A5101407277- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV, Drug Use, Sexual Risk
- Sex work and related issues
- HIV/AIDS drug development and treatment
- Adipose Tissue and Metabolism
- Adolescent Sexual and Reproductive Health
- Viral Infections and Vectors
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Hepatitis B Virus Studies
- Medicinal Plant Pharmacodynamics Research
- Traditional Chinese Medicine Analysis
- LGBTQ Health, Identity, and Policy
- Pneumocystis jirovecii pneumonia detection and treatment
- Liver Disease Diagnosis and Treatment
- Sexuality, Behavior, and Technology
- HIV, TB, and STIs Epidemiology
- T-cell and Retrovirus Studies
- Aortic aneurysm repair treatments
- Herpesvirus Infections and Treatments
- Lipid metabolism and disorders
- Vascular Malformations and Hemangiomas
- Cardiac Ischemia and Reperfusion
- Hormonal Regulation and Hypertension
Shandong Center for Disease Control and Prevention
2011-2021
Centers for Disease Control and Prevention
2013
Qilu Hospital of Shandong University
2012
Academy of Medical Sciences
2012
Shandong Tumor Hospital
2012
China Pharmaceutical University
2009-2012
Shandong First Medical University
2012
Qingdao University
2003
The HIV epidemic among former plasma donors (FPDs) in rural Central China the early-mid 1990s is likely largest known HIV-infected cohort world related to commercial donation but has never been fully described. objectives of this study are estimate timing and geographic spread infection demonstrate impact antiretroviral therapy on survival outcomes.HIV-infected FPDs were identified using national epidemiology treatment databases. Locations subjects mapped. Dates estimated midpoint date...
To investigate the epidemiological relationships between HIV-1 strains that are spread among men who have sex with (MSM) populations of 9 cities across China and to analyze origins divergence times major epidemic found in MSM population.A total 583 HIV-1-positive subjects were recruited from high-risk 2009 2011. Nucleotide sequences 1.0-kb pro-RT regions amplified sequenced. Phylogenetic Bayesian molecular clock analyses performed.The overall distribution genotypes was as follows: CRF01_AE,...
Abstract The HIV-1 epidemic among men-who-have-sex-with-men (MSM) continues to expand in China, involving the co-circulation of several different lineages strains, including subtype B and CRF01_AE. This expansion has created conditions that facilitate generation new recombinant strains. A molecular epidemiologic survey MSM 11 provinces/cities around China was conducted from 2008 2013. Based on pol nucleotide sequences, a total 19 strains (1.95%) belonged CRF55_01B were identified 975 7...
Recent upsurge of new HIV infections among men who have sex with (MSM) is a major concern in China. Paucity national-level information regarding the burden and predictors this progressive epidemic called for multi-centric, timely comprehensive investigation.Mixed methods were used to recruit MSM from seven cities China between 2012 2013. established estimated by Western Blot BED HIV-1 capture enzyme immunoassay. Syphilis herpes simplex virus-2 (HSV-2) also tested.A total 4496 eligible...
Highly active antiretroviral therapy (HAART) has significantly decreased mortality among Chinese HIV patients. However, emerging drug resistance (HIVDR) poses a growing threat to the long-term success and durability of HAART.Three cross-sectional surveys were conducted across country from 2004 2006, respectively. Patients completed questionnaire provided blood for CD4 cell count, viral load (VL), genotyping. Factors associated with HIVDR identified by logistic regression.3667 unique patients...
A critical indicator of the future success highly active antiretroviral therapy (HAART) is incidence HIV drug resistance, which has not been studied in China on national scale.HIV resistance baseline survey was conducted eight provinces with largest numbers patients HAART 2009, and a prospective cohort study 12-month follow-up completed 2010. Patients an interviewer-administrated questionnaire provided blood for CD4+ T-lymphocyte count (CD4 count), viral load (VL), genotyping. Factors...
The HIV-1 epidemic among men-who-have-sex-with-men (MSM) continues to expand in China. A large-scale national survey we conducted on strains MSM 11 provinces China from 2008 2013 (n = 920) identified a novel transmission cluster consisting of six (0.7%) that belonged new circulating recombinant form (designated CRF59_01B). CRF59_01B contains two subtype B segments U.S.-European origin (in the pol and vpu-env regions) CRF01_AE backbone. is second CRF (after CRF55_01B) primarily occurs at low...
A study of female sex workers in China, found alarmingly high prevalence methamphetamine use. Methamphetamine users were more likely to be single, younger, inconsistent condom users, and have syphilis.
