Nowadays, depression is the world’s major health concern and economic burden worldwide. However, due to limitations of current methods for diagnosis, a pervasive objective approach essential. In present study, psychophysiological database, containing 213 (92 depressed patients 121 normal controls) subjects, was constructed. The electroencephalogram (EEG) signals all participants under resting state sound stimulation were collected using prefrontal‐lobe three‐electrode EEG system at Fp1, Fp2,...

Background Coronavirus disease 2019 (COVID-19) has progressively impacted our daily lives, resulting in unexpected physical and mental stress on medical staff. This study is designed to investigate the levels of risk factors for burnout, depression, anxiety, insomnia among staff during COVID-19 epidemic breakout Shanghai, China. Methods cross-sectional survey was conducted from May 1 31, 2022, who were frontline Shanghai different institutions. The MBI-HSS used assess PHQ-9, GAD-7 ISI...

Cart (cocaine- and amphetamine-regulated transcript) was first identified to be a major brain mRNA up-regulated by cocaine amphetamine. The CART protein has been established as satiety factor closely associated with the action of leptin. To assess CART's role an anorexigenic signal, we have generated CART-deficient mice gene targeting. On high fat diet, female heterozygous mice, but not male showed statistically significant increases in weekly food consumption, body weight, mass compared...

To evaluate the short-term efficacy of acupuncture for treatment peri-menopausal insomnia (PMI). Design: A randomized, participant-blind, placebo-controlled trial consisted group (n = 38) and placebo-acupuncture 38). Setting: tertiary teaching general hospital. Participants: 76 women with disorder based on International Classification Sleep Disorders, Third Edition. Interventions: 10-session at bilateral Shenshu (BL 23) Ganshu 18) unilateral Qimen (LR 14) Jingmen (GB 25) or Streitberger...

Abstract Background Baricitinib is approved for the treatment of adults with severe alopecia areata (AA). In absence robust data on patterns regrowth during AA, there a gap in knowledge regarding expectations. Objectives To examine whether different clinical response subgroups could be identified baricitinib-treated patients AA and factors that contribute to these subgroups. Methods The BRAVE-AA1 BRAVE-AA2 phase III trials enrolled [Severity Alopecia Tool (SALT) score ≥ 50 (≥ 50% scalp hair...

This post hoc analysis assessed association between scalp hair regrowth and improvements in health-related quality of life (HRQoL) psychological burden patients with severe alopecia areata (AA).Data were pooled from two phase-3 trials (N = 1200). Patients randomized to once-daily placebo, baricitinib 2-mg, or 4-mg analyzed independently treatment allocation, categorized according (at Week 36): meaningful (Severity Alopecia Tool (SALT) score ≤20); intermediate (≥30% SALT improvement [SALT30]...

Introduction: Previous data on baricitinib treatment in severe alopecia areata (AA) has shown that response varies by baseline disease severity and duration of current episode. In general, hair regrowth varies, clinicians lack how long to optimally treat patients achieve response. the literature, time onset improvement (defined as 30% from SALT score, i.e. SALT30 can predict ultimate achievement score ≤20 Week 52. this analysis, we evaluated improvement(SALT30) meaningful response(SALT ≤20),...

To evaluate protein C and other factors associated with the septic response as predictors of mortality in a clinically relevant animal model sepsis.Laboratory investigation.Eli Lilly Company discovery research laboratory.Forty female Sprague Dawley rats weighing 245-265 g.Polyethylene catheters were surgically implanted into femoral vein sepsis was induced by cecal ligation puncture (CLP). A solution 5% dextrose 0.9 % saline continuously infused via immediately following surgery. Blood...

Atopic dermatitis (AD) is a chronic, inflammatory skin disease characterized by heterogeneous clinical phenotypes and high symptom burden, especially through itch. Baricitinib (BARI), an oral Janus Kinase 1/2 inhibitor, approved in Europe, Japan, other countries, for treatment of adults with moderate-to-severe AD who are candidates systemic therapy. This post hoc analysis Phase 3 topical corticosteroid (TCS) combination therapy trial (BREEZE-AD7) aims to characterize patients might benefit...

