A5101444683- Cerebrovascular and Carotid Artery Diseases
- Natural Compound Pharmacology Studies
- Cerebrovascular and genetic disorders
- Acute Ischemic Stroke Management
- Autophagy in Disease and Therapy
- Migraine and Headache Studies
- Ion Transport and Channel Regulation
- Metabolomics and Mass Spectrometry Studies
- Endometrial and Cervical Cancer Treatments
- Phytochemical Studies and Bioactivities
- Parkinson's Disease Mechanisms and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Moyamoya disease diagnosis and treatment
- Cancer-related molecular mechanisms research
- Sulfur Compounds in Biology
- Molecular Biology Techniques and Applications
- Epigenetics and DNA Methylation
- Cervical Cancer and HPV Research
- Natural product bioactivities and synthesis
- Ubiquitin and proteasome pathways
- Cardiovascular Function and Risk Factors
- MicroRNA in disease regulation
- Management of metastatic bone disease
- Cancer Mechanisms and Therapy
- Eicosanoids and Hypertension Pharmacology
Dali University
2022-2025
Anhui University of Traditional Chinese Medicine
2010-2024
China Agricultural University
2020-2024
Southwest University
2023-2024
Jinan University
2022-2024
Hebei Medical University
2022-2024
Zhengzhou University
2024
Xihua University
2023
Ministry of Agriculture and Rural Affairs
2023
State Key Laboratory of Silkworm Genomic Biology
2023
The precuneus/posterior cingulate cortex, which has been associated with pain sensitivity, plays a pivotal role in the default mode network. However, information regarding migraine-related alterations resting-state brain functional connectivity network and local regional spontaneous neuronal activity is not adequate. This study used magnetic resonance imaging to acquire scans 22 migraineurs without aura healthy matched controls. Independent component analysis, data-driven method, was...
Migraine constitute a disorder characterized by recurrent headaches, and have high prevalence, socio-economic burden severe effects on quality of life. Our previous fMRI study demonstrated that some brain regions are functional alterations in migraineurs. As the function human is related to its structure, we further investigated white gray matter structural In current study, used surface-based morphometry, voxel-based morphometry diffusion tensor imaging analyses detect 32 migraineurs...
Schizophrenia (SCZ) is a devastating genetic mental disorder. Identification of the SCZ risk genes in brains helpful to understand this disease. Thus, we first used minimum Redundancy-Maximum Relevance (mRMR) approach integrate genome-wide sequence analysis results on and expression quantitative trait locus (eQTL) data from ten brain tissues identify related SCZ. Second, adopted variance inflation factor regression algorithm their interacting brains. Third, using multiple methods, explored...
Scope (‐)‐Epicatechin (EC) is a natural flavanol monomer found in cocoa, green tea, and variety of other plant foods. In this study, effects EC on blood lipids hepatic steatosis, the underlying mechanisms were investigated. Methods results A hyperlipidemic rat model was induced by high‐fat, high‐cholesterol diet. then administrated to animals gavage at doses 10, 20, 40 mg/kg body weight (BW) for 12 weeks. Simvastatin included as positive control. The showed that significantly reduced total...
Callus browning, a common trait derived from the indica rice cultivar (Oryza sativa L.), is challenge to transformation regeneration. Here, we report map-based cloning of BROWNING OF CALLUS1 (BOC1) using population crossing Teqing, an elite subspecies exhibiting callus and Yuanjiang, wild accession rufipogon Griff.) that less susceptible browning. We show BOC1 encodes SIMILAR TO RADICAL-INDUCED CELL DEATH ONE (SRO) protein. browning can be reduced by appropriate upregulation BOC1, which...
The purpose of this study was to judge the clinical value minimally invasive stereotactic puncture and thrombolysis therapy (MISPTT) for acute intracerebral hemorrhage (ICH). A randomized control trial undertaken. According enrollment criteria, 122 ICH cases were analyzed, which 64 received MISPTT (MISPTT group, MG) 58 conventional craniotomy (CC CG). Glasgow coma scale (GCS) scores, postoperative complications (PC), rebleeding incidences compared. Moreover, 1 year postoperation, long-term...
