- Acupuncture Treatment Research Studies
- Electrocatalysts for Energy Conversion
- Advanced Fiber Optic Sensors
- Neuroinflammation and Neurodegeneration Mechanisms
- Photonic and Optical Devices
- Autophagy in Disease and Therapy
- Fuel Cells and Related Materials
- Healthcare and Venom Research
- Advanced Glycation End Products research
- Metabolism, Diabetes, and Cancer
- Neurological Disease Mechanisms and Treatments
- Traditional Chinese Medicine Studies
- Neuroscience and Neuropharmacology Research
- Aldose Reductase and Taurine
- Cardiac Ischemia and Reperfusion
- Pharmacological Receptor Mechanisms and Effects
- Electrochemical Analysis and Applications
- Plasmonic and Surface Plasmon Research
- Nanomaterials for catalytic reactions
- Catalytic Processes in Materials Science
- Biochemical effects in animals
- Peroxisome Proliferator-Activated Receptors
- Advanced Fiber Laser Technologies
- RNA modifications and cancer
- Axon Guidance and Neuronal Signaling
State Key Laboratory of Medical Neurobiology
2009-2024
Fudan University
2012-2024
Huashan Hospital
2021-2023
National Clinical Research
2022-2023
West Anhui University
2021-2023
Shenzhen University
2019-2021
Heilongjiang Academy of Sciences
2021
Ningxia University
2021
Hunan University
2021
University of Vermont
2021
Abstract Atomically ordered intermetallic nanoparticles exhibit improved catalytic activity and durability relative to random alloy counterparts. However, conventional methods with time‐consuming high‐temperature syntheses only have rudimentary capability in controlling the structure of nanoparticles, hindering advances nanocatalysts. We report a template‐directed strategy for rapid synthesis Pd‐based (PdM, M=Pb, Sn Cd) ultrathin porous nanosheets (UPINs) tunable sizes. This uses preformed...
An S-tapered fiber sensor has been realized on the common single-mode by a fusion splicer. The S taper (SFT) can be considered as compact Mach-Zehnder interferometer with total length of hundreds microns. spectral characteristics SFTs different structure parameters including axial offsets and waist diameters have studied. Sensing experiments also carried out to test their response refractive index (RI) strain. SFT an offset 114 μm diameter 54.6 exhibits best combination property. Its RI...
We demonstrate an ultrasensitive temperature sensor based on isopropanol-sealed optical microfiber taper (OMT) in a capillary. The OMT is highly sensitive to ambient refractive index (RI) with maximum sensitivity of 18989 nm/RI unit the range 1.3955-1.4008. thermo-optic effect isopropanol and thermal expansions sealant sealed liquid turn into -3.88 nm/°C 20°C-50°C. contributions from different mechanisms are also investigated theoretically experimentally.
Synthesis of the unconventional phase noble metal nanocrystals may create new opportunities in exploring intriguing physicochemical properties but remains challenging. In research field thin film growth, interface strain offers a general driving force to stabilize metastable epitaxial film. Herein we extend this concept and report solution synthesis face-centered tetragonal Au that has not been discovered before. The successful relies on formation intermetallic AuCu3@Au core–shell structure,...
Stroke causes ischemic brain injury and is a leading cause of neurological disability death. There is, however, no promising therapy to protect the from stress date. Here we show an exciting finding that optimal electroacupuncture (EA) effectively protects injury. The experiments were performed on rats subjected middle cerebral artery occlusion (MCAO) with continuous monitoring blood flow. EA was delivered acupoints "Shuigou" (Du 26) "Baihui" 20) different intensities frequencies optimize...
Summary Aim Hypoxic–ischemic encephalopathy ( HIE ) is a common neurological disease in infants with persistent neurobehavioral impairments. Studies found that neural stem cell NSC therapy benefits rats; however, the mechanisms underlying are still unclear. The current study investigated efficacy and molecular events of human embryonic cells hNSC s) neonatal hypoxic–ischemic HI rats. Methods PKH ‐26‐labeled h s were intranasally delivered to P7 Sprague Dawley rats 24 after . Neurobehavioral...
Diabetes is the most common metabolic disease with many chronic complications, and cognitive disorders are one of complications in patients diabetes. Previous studies have showed that autophagy played important roles progression syndrome, diabetes other diseases. So we investigated whether aged diabetic mice prone to be associated affective Beclin-1-mediated might involved thepahological process.High-fat diet/streptozotocin (STZ) injection-induced C57 were adopted this study. Cognitive...
Tunable synthesis of intermetallic Pd<sub>3</sub>Pb nanowire networks with multiple twin boundaries, a porous structure and advanced N<sub>2</sub> electroreduction performance.
Herein, we successfully fabricated an Al-doped α-Ga2O3 nanorod array on FTO using the hydrothermal and post-annealing processes. To best of our knowledge, it is first time that has been realized via a much simpler cheaper way than based metal-organic chemical vapor deposition, magnetron sputtering, molecular beam epitaxy, pulsed laser deposition. And, self-powered array/FTO photodetector was also as photoanode at 0 V (vs. Ag/AgCl) in photoelectrochemical (PEC) cell, showing peak responsivity...
