A5051597031- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Pharmacological Effects of Natural Compounds
- Computational Drug Discovery Methods
- Respiratory and Cough-Related Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Synthesis of Organic Compounds
- Lipid metabolism and disorders
- Autophagy in Disease and Therapy
- Ferroptosis and cancer prognosis
- Natural product bioactivities and synthesis
- Diet, Metabolism, and Disease
- Gut microbiota and health
- Advanced Glycation End Products research
- Traditional Chinese Medicine Analysis
- Epigenetics and DNA Methylation
- Quinazolinone synthesis and applications
- RNA Research and Splicing
- Natural Antidiabetic Agents Studies
- Herbal Medicine Research Studies
- Plant biochemistry and biosynthesis
- Microbial Metabolism and Applications
- Synthesis and Biological Evaluation
Chengdu University of Traditional Chinese Medicine
2020-2025
Kunming Medical University
2022-2024
Shenyang Medical College
2023
Integrated Chinese Medicine (China)
2023
Abstract Prunella vulgaris L, a perennial herb widely used in Asia the treatment of various diseases including cancer. In vitro studies have demonstrated therapeutic effect L. against breast cancer through multiple pathways. However, nature biological mechanisms remains unclear. this study, Network pharmacology based approach was to explore active constituents and potential molecular for The methods adopted included prescreening, target prediction, GO KEGG pathway enrichment analysis....
Irinotecan (CPT-11) is a chemotherapy agent commonly used for the treatment of gastrointestinal tumors, with diarrhea being frequent adverse effect. Hesperidin flavonoid abundant in citrus fruits and has shown potential managing CPT-11-induced (CID). However, mechanisms underlying its effects remain unclear. This study established mouse model CID using CPT-11 administration to evaluate hesperidin on severity, intestinal pathology, gut microbiota composition, metabolite profiles by conducting...
Background Colorectal cancer (CRC) is one of the most common digestive system tumors worldwide. Hypoxia and immunity are closely related in CRC; however, role hypoxia-immune–related lncRNAs CRC prognosis unknown. Methods Data used current study were sourced from Gene Expression Omnibus The Cancer Genome Atlas (TCGA) databases. patients divided into low- high-hypoxia groups using single-sample gene set enrichment analysis (ssGSEA) algorithm high-immune Estimation STromal Immune cells...
Background: Ferroptosis, an iron-dependent form of cell death, plays a crucial role in the progression various cancers, including colon adenocarcinoma (COAD). However, multi-omics signatures relevant to ferroptosis regulation COAD diagnosis remain be elucidated. Methods: The transcriptomic, miRNAomic, and methylomic profiles patients were acquired from Cancer Genome Atlas (TCGA). Ferroptosis activity these was determined, represented by score (FS), using single-sample gene set enrichment...
Nonalcoholic steatohepatitis (NASH), a progression of nonalcoholic fatty liver disease (NAFLD), is clinical syndrome characterized by steatosis, inflammation, and hepatocellular damage. Ganlu powder (GLP) classic traditional Chinese medicine prescription that has shown favorable treatment effects on NASH. However, the underlying therapeutic mechanisms are still poorly understood. This study aimed at exploring potential mechanism GLP in NASH via network pharmacology molecular docking. PubMed...
Background: Atherosclerosis (AS) is an immunoinflammatory disease associated with dyslipidemia. Zhuyu Pill (ZYP) a classic Chinese herbal compound that has been shown to exhibit anti-inflammatory and lipid-lowering effects on AS in our previous studies. However, the underlying mechanisms by which ZYP ameliorates atherosclerosis have not yet fully investigated. In this study, network pharmacology vivo experiments were conducted explore pharmacological of ameliorating AS. Methods: The active...
<title>Abstract</title> Genome-wide association studies (GWAS) meta-analysis have unveiled common single nucleotide polymorphisms (SNPs) associated with the increased risk of Non-alcoholic fatty liver disease (NAFLD). We conducted a phenome-wide study (PheWAS) using data from UK Biobank to further elucidate NAFLD-associated phenotypes and investigate disease's underlying biology. A significant enrichment was found in 31 778 traits examined 17 known NAFLD-risk SNPs along 4:1 matched control...