We previously reported that aquaporin-4 deletion (AQP4-/-) in mice increased edema and altered blood-brain barrier integrity following intracerebral hemorrhage (ICH). To date, little is known about the role of AQP4 apoptosis after ICH. The purpose this study was to examine its mechanisms ICH using AQP4-/- mice. compared survival rate neurological deficits wild-type (AQP4+/+) with those Histological changes were detected terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end...
Background and Purpose: Acute ischemic stroke (AIS) is a serious threat to the life health of middle-aged elderly people. Mechanical thrombectomy offers advantages rapid recanalization, but response patients this treatment varies greatly. This study investigated risk factors for futile recanalization in AIS after through multivariate analyses. Methods: A retrospective was conducted with anterior circulation occlusion from derivation cohort validation who underwent reperfusion defined as...
Gastrointestinal cancers are a major global health challenge, with high mortality rates. This study investigated the anti-cancer activities of 30 monomers extracted from Morus alba L. (mulberry) against gastrointestinal cancers. Toxicological assessments revealed that most compounds, particularly immunotoxicity, exhibit some level toxicity, but it is generally not life-threatening under normal conditions. Among these components, Sanggenol L, Sanggenon C, Kuwanon H,...
Lung cancer is one of the most common types and causes 1.38 million deaths annually, as 2008 worldwide. Identifying natural anti-lung agents has become very important. Gambogenic acid (GNA) active compounds Gamboge, a traditional medicine that was used drastic purgative, emetic, or vermifuge for treating tapeworm. Recently, increasing evidence indicated GNA exerts promising anti-tumor effects; however, underlying mechanism remains unclear. In present paper, we found could induce formation...
Abstract Migraines are a common and undertreated disease often have psychiatric comorbidities; however, the abnormal mechanism of emotional processing in migraine patients has not been well clarified. This study sought to investigate different brain functional activation neutral, positive negative stimuli between healthy subjects. Twenty-six adults with migraines 26 adults, group-matched for sex age, participated this experiment. Although there were no significant differences two groups...
Abstract Background Migraine is a severe and disabling brain disorder, the exact neurological mechanisms remain unclear. Migraineurs have altered pain perception, headache attacks disrupt their sensory information processing sensorimotor integration. The functional connectivity of sub-regions areas with other cortex associated migraine needs further investigation. Methods Forty-eight migraineurs without aura during interictal phase 48 age- sex-matched healthy controls underwent resting-state...
Summary Aims The damage of human brain vascular endothelial cells ( HBVEC s) is the key pathogenesis diabetes‐associated cerebral complications. aim this study was to elucidate effects glutathione GSH ) on free fatty acids FFA s)‐induced s apoptosis, oxidative stress, and involved possible signaling pathway. Methods After culturing for 72 h with s, we determined cell proliferation by CCK 8, detected apoptosis caspase‐3 A nnexin V ‐ FITC / PI staining, judged oxygen stress determining...
Abstract The Arctic fox ( Vulpes lagopus ) is the only species occurring in and has adapted to its extreme climatic conditions. Currently, molecular basis of adaptation climate not been characterized. Here, we applied PacBio sequencing chromosome structure capture technique assemble first V . genome assembly, which assembled into fragments. assembly a total length 2.345 Gb with contig N50 31.848 Mb scaffold 131.537 Mb, consisting 25 pseudochromosomal scaffolds. had approximately 32.33%...
Granulocyte-colony stimulating factor (G-CSF) has been shown to play a neuroprotective role in ischemic stroke by mobilizing bone marrow (BM)-derived endothelial progenitor cells (EPCs), promoting angiogenesis, and inhibiting apoptosis. Impairments mobilization function of the BM-derived EPCs have previously reported animal human studies diabetes where there is both reduction levels its ability promote angiogenesis. This hypothesized account for pathogenesis diabetic vascular complications...
5-Fluorouracil (5-FU) is one of the widely used chemotherapeutic drugs for various cancer treatments, but its chemo-drug resistance a major obstacle in clinical settings. The anticancer effects gambogenic acid (GNA) and potential mechanisms have been well documented past few years. In this study, we determined synergistic inhibitory GNA 5-FU on A549 human lung cells. combined with inhibited viability cells concentration-dependent manner. mitochondrial tolerance two-kind combination treatment...