A5102992549- Bacterial Genetics and Biotechnology
- CRISPR and Genetic Engineering
- Bacterial biofilms and quorum sensing
- RNA and protein synthesis mechanisms
- Antimicrobial Resistance in Staphylococcus
- Tuberculosis Research and Epidemiology
- Cardiac Valve Diseases and Treatments
- Brucella: diagnosis, epidemiology, treatment
- Atherosclerosis and Cardiovascular Diseases
- Atrial Fibrillation Management and Outcomes
- Mycobacterium research and diagnosis
- Respiratory viral infections research
- Biochemical and Molecular Research
- Genetics, Aging, and Longevity in Model Organisms
- Bipolar Disorder and Treatment
- Biochemical and Structural Characterization
- Yersinia bacterium, plague, ectoparasites research
- Neuroblastoma Research and Treatments
- Photosynthetic Processes and Mechanisms
- Heat shock proteins research
- Coronary Interventions and Diagnostics
- Neuroendocrine Tumor Research Advances
- Galectins and Cancer Biology
- Tryptophan and brain disorders
- Hepatocellular Carcinoma Treatment and Prognosis
Inner Mongolia People's Hospital
2025
Chinese Academy of Sciences
2022-2024
Beijing Friendship Hospital
2024
Capital Medical University
2024
Wuhan Institute of Virology
2024
Qingdao University
2024
Qingdao Municipal Hospital
2024
Qingdao Institute of Bioenergy and Bioprocess Technology
2022-2023
Yantai Institute of Coastal Zone Research
2023
Qinghai New Energy (China)
2022
Background Mycoplasma pneumoniae ( M. ) is an important pathogen of community-acquired pneumonia in children. The factors contributing to the severity illness caused by infection are still under investigation. We aimed evaluate sensitivity common detection methods, as well analyze clinical manifestations, genotypes, macrolide resistance, respiratory microenvironment, and their relationship with children Wuhan. Results Among 1,259 samples, 461 samples were positive for via quantitative...
Nonhealing diabetic foot ulcers (DFU), a major complication of diabetes, are associated with high morbidity and mortality despite current standard care. Since Staphylococcus aureus is the most common pathogen isolated from nonhealing infected DFU, we hypothesized that S. virulence factors would damage tissue, promote immune evasion alter microbiome, leading to bacterial persistence delayed wound healing. In mouse polymicrobial model aureus, Pseudomonas aeruginosa, Streptococcus pyogenes,...
Introduction This study aims to utilize proteomics, bioinformatics, and machine learning algorithms identify diagnostic biomarkers in the serum of patients with acute chronic brucellosis Methods Proteomic analysis was conducted on samples from brucellosis, as well healthy controls. Differential expression performed proteins altered expression, while Weighted Gene Co-expression Network Analysis (WGCNA) applied detect co-expression modules associated clinical features brucellosis. Machine were...
Abstract Certain CRISPR-Cas elements integrate into Tn7-like transposons, forming CRISPR-associated transposon (CAST) systems. How the activity of these systems is controlled in situ has remained largely unknown. Here we characterize MerR-type transcriptional regulator Alr3614 that encoded by one CAST (AnCAST) system genes genome cyanobacterium Anabaena sp. PCC 7120. We identify a number homologs across cyanobacteria and suggest naming regulators CvkR for Cas V-K repressors. Alr3614/CvkR...
Abstract Background Atrial fibrillation (AF) is the most common cardiac arrhythmia worldwide. Catheter ablation has become a crucial treatment for AF. However, there possibility of atrial recurrence after catheter ablation. Our study sought to elucidate role lncRNA‒mRNA regulatory networks in late AF Methods We conducted RNA sequencing profile transcriptomes 5 samples from presence (P-RAF) and absence (A-RAF). Differentially expressed genes (DEGs) long noncoding RNAs (DE-lncRNAs) were...
The human pathogen Pseudomonas aeruginosa harbors three paralogous zinc proteases annotated as AmpD, AmpDh2, and AmpDh3, which turn over the cell wall cell-wall-derived muropeptides. AmpD is cytoplasmic plays a role in recycling of cell-wall muropeptides, with link to antibiotic resistance. AmpDh2 AmpDh3 are periplasmic enzymes; former anchored inner leaflet outer membrane latter soluble enzyme. We document herein that type VI secretion system locus II (H2-T6SS) P. delivers (but not or...
Abstract CRISPR-associated transposons (CASTs) exist in different groups of bacteria, including certain cyanobacteria, which contain type V-K CAST systems. These systems genes encoding Tn7-like transposase subunits and a divergent number cargo genes. How the activity these is controlled situ has remained largely unknown but possibly regulatory within elements are prime candidates. Deletion respective regulator gene alr3614 cyanobacterium Anabaena (Nostoc) sp. PCC 7120 led to overexpression...