A5019813887- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV, Drug Use, Sexual Risk
- HIV/AIDS drug development and treatment
- Sex work and related issues
- Syphilis Diagnosis and Treatment
- Hepatitis C virus research
- Pneumocystis jirovecii pneumonia detection and treatment
- Advanced Neuroimaging Techniques and Applications
- Alzheimer's disease research and treatments
- Epilepsy research and treatment
- Cytomegalovirus and herpesvirus research
- Virology and Viral Diseases
- Dementia and Cognitive Impairment Research
- Data-Driven Disease Surveillance
- Herpesvirus Infections and Treatments
- Reproductive tract infections research
- Neonatal and fetal brain pathology
- Female Genital Mutilation/Cutting Issues
- Frailty in Older Adults
- Healthcare Systems and Public Health
- Treatment of Major Depression
- Genital Health and Disease
- SARS-CoV-2 detection and testing
- Cardiovascular Health and Risk Factors
Sichuan Center for Disease Control and Prevention
2016-2025
Nanjing University of Science and Technology
2025
Chengdu University of Traditional Chinese Medicine
2021-2023
Center for Disease Control
2023
Guangxi Center for Disease Prevention and Control
2020
Centers for Disease Control and Prevention
2014
University of Alabama at Birmingham
2006
Peking University
2004
The objective of this study was to investigate the prevalence and risk factors syphilis infection among female sex workers in a southwestern Chinese city along drug trafficking route.From December 2004 January 2005, 343 (FSWs) were recruited through community outreach peer referring. Confidential questionnaire interviews administered collect information on sexual other sexually transmitted diseases/HIV behaviors. Cervical blood samples collected test for HIV antibodies Neisseria gonorrhoeae...
To investigate the epidemiological relationships between HIV-1 strains that are spread among men who have sex with (MSM) populations of 9 cities across China and to analyze origins divergence times major epidemic found in MSM population.A total 583 HIV-1-positive subjects were recruited from high-risk 2009 2011. Nucleotide sequences 1.0-kb pro-RT regions amplified sequenced. Phylogenetic Bayesian molecular clock analyses performed.The overall distribution genotypes was as follows: CRF01_AE,...
Abstract The HIV-1 epidemic among men-who-have-sex-with-men (MSM) continues to expand in China, involving the co-circulation of several different lineages strains, including subtype B and CRF01_AE. This expansion has created conditions that facilitate generation new recombinant strains. A molecular epidemiologic survey MSM 11 provinces/cities around China was conducted from 2008 2013. Based on pol nucleotide sequences, a total 19 strains (1.95%) belonged CRF55_01B were identified 975 7...
To investigate the incidence rates of HIV, hepatitis C virus (HCV), and B (HBV) among injection drug users (IDU) in a trafficking city southwest China.A prospective cohort study.A 333 HIV-seronegative IDU was followed for 36 months from November 2002 evaluated every 6 seroconversions to HIV HCV antibodies as well surface antigen. Questionnaire interviews were conducted collect information about risk behaviors.Some 68.8% subjects completed last follow-up survey. A total 14 47 51 HBV observed...
Background China's National Free Antiretroviral Treatment Program (NFATP) has substantially increased the survival rate since 2002. However, emergence of HIV drug resistance (HIVDR) limits durability and effectiveness antiretroviral treatment (ART) in at risk patients. Method A cross-sectional survey was conducted among patients having received a median 13.9 months ART eight provinces China. Demographic clinical information collected, venous blood sampled for CD4 cell counts, measurement...
Abstract As the most dominant HIV-1 strain in China, CRF01_AE needs to have its evolutionary and demographic history documented. In this study, we provide phylogenetic analysis of all pol sequences identified mainland China. were collected from Los Alamos HIV Sequence Database local Chinese provincial centers disease control prevention. Phylogenetic trees constructed identify major epidemic clusters. Bayesian coalescent-based method was used reconstruct time scale history. There 2965 24...
Abstract Background After the scale-up of antiretroviral therapy (ART) for HIV infected people, increasing numbers patients have pretreatment drug resistance (PDR). In this study, prevalence PDR was evaluated in adults initiating China. Methods Blood samples were obtained from 1943 who initiated 2017 13 provinces or cities Pol sequences used to analyze and construct transmission networks. Logistic regression model estimate potential factors associated with PDR. Results total, 1711 eligible...
Sichuan province is one of the highest AIDS epidemic provinces in China, with a large number floating population. The annual cases HIV/AIDS reported has been China for several successive years. There lack widespread and representative data on distribution HIV genotypes Sichuan. We aim to investigate characteristics HIV-1 molecular epidemiology transmitted drug-resistance newly diagnosed HIV-infected patients Sichuan, China.
Existing studies qualitatively rather than quantitatively described the influence of mechanical property parameters impacted body on overload signal characteristic (acceleration peak AP and pulse width PW) projectile. The model static PW projectile were developed in this work. properties changed by heat treatment. maximum relative errors projectiles predicted versus experimental results 1.4% 3.4%, respectively. simulated finite element software 14.1% 24.2%, effect treatment was explained. It...
