A5026621683- RNA regulation and disease
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer-related gene regulation
- Endoplasmic Reticulum Stress and Disease
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Adipose Tissue and Metabolism
- Protein Degradation and Inhibitors
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Electron Spin Resonance Studies
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Air Quality and Health Impacts
- Intraocular Surgery and Lenses
- Eicosanoids and Hypertension Pharmacology
- Mesenchymal stem cell research
- Heart Failure Treatment and Management
- Ubiquitin and proteasome pathways
- Biochemical effects in animals
- Acute Lymphoblastic Leukemia research
- Free Radicals and Antioxidants
- Cardiovascular Function and Risk Factors
- Fatty Acid Research and Health
University of Chinese Academy of Sciences
2018-2024
Children's Hospital of Chongqing Medical University
2019
Chongqing Medical University
2019
China International Science and Technology Cooperation
2019
The clinical use of doxorubicin for cancer therapy is limited by its cardiotoxicity, which involves cardiomyocyte apoptosis and oxidative stress. Previously, we showed that general control nonderepressible 2 (GCN2), an eukaryotic initiation factor 2α (eIF2α) kinase, impairs the ventricular adaptation to chronic pressure overload affecting apoptosis. However, impact GCN2 on Dox-induced cardiotoxicity has not been investigated. In present study, treated wild type (WT) Gcn2-/- mice with four...
Fine particulate matter (PM2.5) airborne pollution increases the risk of respiratory and cardiovascular diseases. Although metformin is a well-known antidiabetic drug, it also confers protection against series diseases through activation AMP-activated protein kinase (AMPK). However, whether affects PM2.5-induced adverse health effects has not been investigated. In this study, we exposed wild-type (WT) AMPKα2−/− mice to PM2.5 every other day via intratracheal instillation for 4 weeks. After...
The development of nonalcoholic fatty liver disease (NAFLD) is associated with increased reactive oxygen species (ROS) production. Previous observations on the contradictory roles general control nonderepressible 2 (GCN2) in regulating hepatic redox state under different nutritional conditions prompted an investigation underlying mechanism by which GCN2 regulates ROS homeostasis. In present study, was found to interact NRF2 and decrease expression a KEAP1-dependent manner. Activation...
Choline acetyltransferase (ChAT)-positive neurons in neural stem cell (NSC) niches can evoke adult neurogenesis (AN) and restore impaired brain function after injury, such as acute ischemic stroke (AIS). However, the relevant mechanism by which ChAT
Abstract T-cell acute lymphoblastic leukemia (T-ALL) is a type of aggressive with inferior prognosis. Although activating mutations NOTCH1 are observed in most T-ALL cases, these alone not sufficient to drive the full development T-ALL. β-Arrestins (ARRB) versatile and multifunctional adapter proteins that regulate diverse cellular functions, including promoting cancer. However, role ARRBs has largely remained elusive. In this study, we showed ARRB1 expressed at low levels assayed clinical...
Dimethylarginine dimethylaminohydrolase 1 (DDAH1) is an important regulator of plasma asymmetric dimethylarginine (ADMA) levels, which are associated with insulin resistance in patients nonalcoholic fatty liver disease (NAFLD). To elucidate the role hepatic DDAH1 pathogenesis NAFLD, we used hepatocyte-specific Ddah1-knockout mice (Ddah1HKO) to examine progress high-fat diet (HFD)-induced NAFLD. Compared diet-matched flox/flox littermates (Ddah1f/f), Ddah1HKO exhibited higher serum ADMA...
Growing evidence suggests that dimethylarginine dimethylaminohydrolase 1 (DDAH1), a crucial enzyme for the degradation of asymmetric (ADMA), is closely related to oxidative stress during development multiple diseases. However, underlying mechanism by which DDAH1 regulates intracellular redox state remains unclear. In present study, was shown interact with peroxiredoxin (PRDX1) and sulfiredoxin (SRXN1), these interactions could be enhanced stress. HepG2 cells, H2O2-induced downregulation...
