A5100449788- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Circular RNAs in diseases
- RNA regulation and disease
- Cancer, Hypoxia, and Metabolism
- Mycobacterium research and diagnosis
- RNA Research and Splicing
- HER2/EGFR in Cancer Research
- Breast Cancer Treatment Studies
- Cancer Research and Treatments
- Cancer, Lipids, and Metabolism
- Lipid metabolism and disorders
- Extracellular vesicles in disease
- Breast Lesions and Carcinomas
- Inflammatory Bowel Disease
- Biomarkers in Disease Mechanisms
- Traditional Chinese Medicine Studies
- Liver Disease Diagnosis and Treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Medicinal Plant Pharmacodynamics Research
- Single-cell and spatial transcriptomics
- Hippo pathway signaling and YAP/TAZ
- Cancer-related Molecular Pathways
- Cancer Treatment and Pharmacology
Guiyang College of Traditional Chinese Medicine
2025
Guizhou University
2025
University of Pennsylvania
2024
Dongguan People’s Hospital
2024
Guangzhou University of Chinese Medicine
2015-2024
Harbin Medical University
2023-2024
Third Affiliated Hospital of Harbin Medical University
2023-2024
Hunan University of Traditional Chinese Medicine
2024
Fujian Medical University
2023-2024
Shanghai Children's Medical Center
2023
This study developed a prognostic model for patients with colon adenocarcinoma (COAD) based on glycosylation-associated genes. By analyzing TCGA-COAD data, 110 key genes were identified, and incorporating five glycosylation-related was constructed. The exhibits good predictive performance is significantly associated clinical features such as age, N stage, M lymph node count. are involved in various biological processes pathways, influence T cell differentiation, may contribute to CRC...
Abstract Objectives: Recently, long noncoding RNAs (lncRNAs) have captured much attention for their important roles in human diseases. Deregulation of lncRNA taurine‐upregulated gene 1 (TUG1) has been reported to regulate cancer progression many types. However, how TUG1 contributes renal cell carcinoma (RCC) remains elusive; we were eager resolve the questions. Methods: Tumor tissues and matched adjacent normal collected from patients with RCC. Messenger RNA (mRNA) levels TUG1,...
MicroRNAs had been proved to be pivotal regulators in nasopharyngeal carcinoma (NPC) by regulating a large amount of genes' expression. In our research, we aim explore the functions miR-9-3p on metastases NPC and figure out potential mechanisms. First, revealed downregulation upregulation fibronectin 1 (FN1), β1 integrin (ITGB1) α5 (ITGAV) expression tissues cells compared with normal using RNA-seq analysis, RT-qPCR, western blot immunohistochemistry. By transfection mimics CNE-1, CNE-2...
A recent study reported that miR-570 was the most important microRNA in gene networks of alcoholic liver disease has potential progressing to hepatocellular carcinoma. However, litter is known regarding expression and specific function progression carcinoma, especially its molecular mechanisms by which exerts functions modulates malignant phenotypes carcinoma cells. Here, we observed highly expressed cell lines (Bel-7404, Huh-7, HepG2), while B7-H1 lowly expressed, compared nonmalignant line...
Background Colorectal cancer (CRC) is one of the most common digestive system tumors worldwide. Hypoxia and immunity are closely related in CRC; however, role hypoxia-immune–related lncRNAs CRC prognosis unknown. Methods Data used current study were sourced from Gene Expression Omnibus The Cancer Genome Atlas (TCGA) databases. patients divided into low- high-hypoxia groups using single-sample gene set enrichment analysis (ssGSEA) algorithm high-immune Estimation STromal Immune cells...
Abstract Background Energy metabolism disorder, especially lipid is an important biological characteristic of colon cancer. This research sought to examine the association between metabolism-related long non-coding RNAs (lncRNAs) and prognoses among cancer patients. Methods The transcriptome profile clinical data patients with were retrieved from Cancer Genome Atlas database. Using consensus clustering, cases divided into two clusters Kaplan–Meier analysis was executed analyze differences in...
Background: Preoperative 5-fluorouracil (5-FU)-based chemoradiotherapy is a standard treatment for locally advanced colorectal cancer (CRC). However, CRC cells often develop chemoradiation resistance (CRR). Recent studies have shown that long non-coding RNA (lncRNA) plays critical roles in myriad of biological processes and human diseases, as well chemotherapy resistance. Since the lncRNAs 5-FU-based CRR remain unknown, they were investigated this study. Materials Methods: A concurrent cell...
Atherosclerosis is the main cause of cardio-cerebrovascular diseases. Endothelial-mesenchymal transition plays an important role in atherosclerosis. Icariin has a protective effect on atherosclerosis; however, underlying mechanism remains unclear. In this study, we explored molecular function icariin oxidized low-density lipoprotein-stimulated human umbilical vein endothelial cells. H19, long non-coding RNA, was identified to be downregulated background lipoprotein-induced...
Maintaining muscle mass is of paramount importance from a clinical perspective as it supports the flexibility, strength, and essential daily tasks that body requires. Furthermore, plays role in regulating body’s metabolic system. Unfortunately, aging can lead to loss mass, which reduce personal independence quality life while increasing risk developing disease. Fibro-adipogenic progenitor cells (FAPs) are muscle-resident for maintaining skeletal fiber size regeneration. These vital FAP...
MiRNA-375 has been reported to play critical roles in a variety of cancers. To unravel its biological roles, especially specific mechanisms action lung squamous cell carcinoma (LUSC), LUSC tissue microarrays and miRNAscope were performed identify the miR-375 expression. Associations with clinicopathologic features, survival, prognostic value clarified retrospective study 90 pairs tissues. In vitro vivo gain- loss-of-function assays conducted validate effects mechanism LUSC. The responsible...
Concurrent radiotherapy and chemotherapy is a widely used, comprehensive treatment for rectal cancer. By studying the impact of concurrent chemoradiotherapy on invasion migration colorectal cancer (CRC) cells researching associated molecular mechanisms, present study aimed to provide novel method improve therapeutic effect this against CRC. Human HCT116 HT29 CRC were simultaneously treated with 4 Gy 6 MV X‑rays 10 µmol/l 5‑fluorouracil establish residual cell model. Transwell experiments...
Bronchopulmonary dysplasia (BPD) is an important cause of respiratory illness in preterm newborns that results significant morbidity and mortality. Hyperoxia a critical factor the pathogenesis BPD, hyperoxia-induced lung injury model has similar pathological manifestations as human BPD. Tetrandrine (Tet) known to suppress oxidative stress, apoptosis inflammation. Thus it been used prevent organ injuries. However, protective effect Tet against newborn rats not reported.A was established using...
BackgroundBreast cancer is the most widespread malignant tumor worldwide. Single-cell sequencing technology offers novel insights and methods to understand onset, progression, treatment of tumors. Nevertheless, there currently an absence a thorough unbiased report on comprehensive research status single-cell in breast cancer. This study seeks summarize quantify dynamics trends by bibliometric analysis.MethodsResearch articles reviews related were selected from WoSCC database. Visualization...
The association between androgen-induced androgen receptor (AR) activating signal and microRNA (miR)-30a was investigated, as well the function of miR-30a in estrogen receptor-negative (ER-), progesterone (PR-), AR-positive (AR+) MDA-MB-453 breast cancer cells. Androgen-induced AR upregulated expression AR, downregulated miR-30a, b c. Bioinformatics analysis indicated a putative c binding site 3'-untranslated region mRNA. It confirmed that gene is direct target whereas does not promoter, may...