A5100417725- High Entropy Alloys Studies
- High-Temperature Coating Behaviors
- Metal and Thin Film Mechanics
- Advanced materials and composites
- Diamond and Carbon-based Materials Research
- Intermetallics and Advanced Alloy Properties
- Advanced ceramic materials synthesis
- Metallic Glasses and Amorphous Alloys
- MXene and MAX Phase Materials
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- Additive Manufacturing Materials and Processes
- Nuclear materials and radiation effects
- COVID-19 and Mental Health
- Glass properties and applications
- Acupuncture Treatment Research Studies
- Retinoids in leukemia and cellular processes
- Iron-based superconductors research
- Advanced Data Storage Technologies
- Rare-earth and actinide compounds
- Signaling Pathways in Disease
- Endoplasmic Reticulum Stress and Disease
- Sleep and Wakefulness Research
- Sleep and related disorders
- Maritime Ports and Logistics
Sir Run Run Shaw Hospital
2024
Zhejiang University
2024
Yueyang Hospital
2024
Shanghai University of Traditional Chinese Medicine
2024
Dalian University
2024
Dalian University of Technology
2023-2024
Nanjing Institute of Technology
2022-2023
Southeast University
2022-2023
Institute of High Energy Physics
2023
Chinese Academy of Sciences
2019-2023
Dysregulated alternative splicing events have been implicated in many types of cancer, but the underlying molecular mechanisms remain unclear. Here, we observe that factor SRSF1 regulates DBF4B exon6 by specifically binding and promoting its inclusion. Knockdown exon6-containing isoform (DBF4B-FL) significantly inhibits tumorigenic potential colon cancer cells vitro mice, inactivation phenocopies DBF4B-FL depletion. are required for cell proliferation maintenance genomic stability....
In this paper,a high strength Al-4.82Mg-0.75Sc-0.49Mn-0.28Zr (Al–Mg-Sc-Mn) alloy was prepared by selective laser melting (SLM). The effects of power on microstructures, relative density, and mechanical properties SLM-fabricated Al–Mg-Sc-Mn were studied. results shown that the bimodal structure with an ultra-equiaxed grain columnar crystal is formed in Slammed-fabricated alloy. surrounded ultra-fine equiaxed crystal, shows (001) preferred orientation, no anisotropy With increase power, molten...
Through particle swarm optimization algorithm and first-principles structural optimizations, we have predicted two novel low-energy structures of BC7: graphite-like Amm2 structure diamond-like P-4m2 structure. Structural stability the proposed BC7 polymorphs was confirmed by calculating elastic constants phonon frequencies. Phase transition pressure from to determined be at 2.2 GPa. Calculations for electronic band demonstrated hole-type conductivity phases. Ideal tensile strength along...
Dysregulation of calcium homeostasis endoplasmic reticulum protein (CHERP) has been implicated in several cancers, but it remains elusive how CHERP contributes to cancer cell proliferation and development. Here, we observed that its binding partner SR140 are significantly upregulated human clinical colorectal tissues (CRC). could form a complex stabilize each other. Knockdown or triggers double-stranded DNA breaks death. Furthermore, UPF3A, the RNA surveillance factor, was identified as...
The effects of cryogenic thermal cycling (CTC) treatment on tensile plasticity and structure change [(Fe0.5Co0.5)0.75B0.2Si0.05]96Nb4 metallic glass (MG) ribbons were systematically investigated. Pronounced β-relaxation peaks locating at 643 693 K observed after CTC with diverse temperatures. Specifically, the treated samples exhibiting most remarkable showed plastic strain 5.2% 4% K, while as-quenched sample only 3% 2.1% K. pronounced enhanced are considered to be originated from increased...
Drugs that target reactive oxygen species (ROS) metabolism have progressed the treatment of pancreatic cancer treatment, yet their efficacy remains poor because adaptation cells to high concentration ROS. Cells cope with ROS by recognizing 8-oxoguanine residues and processing severely oxidized RNA, which make it feasible improve ROS-modulating drugs in targeting regulators.
Restless legs syndrome (RLS) is a sensorimotor disorder of the nervous system that mainly characterized by nighttime leg discomfort and can be accompanied significant anxiety, depression, other mood disorders. RLS seriously affects quality life. Clinical studies have confirmed acupuncture alleviate clinical symptoms RLS. This randomized controlled trial (RCT) aims to investigate efficacy in treatment further explore central response mechanism In this RCT, total 124 eligible patients Shanghai...
High-entropy alloys (HEAs) have shown promising potential applications in advanced reactors due to the outstanding mechanical properties and irradiation tolerance at elevated temperatures. In this work, novel low-activation Ti2ZrHfxV0.5Ta0.2 HEAs were designed prepared explore high-performance under irradiation. The microstructures of before after investigated. results showed that unirradiated displayed a single-phase BCC structure. yield strength increased gradually with increase Hf content...
By doping titanium hydride (TiH 2 ) into boron carbide (B 4 C), a series of B C + x wt% TiH ( = 0, 5, 10, 15, and 20) composite ceramics were obtained through spark plasma sintering (SPS). The effects the temperature amount additive on microstructure, mechanical electrical properties sintered C-TiB investigated. Powder mixtures with 0–20 heated from 1400 °C to 1800 for 20 min under 50 MPa. results indicated that higher temperatures contributed greater ceramic density. With increasing...
Recent discovery of superconductivity in YbRh$_2$Si$_2$ has raised particular interest its pairing mechanism and gap symmetry. Here we propose a phenomenological theory investigate possible structures by solving the multiband Eliashberg equations combining realistic Fermi surfaces from first-principles calculations quantum critical form magnetic interactions. The resulting symmetry shows sensitive dependence on in-plane propagation wave vector fluctuations, suggesting that is located border...