A5101886949- Dementia and Cognitive Impairment Research
- Spine and Intervertebral Disc Pathology
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Schizophrenia research and treatment
- Cervical and Thoracic Myelopathy
- Advanced MRI Techniques and Applications
- Mental Health and Psychiatry
- Hereditary Neurological Disorders
- Genetic Neurodegenerative Diseases
- Psychosomatic Disorders and Their Treatments
- Shoulder Injury and Treatment
- Photoacoustic and Ultrasonic Imaging
- Pelvic and Acetabular Injuries
- Botulinum Toxin and Related Neurological Disorders
- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Infrared Thermography in Medicine
- Musculoskeletal synovial abnormalities and treatments
- Shoulder and Clavicle Injuries
- Bone and Joint Diseases
- Multiple Myeloma Research and Treatments
- Management of metastatic bone disease
- Spinal Fractures and Fixation Techniques
- Cerebrovascular and Carotid Artery Diseases
Peking University Third Hospital
2004-2024
Peking University
2004-2024
Objective Charcot–Marie–Tooth (CMT) disease is the most common inherited neuromuscular disorder. Multi-echo Dixon MRI technique a highly sensitive method for quantifying muscle fatty infiltration, which may provide excellent value assessment of CMT. Due to rareness disease, its use in CMT has been rarely evaluated, especially subtypes. Methods Thirty-four CMT1 patients, 25 CMT2 and 10 healthy controls were recruited. All recruited patients are CMT1A with PMP22 duplication. Among 7 CMT2A MFN2...
Abstract The present study aimed to explore the effect of computerized multi-domain cognitive training (MDCT) on brain gray matter volume and neuropsychological performance in patients with amnestic mild impairment (amnestic MCI). Twenty-one MCI participated a MDCT program. program targeted broad set domains via programs focused reasoning, memory, visuospatial, language, calculation, attention. Seventeen Participants completed intervention all battery tests evaluate function while 12 out 17...
Widespread cortical gray matter alternations in people with schizophrenia are correlated both psychotic symptoms and cognitive/behavioral abnormalities, including the impairments of exploratory eye movement (EEM). Particularly, loss density is specifically related to deficits responsive search score (RSS) EEM schizophrenia. It unknown, however, whether schizophrenia-related RSS associated certain symptoms, such as hallucinations.In 33 participants schizophrenia, measurement EEM, assessment...
Schizophrenic patients present abnormalities in a variety of eye movement tasks. Exploratory (EEM) dysfunction appears to be particularly specific schizophrenia. However, the underlying mechanisms EEM schizophrenia are not clearly understood. To assess potential neuroanatomical substrates EEM, we recorded performance and conducted voxel-based morphometric analysis gray matter 33 schizophrenic 29 well matched healthy controls. In patients, decreased responsive search score (RSS) widespread...
Background: Vertebral hemangioma (VH) is one of the most common benign spinal tumors and can be aggressive in some cases. While VHs have typical radiographic features, including vertical striations, a honeycomb appearance, and/or “polka-dot sign” computed tomography (CT) scans, cases with atypical features might complicate diagnosis. This study aimed to determine range frequency these features. Methods: In this retrospective study, identify VH, pretreatment CT magnetic resonance imaging...
Background : To investigate the anatomical characteristics and symmetry of bilateral glenoid structures Chinese people to explore relationship between bone structure recurrent anterior dislocation. Materials Methods The control group included 131 individuals with no history shoulder dislocation consisted patients a unilateral All subjects underwent CT scans. Glenoid shape (pear-shaped, inverted comma-shaped, oval-shaped), width, height, depth, version angle, area, maximum fitting circle area...
To assess the diagnostic performance of three-dimensional ultrashort echo time sequence (3D-UTE) in bone erosion detection sacroiliac joint (SIJ) patients with ankylosing spondylitis (AS) and to test whether SIJ cartilage T2 * values might help identification AS.
This study used multi-factorial linear quantile mixed-effects regression models to predict the outcome of cervical spondylotic myelopathy (CSM) patients one year after surgery based on MRI. Six were constructed using mixed model and diffusion magnetic resonance imaging (dMRI) data, all data (dMRI & Conventional MRI), registered MRI clinical data). We found that fractional anisotropy (FA) values quantified by preoperative dMRI could surgical CSM showed a significant positive correlation...
This study investigated the performance of whole-body diffusion-weighted imaging (WBDWI), non-diffusion MRI, and 18F-FDG PET-CT in detecting spinal lesions patients with an initial diagnosis multiple myeloma (MM). The results showed that WBDWI discovered more compared both MRI 18F-PET-CT. And detection was not significantly decreased even degree marrow infiltration MM. suggests should be preferentially recommended examination for
Motivation: Early cervical spondylotic myelopathy (CSM) is challenging to diagnose and easily missed. Goal(s): To explore the value of diffusion MRI (dMRI) in diagnosing early-stage CSM evaluating uncompressed segments patients with early CSM. Approach: Using tensor imaging (DTI), kurtosis (DKI), neurite orientation dispersion density (NODDI), a 1:1 matched case control study was conducted. Results: The division index (ODI) positively correlated CSM, anisotropic water fraction (AWF)...
Executive dysfunction is an important characteristic of Alzheimer's disease (AD). Verbal fluency a component executive function. This study aimed to investigate the structural neuroimaging correlates verbal in amnestic mild cognitive impairment (aMCI) and (AD), using optimized voxel-based morphometry (VBM). Fifty-six patients with AD (NINCDS-ADRDA criteria, group), 14 subjects aMCI meeting Petersen criteria (aMCI 16 healthy elderly (control group) were enrolled this study. All completed...
Amnestic mild cognitive impairment (aMCI) is considered preclinical stage of Alzheimer's disease (AD). This study aimed to investigate the atrophy pattern in aMCI and AD using optimized voxel-based mophormetry (VBM) technique. Fourteen subjects meeting criteria proposed by Petersen (aMCI group), 56 patients with (NINCDS-ADRDA criteria, 16 healthy elderly controls (NC group) normal-appearing white matter were enrolled this prospective study. All underwent a comprehensive neuropsychological...
Cognitive impairment and late-life depression (LOD) are associated with increased risk for subsequent dementia. This study aimed to explore the neural correlates of memory performance executive function in LOD from structural neuroimaging perspective. Nine patients late-onset (ICD-10 criteria, group, age = 64.9 ± 9.2, male 4, female 5, MMSE 22.7 5.5), fourteen subjects meeting aMCI criteria proposed by Petersen (aMCI 72.6 4.9, 8, 6, 26.0 1.9), 16 healthy elderly controls (NC 69.9 2.8, 10,...