This study aimed to investigate the characteristics of HIV-1 molecular network among newly diagnosed HIV-infected patients in southern Sichuan City. Plasma samples will be collected from eligible subjects (n = 1249) during a cross-sectional survey conducted between 2016 and 2020. The polymerase (pol) gene sequences obtained used perform phylogenetic analysis characterize genetic subtypes' transmission networks. pol region were successfully amplified 898 cases, seven genotypes obtained, with...
The aim of this study was to evaluate the impact a multifaceted harm reduction program by comparing seroincidence rates HIV, hepatitis C virus (HCV), B (HBV), and syphilis before after implementation strategies among intravenous drug users (IDUs) in drug-trafficking city Southwest China.This is prospective cohort with 24 months follow-up.Two cohorts (cohort 2002-2004 2006-2008) were followed up every 6 for seroconversions HCV, antibodies HBV surface antigen.After Xichang city, Sichuan...
Liangshan Yi Autonomous Prefecture is one of the areas that most severely affected by human immunodeficiency virus (HIV) in China, and virological failure on antiretroviral therapy (ART) serious this area. Analyses prevalence determinants ART failure, genetic diversity drug resistance among people living with HIV (PLWH) helps improve treatment efficiency prevent transmission.A total 5157 PLWH were recruited from 2016 to 2017. The venous blood samples subjected RT-PCR, followed sequencing...
Sichuan Province is severely affected by the HIV epidemic in China. Little known about characteristics of recent infections among new diagnoses, which critical to prevention strategies, evaluation and health resource allocation. Meanwhile, individuals at primary stages infection are related hot-spot areas ongoing transmission also rarely known.This article aimed report proportion reveal demographic associated with infections, finally, indicate province between 2018 2020.Limiting Antigen...
In recent years, the men who have sex with (MSM) population has seen fastest growing prevalence of HIV transmission in China. addition, coinfection through and intravenous drug use is a major problem prevention control. Recent studies also revealed that three viral strains (CRF07_BC, CRF01_AE, subtype B) been cocirculating among MSM Sichuan, suggesting high probability generating new recombinants. This study reports near full-length genome novel HIV-1 recombinant (MSM0720) between CRF07_BC...
Antiretroviral therapy (ART) has been introduced recently and significantly impacted morbidity mortality, but can also engender drug resistance. To identify the prevalence of HIV-1 resistance (HIVDR) among patients with antiretroviral failure in Sichuan during period from 2010 to 2016, we carried out a longitudinal study Sichuan, province highest HIV/AIDS China. The data blood samples were collected who received ART for more than half year. Overall 5,512 sequences completed 7,059 ART-failure...
Spatialized HIV genetic transmission networks can help understand dynamic changes of HIV-1 at the regional level. This study aimed to combine genomic, epidemiological, and spatial data investigate patterns epidemic both individual levels among people living with (PLWH) virological failure antiretroviral therapy (ART).
To investigate factors associated with HIV infection and the frequency willingness of male circumcision among men who have sex (MSM) in Chengdu city, China. A cross-sectional survey provided information on participants' demographics, risk behaviors, circumcision, uptake prevention services. Of 570 participants, 13.3% were infected 15.9% syphilis. An estimated 43.0% respondents reported having unprotected receptive anal intercourse, 58.9% ≥2 sexual partners past 6 months. Multivariable...
We aimed to investigate the molecular epidemic characteristics and viral transmission patterns of HIV-1 in a typical labor export area, Guangyuan city, China. Based on conducting phylogenetic trees networks, analysis was performed pol sequences obtained from 211 migrant-history workers, 83 non-migrant-history individuals, 21 unknown individuals between January, 2012 February, 2017 city. Phylogenetic revealed that CRF07_BC (48.3%, n = 152) CRF01_AE (33.3%, 105) were dominant strains...
Background: Pretreatment drug resistance (PDR) poses an increasing threat to the success of antiretroviral treatment (ART) programs in China. We aimed conduct a survey PDR among HIV patients area Southwest China with extensive trafficking. Methods: Consecutive cross-sectional surveys were conducted Liangshan Prefecture Sichuan Province from 2009 2018 based on WHO-recommended method. was identified by testing pol region sequences Stanford HIVdb algorithm (version 7.0). prevalence and related...
Patients with antiretroviral therapy interruption have a high risk of virological failure when re-initiating (ART), especially those HIV drug resistance. Next-generation sequencing may provide close scrutiny on their minority resistance variant. A cross-sectional study was conducted in patients ART five regions China 2016. Through Sanger and next-generation parallel, genotyped plasma samples. Rates were compared by the McNemar tests. In total, 174 included this study, median 12...
Abstract This study sought to examine the human immunodeficiency virus type 1 (HIV-1) genetic diversity on drug resistance among men who have sex with (MSM) virologic failure in antiretroviral therapy (ART), and investigate linking-associated factors for transmission networks. Seven hundred thirty-four HIV-positive MSM ART were recruited into our from 2011 2017. HIV-1 pol gene sequences used phylogenetic genotypic analyses. The mutations determined using Stanford University HIV Drug...
The objective of this study was to understand the molecular transmission characteristics newly reported HIV infections in city Pengzhou, Sichuan Province, analyze risk factors network and spatial clustering characteristics, provide a scientific basis for precision prevention intervention.Anticoagulated whole blood collected from Pengzhou March 2019 August 2021. After plasma isolated, HIV-1 pol gene amplified sequenced by reverse transcriptase polymerase chain reaction (PCR). obtained...