The fabrication of tilted fiber Bragg gratings (TFBGs) in non-photosensitized single-mode by infrared femtosecond (fs) laser is reported for the first time to best our knowledge. grating structure obtained focusing pulses through a phase mask into positioned sample, which moving along with interference fringe form region covering entire core and partial cladding. A reflective probe based on TFBG gold mirror sputtered one end has been fabricated its maximum refractive index (RI) sensitivity...
δ-opioid receptor (DOR) activation reduced brain ischemic infarction and attenuated neurological deficits, while DOR inhibition aggravated the damage. The underlying mechanisms are, however, not well understood yet. In this work, we asked if protects against injury through a brain-derived neurotrophic factor (BDNF) -TrkB pathway.We exposed adult male Sprague-Dawley rats to focal cerebral ischemia, which was induced by middle artery occlusion (MCAO). agonist TAN-67 (60 nmol), antagonist...
Compact 5-mm-long 100-μm-period long-period fiber gratings (LPFGs) are fabricated by femtosecond laser direct writing. Nearly symmetrical photomodified grating segments located at the center of a core lead to well-defined transmission spectra. The LPFGs can couple guided mode high-order cladding modes second-order diffraction, resulting in high refractive index (RI) sensitivity 5265 nm/RI units RI range 1.433 ~ 1.443 and low-temperature -15.52 pm/°C from 20°C 500°C. latter property is...
We report on the spectral properties of strong coupling between localized surface plasmon resonances (LSPRs) aluminum (Al) nanostructures and tetraphenylporphyrin tetrasulfonic acid hydrate (TPPS) J-aggregates. Because their wide range LSPR bands from ultraviolet to near-infrared wavelengths by controlling structural size, Al nanodisks can realize with different excitons TPPS The Rabi splitting energies based Soret Q are 300 180 meV, respectively. In addition extinction spectrum, we have...
Measurement of the local temperature in transparent materials irradiated by femtosecond laser pulses is important for deep insight into light-matter interaction physics and proper micronanomachining, which is, however, technically challenging. We solve problem this paper using a laser-written fiber Bragg grating that can stably work up to 1000 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">°</sup> C as high-sensitivity sensor monitor thermal...
Abstract Background With the rapidly increasing prevalence of metabolic diseases such as type 2 diabetes mellitus (T2DM), neuronal complications associated with these have resulted in significant burdens on healthcare systems. Meanwhile, effective therapies remained insufficient. A novel fatty acid called S‐9‐PAHSA has been reported to provide benefits T2DM by regulating glucose metabolism. However, whether a neuroprotective effect mouse models remains unclear. Methods This vivo study mice...
Pre-ischemic treadmill training exerts cerebral protection in the prevention of ischemia by alleviating neurotoxicity induced excessive glutamate release following ischemic stroke. However, underlying mechanism this process remains unclear. Cerebral ischemia-reperfusion injury was observed a rat model after 2 weeks pre-ischemic training. Cerebrospinal fluid collected using microdialysis sampling method, and concentration determined every 40 min from beginning to 4 h reperfusion with...
Electroacupuncture (EA) has been shown to increase cerebral blood flow (CBF) and reduce ischemic infarction in the rat model of ischemia (middle artery occlusion, MCAO). Since multiple acupoints are recommended treat ischemia, we performed this study investigate if there is any variation EA protection against with stimulation certain “acupoints” rats. One hour right MCAO an 85% reduction induced extensive (32.9% <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Granulocyte-colony stimulating factor (G-CSF) has been shown to play a neuroprotective role in ischemic stroke by mobilizing bone marrow (BM)-derived endothelial progenitor cells (EPCs), promoting angiogenesis, and inhibiting apoptosis. Impairments mobilization function of the BM-derived EPCs have previously reported animal human studies diabetes where there is both reduction levels its ability promote angiogenesis. This hypothesized account for pathogenesis diabetic vascular complications...
Summary Aims Although cognitive dysfunction is a common neurological complication in elderly patients with diabetes, the mechanisms underlying this relationship remain unclear, and effective preventive interventions have yet to be developed. Thus, study investigated effects of action associated granulocyte colony‐stimulating factor (G‐ CSF ) on diabetic mice cerebral small vessel disease. Methods This included 40 male db/db wild‐type ( WT that were categorized into following four groups at...
The present study was designed to investigate whether the electro-acupuncture (EA) is beneficial extenuate cerebral ischemic injuries following middle artery occlusion (MCAO) in monkey. results indicated that after MCAO. EEG severely inhibited, while recovery slow reperfusion compared with control group. EA, given between acupuncture points Baihui Point (GV. 20) and Renzhong 26) a dense-sparse waveforms,which can be transformed into each other when dense or sparse wave terminated,...
We present novel nanoporous TiO(2)/polyion thin-film-coated long-period fiber grating (LPFG) sensors for the direct measurement of low-molecular-weight chemicals by monitoring resonance wavelength shift. The hybrid overlay films are prepared a simple layer-by-layer deposition approach, which is mainly based on electrostatic interaction TiO(2) nanoparticles and polyions. By alternate immersion LPFG into dispersions polyions, respectively, so-formed thin film exhibits unique internal structure...