A5015062325- MicroRNA in disease regulation
- RNA regulation and disease
- RNA modifications and cancer
- Neonatal Respiratory Health Research
- Protein Degradation and Inhibitors
- Cancer-related gene regulation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- Medical Imaging and Pathology Studies
- Histone Deacetylase Inhibitors Research
- Mesenchymal stem cell research
- Congenital Diaphragmatic Hernia Studies
- Signaling Pathways in Disease
- Problem and Project Based Learning
- Click Chemistry and Applications
- RNA Research and Splicing
- Biomedical and Engineering Education
- Chromatin Remodeling and Cancer
- Insect Resistance and Genetics
- Acute Lymphoblastic Leukemia research
- Epigenetics and DNA Methylation
- Radiopharmaceutical Chemistry and Applications
- MXene and MAX Phase Materials
- Smoking Behavior and Cessation
Chongqing Medical University
2013-2025
Children's Hospital of Chongqing Medical University
2017-2025
China International Science and Technology Cooperation
2017-2021
The Affiliated Yongchuan Hospital of Chongqing Medical University
2013
Pulmonary fibrosis (PF) is a lethal pathological change of fibrotic interstitial lung diseases (ILDs) with abundant fibroblasts proliferation after severely or continually alveolar epithelial cells (AECs) injury. Barely therapies are helpful for PF. Here we use bleomycin intratracheally injection to model PF without human umbilical cord–mesenchymal stem (hUC–MSCs) and/or nintedanib intervention. RNA‐Seq followed real‐time PCR and western blot were used find out the specific possible...
Abstract T-cell acute lymphoblastic leukemia (T-ALL) is a type of aggressive with inferior prognosis. Although activating mutations NOTCH1 are observed in most T-ALL cases, these alone not sufficient to drive the full development T-ALL. β-Arrestins (ARRB) versatile and multifunctional adapter proteins that regulate diverse cellular functions, including promoting cancer. However, role ARRBs has largely remained elusive. In this study, we showed ARRB1 expressed at low levels assayed clinical...
Pulmonary fibrosis (PF) is a chronic, progressive, and lethal disease with little response to available therapies. One of the major mechanisms PF repeated injury inadequate regeneration alveolar epithelium. In this study, we induced human umbilical cord mesenchymal stem cells (hUC-MSCs) differentiate into type 2 epithelial (AEC2s), provided evidence that intratracheal transplantation hUC-MSC-derived AEC2s (MSC-AEC2s) could improve mortality alleviate in bleomycin-induced mice....
Alveolar epithelial cells (AECs) injury and failed reconstitution of the AECs barrier are both integral to alveolar flooding subsequent pulmonary fibrosis (PF). Nevertheless, exact mechanisms regulating regeneration post-injury still remain unclear. SMARCA4 is a part large ATP-dependent chromatin remodelling complex SWI/SNF, which essential for kidney heart fibrosis. We investigates function in lung by establishing PF mice model with bleomycin firstly found that expression was mainly...
Pulmonary fibrosis is a devastating lung disease without effective treatment options. Sphingosine-1-phosphate receptor 3 (S1pr3), for the lipid signaling molecule sphingosine-1-phosphate, has been shown to mediate development of pulmonary fibrosis, although underlying mechanism not fully understood. Here, we found increased expression S1pr3 in during process bleomycin-induced mice and specific overexpression infiltrated M2 macrophages. We constructed LysM-Cre+/S1pr3flox/flox mice, which was...
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a hereditary disease caused by pathogenic mutations of G6PD. While most the variants G6PD have been annotated, hemolysis unknown etiology but analogous to that in persists, implying existence undocumented variants. In our previous study, we reported four novel China, for which pathogenicity remains be verified.The were verified exogenous expression HEK-293 cells, and their functions predicted PolyPhen-2 SIFT. The CRISPR/Cas9 system was...
<div>Abstract<p>T-cell acute lymphoblastic leukemia (T-ALL) is a type of aggressive with inferior prognosis. Although activating mutations <i>NOTCH1</i> are observed in most T-ALL cases, these alone not sufficient to drive the full development T-ALL. β-Arrestins (ARRB) versatile and multifunctional adapter proteins that regulate diverse cellular functions, including promoting cancer. However, role ARRBs has largely remained elusive. In this study, we showed ARRB1...
<p>Table S1, Suppl. Table1. The characteristics of T-ALL cell lines</p>
<p>Table S4, Supplementary Table 4. RNA-Seq analysis of ARRB1-silenced and overexpression Jurkat cells</p>
<p>Table S2, Supplementary Table2. The characteristics of T-ALL cases</p>
<p>Table S3, Supplementary Table 3. RNA-Seq of T-ALL Clinical Samples</p>
<p>Supplemental methods. Supplementary Figure 1. ARRB1 inhibits the cell proliferation and tumor progression of human T-ALL cells. 2. RNA-Seq expression profile patients aberrant ARRB1in samples lines. 3. promotes degradation ubiquitination ICN1 in Molt4 4. The co-immunoprecipitation (Co-IP) results interaction with E3 ubiquitin ligases Notch1 5. DTX1 is essential for inhibitory effect 6. ARRB1-derived miR-223 sponge BUTR effectively induces apoptosis CCRF-CEM cells.</p>
<p>Table S5 & 6. Supplementary Table 5. Oligocleotide List; Antibody List</p>
<p>Table S1, Suppl. Table1. The characteristics of T-ALL cell lines</p>
<p>Table S2, Supplementary Table2. The characteristics of T-ALL cases</p>
<p>Table S3, Supplementary Table 3. RNA-Seq of T-ALL Clinical Samples</p>
<p>Table S4, Supplementary Table 4. RNA-Seq analysis of ARRB1-silenced and overexpression Jurkat cells</p>
<p>Table S5 & 6. Supplementary Table 5. Oligocleotide List; Antibody List</p>
<p>Supplemental methods. Supplementary Figure 1. ARRB1 inhibits the cell proliferation and tumor progression of human T-ALL cells. 2. RNA-Seq expression profile patients aberrant ARRB1in samples lines. 3. promotes degradation ubiquitination ICN1 in Molt4 4. The co-immunoprecipitation (Co-IP) results interaction with E3 ubiquitin ligases Notch1 5. DTX1 is essential for inhibitory effect 6. ARRB1-derived miR-223 sponge BUTR effectively induces apoptosis CCRF-CEM cells.</p>
<div>Abstract<p>T-cell acute lymphoblastic leukemia (T-ALL) is a type of aggressive with inferior prognosis. Although activating mutations <i>NOTCH1</i> are observed in most T-ALL cases, these alone not sufficient to drive the full development T-ALL. β-Arrestins (ARRB) versatile and multifunctional adapter proteins that regulate diverse cellular functions, including promoting cancer. However, role ARRBs has largely remained elusive. In this study, we showed ARRB1...