A5022032002- Shoulder Injury and Treatment
- Shoulder and Clavicle Injuries
- Enzyme function and inhibition
- Ion channel regulation and function
- Tendon Structure and Treatment
- Sports injuries and prevention
- Knee injuries and reconstruction techniques
- Osteoarthritis Treatment and Mechanisms
- Nerve Injury and Rehabilitation
- Autophagy in Disease and Therapy
- Lower Extremity Biomechanics and Pathologies
- Foot and Ankle Surgery
- Advanced Glycation End Products research
- Musculoskeletal synovial abnormalities and treatments
- Cholinesterase and Neurodegenerative Diseases
- Adenosine and Purinergic Signaling
- Heart Failure Treatment and Management
- Total Knee Arthroplasty Outcomes
- Muscle metabolism and nutrition
- Muscle Physiology and Disorders
- Orthopedic Surgery and Rehabilitation
- Exercise and Physiological Responses
- Cancer-related gene regulation
- Extracellular vesicles in disease
- Nail Diseases and Treatments
Huashan Hospital
2015-2025
Fudan University
2015-2025
Shaanxi Research Association for Women and Family
2012
Tendon injuries are pervasive orthopedic encountered by the general population. Nonetheless, recovery after severe injuries, such as Achilles tendon injury, is limited. Consequently, there a pressing need to devise interventions, including biomaterials, that foster healing. Regrettably, tissue engineering treatments have faced obstacles in crafting appropriate scaffolds and efficacious nanomedical approaches. To surmount these hurdles, an innovative injectable hydrogel (CP@SiO2), comprising...
Discoid lateral meniscus (DLM) is the most common congenital variant of meniscus, which prone to degeneration and lesions, often leads knee osteoarthritis. At present, there no consensus on clinical practice DLM, this expert guidelines DLM was developed approved by Chinese Society Sports Medicine according Delphi method. Among 32 statements drafted, 14 were excluded for redundant information, 18 achieved consensus. This focused definition, epidemiology, etiology, classification,...
ABSTRACT Topical nonsteroidal anti‐inflammatory drugs (NSAIDs) are commonly used to treat sports injuries, but evidence‐based medical guidance for their standardized and rational use is lacking. This guideline working group identified clinically important issues, obtained the full opinions of patients clinical staff, discussed them with expert group. Based on evidence from literature, “clinical practice guidelines topical NSAIDs in treatment injuries” were formulated following methods...
Abstract Mesenchymal stem cells (MSCs) are capable of exerting strong therapeutic potential for the treatment supraspinatus tendon tear. However, MSC therapy remains underutilized and perhaps underrated due to limited evidence dynamic visualization cellular behavior in vivo. Here, second near‐infrared fluorescence imaging with biocompatible PbS quantum dots (QDs) provides a migration map information on biodistribution clearance processes three densities intra‐articularly injected, labeled...
Introduction: Previous studies have shown that obese individuals reduced natriuretic peptide levels.But conflicting data exist on the relation of levels to other metabolic risk factors.Material and methods: We investigated relationship between plasma N-terminal pro-B-type (NT-proBNP) syndrome (MetS) factors in 469 patients free heart failure.Two hundred thirty diagnosed MetS cases 239 non-MetS were included this study.Echocardiography examinations performed left ventricular mass index was...
With the increasingly serious burden of osteoarthritis (OA) on modern society, it is urgent to propose novel diagnostic biomarkers and differentiation models for OA. 7-methylguanosine (m7G), as one most common base modification forms in post transcriptional regulation, through which seventh position N guanine (G) messenger RNA modified by methyl under action methyltransferase; has been found that plays a crucial role different diseases. Therefore, we explored relationship between OA m7G....
Maintaining muscle mass is of paramount importance from a clinical perspective as it supports the flexibility, strength, and essential daily tasks that body requires. Furthermore, plays role in regulating body’s metabolic system. Unfortunately, aging can lead to loss mass, which reduce personal independence quality life while increasing risk developing disease. Fibro-adipogenic progenitor cells (FAPs) are muscle-resident for maintaining skeletal fiber size regeneration. These vital FAP...
To assess whether EGb761 could protect elderly diabetic mice with cognitive disorders and explore the role of beclin-1-mediated autophagy in these protective effects. Two-month-old male db/db−/− wild-type C57/BL6 were randomly divided into six groups: control, 50 mg, 100 (WT) WT mg. (50 mg/kg or bodyweight) was given by gavage once a day for 1 month from age 6 months. Y-maze social choice tests performed at 8th The blood pressure measured. imaging changes brain measured using magnetic...
Background: Monitoring the fatty infiltration (FI) process in rotator cuff muscles is of value establishing a treatment plan and predicting postoperative prognosis. Quantitative T1 mapping shows promise for evaluating muscle degeneration, while its validity monitoring FI progression needs further investigation. Purpose: To determine muscles. Study Design: Controlled laboratory study. Methods: Sprague-Dawley rats (N = 108) underwent left supraspinatus (SS) infraspinatus (IS) tenotomy only...
Rupture of the rotator cuff is a common injury shoulder joint in sports professionals. In addition, research on repair has gained popularity over recent years. Given high rate re-tear after surgery, it necessary to design and prepare biodegradable materials with good mechanical properties, for management condition. Consequently, present study conducted surface modification simvastatin factor-loaded silk fibroin chronic SD rats. The vitro experiments were analyzed through scanning electron...
Abstract Type 2 diabetes mellitus (T2DM) is one of the most common chronic diseases among elderly people. The T2DM increases risk cardio-cerebrovascular disease (CCD), and main pathological change CCD atherosclerosis (AS). Meanwhile, carbonic anhydrases (CAs) are involved in formation progression plaques AS. However, exact physiological mechanism anhydrase III (CAIII) has not been clear yet, there also no correlation study between CAIII protein with CCD. 8-week old diabetic mice (db/db −/−...
Carbonic anhydrase III (CAIII) is remarkably abundant in slow skeletal muscles. It has multiple biological activities which could dissipate or resist some fatigue-related substances. In this study, we purified trans-activating transcriptional activator (TAT) fused CAIII protein and investigated its effect on C2C12 cell apoptosis induced by hypoxia/reoxygenation.The TAT-CAIII genes were constructed, cloned into plasmid pET28a expressed Escherichia coli BL21 (DE3). The fusion proteins with a...
Carbonic anhydrase III (CAIII) is expressed abundantly in slow skeletal muscles, adipocytes, and the liver. It plays a critical role maintaining intracellular pH, antioxidation, energy metabolism, which are further involved fatigue. However, its function mechanism physiological of muscles or antifatigue still ambiguous. We hypothesized that changes CAIII might be related to occurrence muscle After establishing rat soleus fatigue model, we measured protein expression muscles. And biochemical...
To analyze the X-ray and magnetic resonance imaging (MRI) features of acetabular labral tears, so as to improve recognition disease.Imaging 19 patients with tears confirmed by arthroscopy were analyzed retrospectively. All cases examined X-ray. Fourteen underwent MRI examinations.Seventeen had at least one osseous abnormality consistent femoroacetabular impingement (FAI) under arthroscopy; among them 7 cam impingement, 3 pincer mixed impingement. manifestations: 12 FAI; 6 2 4 Five showed...