Abstract Background The adverse health effects of fine particulate matter (PM 2.5 ) exposure are associated with marked inflammatory responses. Adipose-derived stem cells (ADSCs) have immunosuppressive effects, and ADSC transplantation could attenuate pulmonary fibrosis in different animal disease models. However, whether ADSCs affect PM -induced lung injury has not been investigated. Method C57BL/6 mice were exposed to every other day via intratracheal instillation for 4 weeks. After that,...
In many developed countries, acetaminophen (APAP) overdose-induced acute liver injury is a significant therapeutic problem. Dimethylarginine dimethylaminohydrolase 1 (DDAH1) critical enzyme for asymmetric dimethylarginine (ADMA) metabolism. Growing evidence suggests that dysfunction associated with increased plasma ADMA levels and reduced hepatic DDAH1 activity/expression. The purpose of this study was to investigate the involvement in APAP-mediated hepatotoxicity using Ddah1-/- transgenic...
Non-alcoholic fatty liver disease (NAFLD) is increasingly prevalent and represents a growing challenge in terms of prevention treatment. The aim this study to investigate the protective effects underlying mechanisms vanadium(IV)-chlorodipicolinate ([VIVO(dipic-Cl)(H2O)2, VOdipic-Cl]) mouse model NAFLD induced by high-fat diet (HFD). VOdipic-Cl (10 mg/kg/day body weight) treatment for 4 weeks significantly controlled weight gain, effectively reduced increase serum hepatic triglyceride (TG)...
Diabetic cardiomyopathy (DCM) is a kind of heart disease that affects diabetic patients and one the primary causes death. We previously demonstrated deletion general control nonderepressible 2 (GCN2) kinase ameliorates cardiac dysfunction in mice. The aim this study was to investigate protective effect GCN2iB, GCN2 inhibitor, type (T2D) mice induced by high-fat diet (HFD) plus low-dose streptozotocin (STZ) treatments or leptin receptor (db/db). GCN2iB (3 mg/kg/every other day) treatment for...
It is well recognized that there a strong and complex association between nonalcoholic fatty liver disease (NAFLD) type 2 diabetes (T2D). We previously demonstrated genetic knockout or pharmacological inhibition of general control nondepressible kinase (GCN2), well-known amino acid sensor, alleviated hepatic steatosis insulin resistance in obese mice. However, whether GCN2 affects the development T2D remains unclear. After high-fat diet (HFD) plus low-dose streptozotocin (STZ) treatments,...
<div>Abstract<p>T-cell acute lymphoblastic leukemia (T-ALL) is a type of aggressive with inferior prognosis. Although activating mutations <i>NOTCH1</i> are observed in most T-ALL cases, these alone not sufficient to drive the full development T-ALL. β-Arrestins (ARRB) versatile and multifunctional adapter proteins that regulate diverse cellular functions, including promoting cancer. However, role ARRBs has largely remained elusive. In this study, we showed ARRB1...
<p>Table S1, Suppl. Table1. The characteristics of T-ALL cell lines</p>
<p>Table S4, Supplementary Table 4. RNA-Seq analysis of ARRB1-silenced and overexpression Jurkat cells</p>
<p>Table S2, Supplementary Table2. The characteristics of T-ALL cases</p>
<p>Table S3, Supplementary Table 3. RNA-Seq of T-ALL Clinical Samples</p>
<p>Supplemental methods. Supplementary Figure 1. ARRB1 inhibits the cell proliferation and tumor progression of human T-ALL cells. 2. RNA-Seq expression profile patients aberrant ARRB1in samples lines. 3. promotes degradation ubiquitination ICN1 in Molt4 4. The co-immunoprecipitation (Co-IP) results interaction with E3 ubiquitin ligases Notch1 5. DTX1 is essential for inhibitory effect 6. ARRB1-derived miR-223 sponge BUTR effectively induces apoptosis CCRF-CEM cells.</p>
<p>Table S5 & 6. Supplementary Table 5. Oligocleotide List; Antibody List</p>
<p>Table S1, Suppl. Table1. The characteristics of T-ALL cell lines</p>
<p>Table S2, Supplementary Table2. The characteristics of T-ALL cases</p>
<p>Table S3, Supplementary Table 3. RNA-Seq of T-ALL Clinical Samples</p>