Objectives: To elucidate new features in the prevalence of HIV-1 transmitted drug resistance (TDR) men who have sex with (MSM) China. Methods: A total 441 HIV-1–positive subjects were recruited from high-risk MSM populations 7 cities across China between 2012 and 2013. Nucleotide sequences 1.1-kb pol-RT regions amplified sequenced 367 samples. Phylogenetic genetic drug-resistant analyses performed. Results: The overall distribution genotypes was as following: CRF01_AE, 52.3%; CRF07_BC,...
Abstract Background There is limited information about the types of recreational drugs used by men who have sex with (MSM) in China or consequent impact on sexual health and human immunodeficiency virus (HIV) acquisition. Methods We recruited MSM from seven cities between 2012 2013 using multiple approaches including advertisements gay websites, collaborating local community-based organizations, peer referrals, venues such as bars bathrooms visited MSM. divided participants into four...
Literature on the age at first anal intercourse (AFAI) among men who have sex with (MSM) is limited. We aimed to elucidate evolution of AFAI and factors associated early AFAI, based a large sample MSM in China.We collected information demographics sexual behaviours from seven cities China 2012 2013. Blood samples were for HIV serology. was calculated born different time periods. Linear regression models used explore younger AFAI.A total 4491 (median age: 27 years, median AFAI: 21 years)...
Men who have sex with men (MSM) are at high risk of HIV and sexually transmitted infections (STIs) in China globally. Engaging commercial put them even greater risk. This study estimated the prevalence HIV/STIs among three subgroups MSM: MSM sold (MSM-selling), bought (MSM-buying), non-commercial (NC-MSM) evaluated relationship between HIV/STIs.We conducted a cross-sectional survey six Chinese cities (Shenyang, Ji'nan, Changsha, Zhengzhou, Nanjing, Kunming) from 2012 to 2013. Data on...
Heterosexual transmission of HIV through contact with female sex workers (FSWs) is a growing concern for the HIV/AIDS epidemic in China. Using consecutive cross-sectional surveys, we examined prevalence and sexually transmitted infections (STIs), risk behaviours, knowledge utilization intervention services among FSWs Shandong Province. Of 3460 participants, half reported ever having STI-related symptoms, 57.8% had ≥7 clients last week, inconsistent use condoms 11.2% using illicit drugs....
Delayed or inappropriate treatment for sexually transmitted diseases (STDs) increases the risk of HIV acquisition and may cause other harmful outcomes. However, studies on STD treatment-seeking behaviour correlated factors in men who have sex with (MSM) are scarce. This information is crucial promotion reduction transmission among Chinese MSM. During 2012–2013, a multicentre cross-sectional study was conducted 7 cities. Participants completed an interview-questionnaire gave venous blood...
A survey to measure transmitted HIV-1 drug resistance (DR) was conducted in 2006 following the World Health Organization threshold protocol. Dried blood spots (DBS) were prepared from 53 newly HIV-1-diagnosed patients. Protease and reverse transcriptase (RT) gene regions sequenced using a broadly sensitive genotyping assay analyses identify DR mutations determine phylogeny of strains conducted. Forty-six 47 successfully genotyped DBS had no mutations; one an NNRTI mutation (K101E) RT region....
The efficacy of antiretroviral drugs is limited by the development drug resistance. Therefore, it important to examine HIV resistance following nationwide implementation testing in China since 2009. We conducted patients who were already on or new therapy (ART) Shandong Province, China, from 2011 2013, and grouped them based presence absence determine effects age, gender, ethnicity, marital status, educational level, route transmission treatment status then examined levels year. rates ART...
To investigate the role that DC-SIGN neck-region length variation plays in HIV-1 transmission, we studied 530 HIV-1-positive and 341 HIV-1-negative individuals China. The carrier frequency of a allele with <5 repeat units was 0.9% 3.8% (P = .007), an observation suggesting this transmission. These naturally occurring variants were significantly more frequent Chinese population than US (P<.001) worldwide .006).
Objectives Traditionally, subjects' migration status has usually been defined on the basis of their registered residency status. We attempted to redefine based duration in cities and explore more precisely impact HIV infection risk men who have sex with (MSM). Methods A multisite cross-sectional study was conducted during 2012–2013 seven Chinese cities. Questionnaire surveys were blood drawn test for antibodies HIV, syphilis herpes simplex virus-2 (HSV-2). MSM unregistered local residents...
Shandong province has been providing antiretroviral therapy (ART) to eligible HIV/AIDS patients since 2003 using first-line regimens. We conducted a cross-sectional study assess virological response and resistance development from ART patients. Between 2006 2008, blood was collected 143 Viral load (VL) determined with detection limit of 50 copies/ml; those detectable VL were genotyped dried plasma spots broadly sensitive genotyping assay. Resistance mutations identified the Stanford HIV drug...