Acupuncture is emerging as an alternative therapy for rheumatoid arthritis (RA). However, the molecular mechanism underlying this beneficial effect of acupuncture has not been fully understood. Here, we demonstrated that electroacupuncture at acupoints Zusanli (ST36), Xuanzhong (GB39); and Shenshu (BL23) markedly decreased paw swelling histologic scores inflammation in synovial tissue, reduced body weight loss adjuvant-induced rat model. electrical stimulation nonacupoint did produce any...

Abstract Introduction Mild‐Alzheimer's disease (AD) subjects without significant Aβ pathology represent a confounding finding for clinical trials because they may not progress clinically on the expected trajectory, adding variance into analyses where slowing of progression is being measured. Methods A prediction model based structural magnetic resonance imaging (MRI) in combination with baseline demographics and measurements was used to impute status placebo‐treated mild‐AD sub‐cohort (N =...

To evaluate the efficacy and safety of acupuncture at HT 7 (Shenmen) KI (Fuliu) on sleep comorbid symptoms for chronic insomnia.

The paper studies the effects of long-term care insurance (LTCI) program in China on mental health older adults and wellbeing their families. We employ staggered difference-in-differences approach based LTCI pilots from 2015 to 2017. First, we find improves adults' happiness reduces depression symptoms significantly. improvement memory cognition are associated with elderly activities daily living-related need for care. Second, partially mediated through providing community services,...

Objective Imbalance between T-helper 17 (Th17) cells and regulatory T (Treg) is causally linked to the development of rheumatoid arthritis (RA). In this study, we tested hypothesis that electroacupuncture (EA) confers therapeutic benefits in RA through activation vasoactive intestinal peptide (VIP)-dependent signalling restoration Th17/Treg cell balance. Materials Methods A collagen-induced (CIA) model was induced Sprague–Dawley rats by injection bovine type II collagen incomplete Freund's...

Locally advanced rectal cancer (LARC) is frequently treated with neoadjuvant chemoradiotherapy (NACRT) to reduce the risk of local recurrence and improve survival. Tumour response NACRT variable may influence prognosis after subsequent surgery. This study compared prognostic values tumour regression grade (TRG) pathological (ypTNM) downstaging in patients Stage II III followed by curative surgery.This included 185 LARC long-course radiotherapy (45 Gy 25 fractions) plus 5-fluorouracil over 5...

The present study aims to explore the presence of asymmetry within relationship between energy consumption, air quality and economic growth in China by adopting NARDL model. findings confirm a bi-directional asymmetric short long-term. effects positive negative these variables shocks are various sign magnitude. Specifically, impacts consumption on development bigger than shocks. Real output is also an important determinant quality. relationships among three not necessary be or positive, but...

Recently, there has been interest in the relationship between mental health and air pollution; however, results are inconsistent contribution of foreign direct investment (FDI) received little attention. This article studies effects pollution on moderating role FDI based China Health Retirement Longitudinal Study (CHARLS) data 2015 2018 applying fixed panel regression approach threshold model. The show that is adversely affected by pollution, especially PM 2.5 , 10 sulfur dioxide (SO 2 ),...

To evaluate the efficacy and safety of acupuncture compared to that parecoxib sodium on postoperative pain (POP), nausea vomiting (PONV), Bruggemann Comfort Scale (BCS) in patients following laparoscopic cholecystectomy (LC).Eligible admitted hospital for LC were randomly allocated either or control groups a 1 : ratio. The subjects group received while those injected by at their requests. score, PONV BCS assessed 0 h, 6 9 12 h after operation. primary outcome was score. secondary outcomes...

The effects of hyperglycemia and insulin therapy on septic outcome have not been well studied.Septic was induced by infusion TPN (254 kcal/kg x d) immediately following cecal ligation puncture (CLP) surgery in rats. Animals (N = 109) were monitored for blood glucose followed survival 4 days. Separate cohorts 36) sacrificed at 22 hours post-CLP analyzed cytokines/chemokines, hormones, organ damage markers. treatment day also examined 60).Hyperglycemic animals had significantly higher (p <...

In adults with atopic dermatitis (AD), head and/or neck involvement is frequent, bothersome, and impacts quality of life, however, long-term topical corticosteroids (TCS) are contraindicated for this difficult-to-treat region. Baricitinib, an oral, selective, reversible inhibitor Janus kinase 1/2 has demonstrated efficacy in adult patients moderate-to-severe AD. For post hoc analysis, data from five Phase III trials were used to investigate the baricitinib involvement. Data obtained...