A5080648360- Atmospheric chemistry and aerosols
- Air Quality and Health Impacts
- Air Quality Monitoring and Forecasting
- Atmospheric Ozone and Climate
- Toxic Organic Pollutants Impact
- Fullerene Chemistry and Applications
- Vehicle emissions and performance
- Atmospheric aerosols and clouds
- MicroRNA in disease regulation
- Neuroscience and Neuropharmacology Research
- Graphene research and applications
- Boron and Carbon Nanomaterials Research
- Porphyrin and Phthalocyanine Chemistry
- Advanced Chemical Physics Studies
- Circular RNAs in diseases
- Climate variability and models
- Cancer-related molecular mechanisms research
- Effects and risks of endocrine disrupting chemicals
- Advanced biosensing and bioanalysis techniques
- Neurogenesis and neuroplasticity mechanisms
- Diamond and Carbon-based Materials Research
- Carbon Nanotubes in Composites
- Synthesis and Properties of Aromatic Compounds
- RNA modifications and cancer
- Liver Disease Diagnosis and Treatment
Union Hospital
2025
Huazhong University of Science and Technology
2025
Wuhan Union Hospital
2025
Chinese Research Academy of Environmental Sciences
2018-2025
Shandong Academy of Agricultural Sciences
2022-2025
Tianjin University of Science and Technology
2025
Shandong University
2015-2024
Beijing National Laboratory for Molecular Sciences
2019-2024
Peking University
2010-2024
Sichuan Agricultural University
2024
Nitro-PAHs are globally worrisome air pollutants because their high direct-acting mutagenicity and carcinogenicity. A mechanistic understanding of formation is crucial importance for successful prevention atmospheric pollution. Here, the nitro-PAHs arising from OH-initiated NO3-initiated reactions PAHs was investigated by using quantum chemical calculations. It widely assumed that OH or NO3 radicals attack on C atoms aromatic rings in PAH molecule, followed addition NO2 to OH–PAH NO3–PAH...
Abstract Prunella vulgaris L, a perennial herb widely used in Asia the treatment of various diseases including cancer. In vitro studies have demonstrated therapeutic effect L. against breast cancer through multiple pathways. However, nature biological mechanisms remains unclear. this study, Network pharmacology based approach was to explore active constituents and potential molecular for The methods adopted included prescreening, target prediction, GO KEGG pathway enrichment analysis....
Harmful algal blooms are a major type of marine disaster that endangers the ecological environment and human health. Since bloom is complex nonlinear process with time characteristics, traditional statistical methods often cannot provide good predictions. In this paper, we propose method based on machine learning aim to predict occurrence by environmental parameters. The features related growth have been experimented for achieving prediction concentrations combination strategy. We validate...
Depression is a neuropsychiatric disease associated with neuronal anomalies within specific brain regions. In the present study, we screened microRNA (miRNA) expression profiles in dentate gyrus (DG) of hippocampus and found that miR-26a-3p was markedly downregulated rat model depression, whereas upregulation DG regions rescued deterioration depression-like phenotypes resulting from stress exposure, effects appear to be mediated by PTEN pathway. The knockdown normal control rats induced...
The ambient levels of NO2 in urban areas China recent years have generally shown a downward trend, but high concentrations still exist under certain conditions, and the causes for such phenomenon its impact on air quality remain unclear. Taking Dongying, typical petrochemical city Bohai Bay China, as an example, this paper analyzed influence investigated formation with concentrations. results indicated that higher daily (>40 μg/m3) mainly occurred during January-April September-December...
Abstract. The chlorine atom (Cl·) has a high potential to perturb atmospheric photochemistry by oxidizing volatile organic compounds (VOCs), but the exact role it plays in polluted troposphere remains unclear. Master Chemical Mechanism (MCM) is near-explicit mechanism that been widely applied chemistry research. While addresses comprehensively initiated OH, O3 and NO3 radicals, its representation of Cl· incomplete as only considers reactions for alkanes. In this paper, we develop more...
Abstract The hepatokine follistatin is elevated in patients with type 2 diabetes (T2D) and promotes hyperglycemia mice. Here we explore the relationship of plasma levels incident T2D mechanisms involved. Adjusted hazard ratio (HR) per standard deviation (SD) increase for 1.24 (CI: 1.04–1.47, p < 0.05) during 19-year follow-up ( n = 4060, Sweden); 1.31 1.09–1.58, 0.01) 4-year 883, Finland). High circulating associates adipose tissue insulin resistance non-alcoholic fatty liver disease 210,...
Chronic pain is often associated with cognitive decline, which could influence the quality of patient's life. Recent studies have suggested that Toll-like receptor 3 (TLR3) crucial for memory and learning. Nonetheless, contribution TLR3 to pathogenesis decline after chronic remains unclear. The level in hippocampal neurons increased constriction injury (CCI) group than sham this study. Importantly, compared wild-type (WT) mice, knockout (KO) mice TLR3-specific neuronal knockdown both...
In order to investigate the causes of complex air pollution in coastal cities Bohai Rim China, a one-month intensive field observation combined with model simulation was carried out typical city named Dongying September 2022. The results showed that two PM2.5 and O3 episodes occurred period, primary pollutant being O3. Atmospheric photochemical reactions occurring under unfavorable meteorological conditions led production while at same time facilitating generation nitrate, sulfate, other...
This study focuses on the homogeneous gas-phase formation of polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) from 2,4,6-trichlorophenol (2,4,6-TCP) 2,4-dichlorophenol (2,4-DCP) precursors, which were found both in gas phase fly ash samples as dominating chlorophenol congeners municipal waste incinerators (MWIs). Molecular orbital theory calculations have been performed for mechanism. The geometrical parameters vibrational frequencies all stationary points calculated at...
Vascular smooth muscle cells (VSMCs) can switch between differentiated and dedifferentiated phenotypes, this phenotype is believed to be essential for repair of vascular injury. We studied the inhibitory effect 22 alpha (SM22 alpha) on VSMC proliferation in vitro vivo explored potential molecular mechanisms effect.By using coimmunoprecipitation glutathione S-transferase pull-down assays, we have shown that SM22 binds Ras alpha-overexpressed VSMCs presence or absence platelet-derived growth...