A5103074766- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Pediatric health and respiratory diseases
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Cancer-related molecular mechanisms research
- Flavonoids in Medical Research
- Medicinal Plant Pharmacodynamics Research
- Cytokine Signaling Pathways and Interactions
- Immune Cell Function and Interaction
- Health, psychology, and well-being
- Natural product bioactivities and synthesis
- Lung Cancer Diagnosis and Treatment
- Respiratory and Cough-Related Research
- Chemokine receptors and signaling
- IL-33, ST2, and ILC Pathways
- Inflammation biomarkers and pathways
- Cancer Mechanisms and Therapy
- Immune Response and Inflammation
- Dermatology and Skin Diseases
- Polyamine Metabolism and Applications
- Inflammasome and immune disorders
- Thermal Regulation in Medicine
- Genomics, phytochemicals, and oxidative stress
- Garlic and Onion Studies
Huashan Hospital
2014-2024
Fudan University
2014-2024
Xi'an Jiaotong University
2024
Novem (Netherlands)
2010
Wan Fang Hospital
2010
The objective of the present study was to investigate therapeutic efficacy flavonoid components in Scutellaria baicalensis on proliferation, metastasis and lung cancer-associated inflammation during nicotine induction A549 H1299 cancer cell lines. After experimental period, augmentation proliferation observed, accompanied by marked decrease apoptotic cells nicotine-induced cells; additionally, nicotine-exposed exhibited increased invasive migratory abilities based invasion wound-healing...
Cholesterol is a nutrient commonly found in the human diet. The relationship between dietary cholesterol, its sources, and cardiovascular disease (CVD) still topic of debate. This study aimed to investigate association events Chinese population. present analyzed data from China Health Nutrition Survey (CHNS) cohort 1991 2015. 3903 participants who were 40 years age or older at baseline had no history disease, diabetes, hypertension. During median follow-up 14 years, 503 identified through...
Excessive corticosterone (CORT) is acknowledged to induce neuronal damage in a number of regions the brain, particularly hippocampus, main area implicated depression. However, little research has been conducted on alterations hypothalamic neurons depression and cellular molecular basis for these changes. In present study, we aimed determine whether CORT causes apoptosis primary cultured neurons, investigate protective effects icariin, an active natural ingredient from Chinese plant,...
Background. Studies that looked at asthma airway remodeling pathogenesis and prevention have led to the discovery of rat sarcoma viral oncogene (RAS) signaling pathway as a key mechanism controls smooth muscle cell (ASMC) proliferation. Baicalin has great anti-inflammatory, proliferation-inhibited, respiratory disease-relieving properties. However, inhibitory effects mechanisms baicalin on ASMC-mediated in mice are still poorly understood. Methods. After establishing asthmatic model by...
Objective The study aims to evaluate the efficacy and safety of two Chinese herbal formulae for treatment stable COPD. Methods A multicenter, double-blind, double-dummy, randomized controlled trial (RCT) was conducted. All groups were treated with additional conventional medicines. There a 6-month 12-month follow-up 5 times. Primary outcomes included lung function test, exacerbation frequency, score SGRQ. Second consisted 6MWD, BODE index, psychological field score, inflammatory factors...
Cycloastragenol (CAG), a secondary metabolite from the roots of Astragalus zahlbruckneri, has been reported to exert anti‑inflammatory effects in heart, skin and liver diseases. However, its role asthma remains unclear. The present study aimed investigate effect CAG on airway inflammation an ovalbumin (OVA)‑induced mouse model. current evaluated lung function levels autophagy via measurement hyperresponsiveness (AHR), histology examination, inflammatory cytokine western blotting, amongst...
Background It has already been recognized that psychosocial stress evokes asthma exacerbation; however, the mechanism of how gets inside body is not clear. This study aimed to observe impact on airway inflammation and its in ovalbumin-induced asthmatic mice combined with social disruption stress. Methods Thirty-six male BALB/c were randomly divided into: control group, group (ovalbumin-induced), plus (SDR), SDR group. The open field video tracking system was used assess animal behaviors....
Chronic obstructive pulmonary disease (COPD) is a common respiratory characterized by irreversible airflow limitation. The current medications show limited effects on the decline of function in COPD. Our multicenter clinical trial found that Bu-Shen-Fang-Chuan fomula (BSFCF), Chinese herbal formula, markedly reduced frequencies acute exacerbation COPD and delayed lung decline. However, underlying mechanisms are still unclear. In this study, we established rat model through 6-month exposure...
Background . The theories of Shen‐reinforcement and Qi‐supplementation are important in asthma treatment based on traditional Chinese medicine theories. Early studies suggested that Invigorating Kidney Supplementing Qi herbal formulae, Bu Shen Fang Chuan (BSFC) Yi (BSYQ), conveyed promising results treatment. However, the efficacy safety formulae need to be further investigated by a randomized double‐blind clinical trial. Methods 328 eligible patients were randomly sent BSFC, BSYQ, placebo...
Abstract Background Mast cells play important roles in the progression of various malignancies, but their prognostic value gastric cancer is unknown. Tryptase expression, as an indicator mast cell activity, was therefore evaluated to see whether this could be incorporated usefully into a nomogram after surgery patients with cancer. Methods Tissue microarrays from were created formalin-fixed, paraffin-embedded resection specimens. density assessed by immunohistochemistry, and association...
Objective. To investigate the features of airway inflammation and hypothalamic-pituitary-adrenal axis (HPAA) activity in patients with asthma accompanied by depression. Methods. Adult asthmatics were recruited enrolled into one two groups based on scores Hamilton Depression Rating Scale (HAMD): depression (HAMD score ≥8, n = 23), without <8, 41). In addition, 27 healthy individuals 21 adults only as controls. Induced sputum blood samples collected for measurement cytokines other inflammatory...
Growing evidence suggests that long non-coding RNAs (lncRNAs) play a key role in the pathogenesis of asthma. Although some differentially expressed lncRNAs have been identified asthmatic patients, many asthma-related not annotated. In present study, six patients and three healthy subjects were randomly selected from 34 17 subjects. Second-generation high-throughput sequencing was performed on their peripheral blood samples. There 1137 asthma compared to controls, which 485 upregulated 652...
Objective: To investigate serum and sputum cytokine profiles in asthma chronic obstructive pulmonary disorder (COPD). Methods: Clinical characteristics, blood samples were collected from (n = 37) COPD 36) patients, healthy subjects 39). Cytokines measured by enzyme-linked immunosorbent assay (ELISA) inflammation antibody array; levels analysed according to smoking status presence of eosinophilia the airways COPD/asthma compared with those subjects. Results: ELISA revealed a significant...
The purpose of this study was to evaluate the efficacy and safety Uyghur medical formula Loki zupa in patients with chronic asthma. Adult asthma randomly received placebo or as add-on inhaled corticosteroids (ICS) maintenance treatment. mimics administered orally 10ml per time, three times a day for 8 weeks. primary endpoints were control test (ACT) score peak expiratory flow (PEF). secondary acute exacerbation rate, lung function, night waking days symptom-free near two weeks, quality life...
Abstract Background Inhaled glucocorticoid corticosteroid (ICS), long-acting β2-adrenoceptor agonist (LABA), and other drugs have limited therapeutic effects on COPD with significant individual differences. Traditional Chinese medicine (TCM)-modified Bushen Yiqi formula (MBYF) demonstrates advantages in management China. This study aims to evaluate the efficacy safety of MBYF as an add-on budesonide/formoterol patients confirm related genes affecting effect treatment COPD. Methods In this...