A5010679752- 3D Printing in Biomedical Research
- Cancer, Hypoxia, and Metabolism
- Protein Kinase Regulation and GTPase Signaling
- Innovative Microfluidic and Catalytic Techniques Innovation
- Pancreatic and Hepatic Oncology Research
- Electrohydrodynamics and Fluid Dynamics
- Genetics, Aging, and Longevity in Model Organisms
- Microfluidic and Capillary Electrophoresis Applications
- Allergic Rhinitis and Sensitization
- Pancreatic function and diabetes
- Cancer Cells and Metastasis
- Biomarkers in Disease Mechanisms
- Protein Hydrolysis and Bioactive Peptides
- Renal and related cancers
- Asthma and respiratory diseases
- Antimicrobial Peptides and Activities
- Neuroblastoma Research and Treatments
- Estrogen and related hormone effects
- Mitochondrial Function and Pathology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Sirtuins and Resveratrol in Medicine
- Heavy Metal Exposure and Toxicity
- Peptidase Inhibition and Analysis
- Microfluidic and Bio-sensing Technologies
- Pregnancy and Medication Impact
Nanjing Drum Tower Hospital
2021-2025
Southeast University
2024
Shandong Normal University
2015-2017
Abstract Chemotherapy is an essential postoperative treatment for pancreatic cancer, while due to the lack of effective drug evaluation platforms, therapeutic outcomes are hampered by tumor heterogeneity among individuals. Here, a novel microfluidic encapsulated and integrated primary cancer cells platform proposed biomimetic 3D cultivation clinical evaluation. These into hydrogel microcapsules carboxymethyl cellulose cores alginate shells based on electrospray technique. Benefiting from...
Resveratrol is a natural polyphenol derived mainly from the skin of grapes and red wine. prolongs life span in several invertebrates, but this function not found mice. Our recently published paper demonstrated that resveratrol prolonged longevity annual fish Nothobranchius guentheri, promising vertebrate model for anti-aging research. However, process by remains largely unexplored, little known about its effects on oxidative stress. In study, long-term supplementation sexual maturity onward...
Abstract Drug therapies are the cornerstone of systemic treatment for pancreatic cancer patients. However, relative outcome drug evaluation is often hampered by complex microenvironment due to lack reasonable tumor models. Here, we proposed a novel platform that integrated adenocarcinoma cells encapsulated into hydrogel microcapsules three‐dimensional (3D) cultivation and antitumor agent evaluation. These contain alginate/poly ( N ‐isopropyl acrylamide) (alginate/PNIPAM) shells carboxymethyl...
Investigation of patient-derived primary tissues is great importance in the biomedical field, but recent tissue slicing and cultivation techniques still have difficulties satisfying clinical requirements. Here, we propose a controllable histotomy strategy that utilizes hierarchical magnetic microneedle array robots to tailor establish desired high-throughput tissue-on-a-chip. This was performed using three-dimensional printed, mortise-tenon-structured device coupled with...
Background: RhoGTPase-activating proteins (RhoGAPs) regulate RhoGTPases in cells, but whether individual reactive oxygen species (ROS) RhoGAPs is unknown.Our previous published papers have shown that deleted liver cancer 1 (DLC1) inhibits cell migration by its RhoGAP activity.The present study was designed to explore the role of H 2 O regulation DLC1.Materials and Methods: We treated cells with for 24h phenotypic changes were analyzed MTT, RT-PCR, Western blotting, immunofluorescence...
Abstract Objectives ZFP91, an E3 ligase, has been reported to possess cancer‐promoting functions. This study aimed elucidate the exact role of ZFP91 in tumour progression pancreatic cancer and underlying mechanisms. Materials Methods We analysed correlation between expression through TCGA GEO data sets. Growth curve, colony formation, wound healing transwell invasion assays were conducted evaluate proliferation, migration lentivirus transfected cells. GSEA Western blot analysis performed...
Asthma, a chronic respiratory disease closely associated with inflammation, presents ongoing treatment challenges. IALLIPF (le-Ala-Leu-Leu-Ile-Pro-Phe) is one of millet prolamins peptides (MPP) which shows anti-oxidant bioactivity by reducing the production reactive oxygen species (ROS). Tryptophan (Trp, W) an amino acid that has been demonstrated to possess anti-inflammatory effects. We introduce novel cathepsin B-activatable bioactive nanocarrier, PEG-IALLIPF-GFLG-W (MPP-Trp), designed for...
Abstract Objective To explore the cross-sectional relationship between exposure to Environmental Endocrine Disruptors (EEDs) and Henoch-Schoenlein Purpura Nephritis (HSPN) risk in Children. Methods This was a retrospective case-control study of 31 pediatric patients with diagnosed HSPN 30 normal children through routine physical examination. All Participants' basic characteristics, clinical indicators were collected from January 2020 December 2023 at our centers. Residues related endocrine...