A5100622033- RNA Research and Splicing
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- MicroRNA in disease regulation
- Antimicrobial Resistance in Staphylococcus
- Bacterial Genetics and Biotechnology
- Liver Disease Diagnosis and Treatment
- Escherichia coli research studies
- Genomics and Phylogenetic Studies
- Cancer-related molecular mechanisms research
- CRISPR and Genetic Engineering
- Hepatitis C virus research
- Toxin Mechanisms and Immunotoxins
- Single-cell and spatial transcriptomics
- SARS-CoV-2 and COVID-19 Research
- Endoplasmic Reticulum Stress and Disease
- Hepatitis B Virus Studies
- interferon and immune responses
- Cancer-related gene regulation
- Bacteriophages and microbial interactions
- Genomics and Chromatin Dynamics
- Viral gastroenteritis research and epidemiology
- Aquaculture disease management and microbiota
- Cellular transport and secretion
- Neuroscience and Neuropharmacology Research
Dalian Medical University
2007-2025
University of Calgary
2019-2024
Alberta Children's Hospital
2019-2024
Alberta Children's Hospital Research Institute
2020-2024
Taian City Central Hospital
2023-2024
Air Force Medical University
2024
Tibet University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Guang’anmen Hospital
2024
Qingdao University
2023-2024
Background Autoimmune thyroid disease (AITD) ranks among the most prevalent diseases, with inflammatory cytokines playing a decisive role in its pathophysiological process. However, causal relationship between and AITD remains elusive. Methods A two-sample Mendelian randomization (MR) analysis was performed to elucidate connection 41 cytokines. Genetic variations associated were sourced from FinnGen biobank, whereas comprehensive meta-analysis of genome-wide association studies (GWASs)...
To investigate why the level of Lyn is significantly decreased in B cells from a majority patients with systemic lupus erythematosus (SLE) and to determine role microRNA-30a (miR-30a) SLE cell hyperactivity.Luciferase reporter gene assays were performed identify interaction between miR-30a 3'-untranslated region (3'-UTR) Lyn. Levels determined by TaqMan quantitative polymerase chain reaction (qPCR), messenger RNA levels tested real-time qPCR, protein using Western blotting. The quantity IgG...
The Hfq protein is reported to be an RNA chaperone, which involved in the stress response and virulence of several pathogens. In E. coli, can mediate interaction between some sRNAs their target mRNAs. But it controversial whether plays important role S. aureus. this study, we found that deletion hfq gene aureus 8325-4 increase surface carotenoid pigments. mutant was more resistant oxidative but pathogenicity reduced. We reveal detected only strains. Using microarray qRT-PCR, identified 116...
Valosin containing protein (VCP)/p97 plays various important roles in cells. Moreover, elevated expression of VCP hepatocellular carcinoma (HCC) is correlated with increased incidence recurrence. But the role HCC progression vitro and vivo unclear. And there are few reports about regulation mechanism on HCC. In this study, it was identified that level frequently human tissues. addition, down-regulation siRNAs could dramatically suppress genesis tumor vivo. It found miR-129-5p directly...
A progressive increase in MECP2 protein levels is a crucial and precisely regulated event during neurodevelopment, but the underlying mechanism unclear. We report that post-transcriptionally vitro differentiation of human embryonic stem cells (hESCs) into cortical neurons. Using reporters to identify functional RNA sequences 3′ UTR genetic manipulations explore role interacting factors on endogenous MECP2, we discover combinatorial mechanisms regulate stability translation. The RNA-binding...
Alzheimer's disease (AD) is an age-related neurodegenerative characterized by the deposition of amyloid-β (Aβ) peptides and neurofibrillary tangles (NFTs) massive loss neuronal cells in brain. Adult hippocampus continuously generates new neurons throughout life to shape brain function impaired neurogenesis may contribute a series cognitive deterioration associated with AD. Enhancing endogenous represents promising strategy that ameliorate AD-associated defects. However,...
Here, we have asked about post-transcriptional mechanisms regulating murine developmental neurogenesis, focusing upon the RNA-binding proteins Smaug2 and Nanos1. We identify, in embryonic neural precursors of cortex, a protein/ nanos1 mRNA complex that is present cytoplasmic granules with translational repression Dcp1 4E-T. show inhibits Nanos1 promotes knockdown enhancing neurogenesis depleting precursors, inhibiting maintaining precursors. Moreover, likely regulates by silencing mRNA....
Maternal diabetes is known to adversely influence brain development in offspring. Here, we provide evidence that this involves the circulating metabolite methylglyoxal, which increased diabetes, and its detoxifying enzyme, glyoxalase 1 (Glo1), when mutated associated with neurodevelopmental disorders. Specifically, Glo1 levels were decreased embryonic mouse cortical neural precursor cells (NPCs), led premature neurogenesis NPC depletion embryonically long-term alterations neurons...
The development of the cerebral cortex requires balanced expansion and differentiation neural stem/progenitor cells (NPCs), which rely on precise regulation gene expression. Because NPCs often exhibit transcriptional priming cell-fate-determination genes, ultimate output these genes for fate decisions must be carefully controlled in a timely fashion at post-transcriptional level, but how that is achieved poorly understood. Here, we report de novo missense variants an RNA-binding protein...
This study aims to analyze the effects of temporal SARS-CoV-2 antibodies in China before and after both vaccination natural infection, thereby providing an empirical basis for evaluating effectiveness various prevention methods, including vaccination. IgG against were determined using chemiluminescence immunoassays, antibody data was collected from published articles starting early 2020 patients scheduled surgery at Hospital Dalian Medical University between January 2022 2024. A infection...
An anatomically accurate 3-dimensional numerical model of the right rat nasal cavity was developed and used to compute low, medium, high flow rate inspiratory expiratory mucosal odorant uptake (imposed patterning) for 3 odorants with different mucus solubilities. The computed surface mass flux distributions were compared anatomic receptor gene expression zones identified in literature. In general, simulations predicted that highly soluble absorbed dorsally medially, corresponding roughly...
Staphylococcus aureus is a gram-positive pathogen responsible for wide variety of diseases. RNAIII the key effector accessory gene regulator (agr) system. It regulatory RNA (514 nucleotides long) that acts at both transcription and translation level to regulate production numerous toxins, enzymes cell surface proteins. Here, we reveal map (major histocompatibility complex class II analogous protein) positively regulated by RNAIII. Our further study indicates 108–135 nt fragment as an...
MicroRNAs have been implicated in the regulation of gene expression various biological processes a post-transcriptional manner under physiological and pathological conditions including host responses to viral infections. The 2009 pandemic H1N1 influenza virus is an emerging reassortant strain swine, human bird that can cause mild severe illness even death. To further understand molecular pathogenesis virus, we profiled cellular microRNAs lungs from BALB/c mice infected with wild-type...
Abstract Gene regulation and metabolism are two fundamental processes that coordinate the self-renewal differentiation of neural precursor cells (NPCs) in developing mammalian brain. However, little is known about how metabolic signals instruct gene expression to control NPC homeostasis. Here, we show methylglyoxal, a glycolytic intermediate metabolite, modulates Notch signalling regulate fate decision. We find increased methylglyoxal suppresses translation Notch1 receptor mRNA mouse human...
As the largest peripheral lymphoid organ in poultry, spleen plays an essential role regulating body’s immune capacity. However, compared with chickens and ducks, information about age- breed-related changes goose remains scarce. In this study, we systematically analyzed age-dependent morphological, histological, transcriptomic characteristics between Landes (LG; Anser anser ) Sichuan White (SWG; cygnoides ). The results showed a gradual increase splenic weights for both LG SWG until week 10,...