. Single-cell RNA sequencing (scRNA-Seq) analysis four patient specimens...
Infection with the cestode Echinococcus multilocularis ( E . ) causes alveolar echinococcosis (AE), a tumor-like disease predominantly affecting liver but able to spread any organ. T cells develop functional defects during chronic infection, mostly due upregulation of inhibitory receptors such as T-cell immunoreceptor immunoglobulin and tyrosine-based motif domains (TIGIT) programmed death-1 (PD-1). However, role lymphocyte activation gene-3 (LAG3), an receptor, in AE infection remains be...