A5100737197- Cardiac Ischemia and Reperfusion
- Anesthesia and Neurotoxicity Research
- Cardiac Arrest and Resuscitation
- Melanoma and MAPK Pathways
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Biochemical effects in animals
- Stress Responses and Cortisol
- Neuropeptides and Animal Physiology
- Synthesis and biological activity
- Viral Infections and Vectors
- Tryptophan and brain disorders
- Grief, Bereavement, and Mental Health
- Respiratory Support and Mechanisms
- Circadian rhythm and melatonin
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Mosquito-borne diseases and control
- Neuroendocrine regulation and behavior
- Family and Patient Care in Intensive Care Units
- MicroRNA in disease regulation
- Cancer Mechanisms and Therapy
- S100 Proteins and Annexins
- Computational Drug Discovery Methods
- Alzheimer's disease research and treatments
- Anesthesia and Sedative Agents
Tongji University
2025
Second Hospital of Anhui Medical University
2025
Anhui Medical University
2025
Dali University
2025
First Affiliated Hospital of Nanchang University
2013-2024
Ankang City Central Hospital
2024
Nanchang University
2013-2024
Dalian Medical University
2020-2024
Tohoku University
2021-2024
Shihezi University
2024
Background: The purpose of this study was to characterize the novel sedative/hypnotic agent HSK3486, a 2,6-disubstituted alkylphenol analogue. Methods: mechanism action HSK3486 studied in competitive binding assays and whole-cell patch clamp assays. administered by bolus intravenous injection dogs rats, loss righting reflex as well effects on cardiovascular respiratory systems were assessed. vitro metabolism analyzed CYP450 genotyping enzyme inhibition. Results: competed with...
Background. Japanese encephalitis virus (JEV) is a neurotropic flavivirus that causes (JE), which leads to high fatality rates in human. Tumor necrosis factor alpha (TNF-α) key mediates immunopathology the central nervous system (CNS) during JE. Etanercept safe anti-TNF-α drug has been commonly used treatment of various human autoimmune diseases.
Asiaticoside (AS), a triterpenoid isolated from Centella asiatica, has been found to exhibit antioxidant and anti‐inflammatory activities in several experimental animal models. However, the underlying mechanisms remain elusive. In this study, we provide evidences that AS dose‐dependently inhibited lipopolysaccharide (LPS)‐induced fever inflammatory response, including serum tumor necrosis factor (TNF)‐α interleukin (IL)‐6 production, liver myeloperoxidase (MPO) activity, brain...
Given the significant body of data supporting an essential role for c-jun-N-terminal kinase (JNK) in neurodegenerative disorders, we set out to develop highly selective JNK inhibitors with good cell potency and brain penetration properties. The structure−activity relationships (SAR) around a series aminopyrimidines were evaluated utilizing biochemical cell-based assays measure inhibition mice. Microsomal stability three species, P450 inhibition, generation reactive oxygen species (ROS),...
Activation of the formyl-peptide receptor-like (FPRL) 1 pathway has recently gained high recognition for its significance in therapy inflammatory diseases. Agonism at FPRL1 affords a beneficial effect animal models acute conditions, as well chronic TIPMFVPESTSKLQKFTSWFM-amide (CGEN-855A) is novel 21-amino acid peptide agonist and also activates FPRL2. CGEN-855A was discovered using computational platform designed to predict G protein-coupled receptor agonists cleaved from secreted proteins...
The present study was carried out to investigate the effects and mechanisms of polydatin (PD) in septic mice. model cecal ligation puncture (CLP-)induced sepsis employed. Pretreatment mice with PD (15, 45, 100 mg/kg) dose-dependently reduced sepsis-induced mortality lung injury, as indicated by alleviated pathological changes infiltration proteins leukocytes. In addition, inhibited CLP-induced serum tumor necrosis factor- α (TNF- ) interleukin-6 (IL-6) production, cyclooxygenase-2 (COX-2)...
Background & Aims: The aim of this study was to assess the association between level lactate dehydrogenase (LDH) and severity metabolic syndrome (MetS) Metabolic Associated Fatty Liver Disease (MAFLD) potential diagnostic value LDH for identifying at-risk associated steatohepatitis (MASH). Methods: This cross-sectional, real-world retrospective enrolled a total 1118 obese patients in department bariatric surgery at Second Affiliated Hospital Anhui Medical University from January 1, 2018,...
The advent of large language models has transformed human-robot interaction by enabling robots to execute tasks via natural commands. However, these primarily depend on unimodal data, which limits their ability integrate diverse and essential environmental, physiological, physical data. To address the limitations current dataset problems, this paper investigates novel comprehensive multimodal data collection methodologies can fully capture complexity human in complex real-world kitchen...
Lidocaine is a commonly used local anesthetic, and low-dose lidocaine has neuroprotective effects on cerebral ischemia/reperfusion (CI/R) injury; the mechanism for this, however, still unclear. The aim of this study was to investigate role possible mechanisms CI/R injury in rats.We constructed rat (male Sprague-Dawley rats, 6-8 weeks old) model induced by middle artery occlusion (MCAO). Histopathology, neuronal apoptosis, oxidative stress, inflammatory response were evaluated using...
Novel influenza A viruses of avian-origin may be the precursors pandemic strains. This descriptive study aims to introduce a novel (H10N8) virus which can infect humans and cause severe diseases.Collecting clinical data three cases human infection with reassortment avian in Nanchang, Jiangxi Province, China.Three new A(H10N8) were described, two fatal cases, one was case. These presented pneumonia that progressed acute respiratory distress syndrome (ARDS) intractable failure.This China...
A prolonged stay in the intensive care unit (ICU) is associated with gastrointestinal failure, which may have a destructive effect on functional status within 1 year after hospital discharge. The aim was to investigate effects of daily exercise session, using bedside cycle ergometer, functions, such as diarrhea, gastric retention, and vomiting, patients severe pneumonia who received mechanical ventilation (MV). study randomized controlled trial, its setting ICU tertiary Eastern China. total...
The present study examined whether perceptions of a transgressor's trustworthiness mediates the relationship between apologies and repaired trust, moderating role negative emotions within this process. Chinese undergraduate students (N= 221) completed trust game where they invested tokens in their counterpart, either experienced no violation (i.e., half returned), or followed by an apology. Participant's behavior was measured number re-invested counterpart second round game. Participants...