A5100633024- Reproductive Physiology in Livestock
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Natural product bioactivities and synthesis
- Genomics, phytochemicals, and oxidative stress
- Lipid metabolism and disorders
- Cancer-related molecular mechanisms research
- Acute Ischemic Stroke Management
- NF-κB Signaling Pathways
- Peroxisome Proliferator-Activated Receptors
- Genetic and phenotypic traits in livestock
- Diet, Metabolism, and Disease
- Sirtuins and Resveratrol in Medicine
- Traditional Chinese Medicine Analysis
- Antiplatelet Therapy and Cardiovascular Diseases
- Phytoestrogen effects and research
- Reproductive Biology and Fertility
- Metabolism, Diabetes, and Cancer
- Food Allergy and Anaphylaxis Research
- Ruminant Nutrition and Digestive Physiology
- Diet and metabolism studies
- Adenosine and Purinergic Signaling
- Neurosurgical Procedures and Complications
- RNA regulation and disease
Anhui Agricultural University
2016-2025
Anhui Academy of Agricultural Sciences
2023-2025
Animal Science Research Institute
2023-2024
Xiangtan University
2023
Tianjin University
2022-2023
Suqian University
2021-2022
Huaian First People’s Hospital
2022
Nanjing Medical University
2022
Huaiyin Institute of Technology
2014-2022
Huashan Hospital
2009-2021
In maize (Zea mays), abscisic acid (ABA)-induced H 2 O production activates a 46 kDa mitogen-activated protein kinase (p46MAPK), and the activation of p46MAPK also regulates .However, mechanism for regulation by MAPK in ABA signalling remains to be elucidated.In this study, four reactive oxygen species (ROS)-producing NADPH oxidase (rboh) genes (ZmrbohA-D) were isolated characterized leaves.ABA treatment induced biphasic response (phase I phase II) expression ZmrbohA-D activity oxidase.Phase...
Background: Neuroprotective effects of ketogenic diets (KD) have been reported in stroke models, and nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP3) inflammasome has also implicated the pathogenesis stroke. This study aimed to investigate KD on NLRP3 explore potential molecular mechanisms. Methods: In vivo study, mice were fed with for weeks then subjected middle cerebral artery occlusion/reperfusion (MCAO/R)-injury. vitro SH-SY-5Y cells treated β-hydroxybutyrate (BHB)...
Background/Aims: ß-hydroxybutyrate (BHBA) is the major component of ketone bodies in ketosis. Dairy cows with ketosis often undergo oxidative stress. BHBA related to inflammation involved other diseases dairy cattle. However, whether can induce inflammatory injury cow hepatocytes and potential mechanism this induction are not clear. The NF-κB pathway plays a vital role response. Methods: Therefore, study evaluated stress, pro-inflammatory factors cultured calf treated different...
Summary The aim of this study was to evaluate the oxidative status in ketotic cows. We observed changes and correlations between metabolic non‐ketotic ( n = 10), subclinical 10) cows 10). Plasma samples were analysed by standard biochemical techniques ELISA determine traditional parameters: triglyceride TG ), phosphonium (P), calcium (Ca), aspartate aminotransferase AST alanine ALT alkaline phosphatase ALP total protein TP albumin ALB immune globulin (Ig), cholesterol TC high‐density...
We previously reported that aquaporin-4 deletion (AQP4-/-) in mice increased edema and altered blood-brain barrier integrity following intracerebral hemorrhage (ICH). To date, little is known about the role of AQP4 apoptosis after ICH. The purpose this study was to examine its mechanisms ICH using AQP4-/- mice. compared survival rate neurological deficits wild-type (AQP4+/+) with those Histological changes were detected terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end...
Elevated plasma nonesterified fatty acid (NEFA) levels and hepatocytes damage are characteristics of ketosis in dairy cows. Oxidative stress is associated with the pathogenesis NEFA-induced liver damage. However, exact mechanism by which oxidative mediates apoptosis injury remains poorly understood. The results present study demonstrated that NEFA contribute to reactive oxygen species (ROS) generation, resulting an imbalance between antioxidant species, transcriptional activation p53,...
As the number of patients with cardioembolic ischemic stroke is predicted to be double by 2030, increased burden warfarin-associated hemorrhagic transformation (HT) after cerebral ischemia an expected consequence. However, thus far, no effective treatment strategy available for HT prevention in routine clinical practice. While glucagon-like peptide-1 receptor (GLP-1R) agonist exendin-4 (Ex-4) known protect against oxidative stress and neuronal cell death caused brain damage, its effect on...
Berberine hydrochloride is an isoquinoline type alkaloid extracted from Berberidaceae, Rutaceae, and other plants. Previous reports have shown that berberine has anti‐inflammatory properties. However, the underlying molecular mechanisms remain unclear. In this study, a lipopolysaccharide‐ (LPS‐) induced murine model of mastitis was established to explore action hydrochloride. Sixty mice had been lactating for 5–7 days were randomly divided into six groups, including control, LPS, three...
The aim of the present study was to investigate immunoregulatory effects <em>Astragalus</em> polysaccharide (APS) on RAW264.7 cells. production cytokines by cells analyzed using ELISA, while cell viability and optimal concentration APS were assessed Cell Counting Kit‑8 assay. In addition, mRNA levels IL‑6, inducible nitric oxide synthase (iNOS) TNF‑α determined reverse transcription‑quantitative PCR analysis. co‑stimulatory molecules cell cycle distribution flow...
Diabetes is known to be a main risk factor of post-stroke hemorrhagic transformation following recombinant tissue plasminogen activator (rt-PA) therapy. However, the mechanism through which diabetes exacerbates insufficiently understood. We aimed verify that CD147, extracellular matrix metalloproteinase (MMP) inducer, played vital role in progress.We performed middle cerebral artery occlusion on diabetic and non-diabetic rats, with or without rt-PA treatment, then compared glycosylation...
Glycinin (11S) and β-conglycinin (7S) from soybean (glycine max) cause diarrhea intestinal barrier damage in young animals. Understanding the mechanisms underlying caused by 7S 11S, it is vital to develop strategies eliminate allergenicity. Consequently, we investigated 7S/11S-mediated apoptosis porcine epithelial (IPEC-J2) cells. IPEC-J2 cells suffered endoplasmic reticulum stress (ERS) response activating protein kinase RNA-like ER kinase, transcription factor 6, C/EBP homologous protein,...