Electrical stimulation (ES) has been shown to promote nerve regeneration when it was applied the proximal stump. However, possible beneficial effect of establishing a local electrical environment between large defect on not reported in previous studies. The present study attempted establish defect, and examined its functional recovery.In study, conductive scaffold constructed used bridge 15 mm sciatic rats, intermittent ES (3 V, 20 Hz) an at site defect. Nerve recovery were after injury...

Triple-negative breast cancer (TNBC) is the most aggressive subtype of and lacks definite treatment targets. Tumor immune microenvironment (TIME) heterogeneity has a profound impact on immunotherapy response. Tumors with non-inflamed TIME derive limited benefit from immunotherapy. However, what drives formation in TNBC remains unclear.Using our multiomics database TNBC, we conducted an analysis to explore key genomic events driving TNBC. In vitro vivo studies further revealed potential...

Regulatory T cells (Tregs) heavily infiltrate triple-negative breast cancer (TNBC), and their accumulation is affected by the metabolic reprogramming in cells. In present study, we sought to identify cell-intrinsic modulators correlating with Tregs infiltration TNBC.Using RNA-sequencing data from our institute (n=360) Molecular Taxonomy of Breast Cancer International Consortium TNBC cohort (n=320), calculated abundance each sample evaluated correlation between gene expression levels...

To advance understanding of international students' psychological well-being and social-emotional experiences, we tested whether specific social influences could enhance belonging attenuate loneliness. Graduate undergraduate students (N = 126) from two universities in the United States participated a year-long study. Structural equation modeling analyses revealed that perceived support domestic fall predicted higher subsequent spring, while faculty lower loneliness spring. Perceived had an...

In recent decades, there has been a surge in the approval of monoclonal antibodies for treating wide range hematological and solid malignancies. These exhibit exceptional precision targeting surface antigens tumors, heralding groundbreaking approach to cancer therapy. Nevertheless, alone do not show sufficient lethality against cancerous cells compared chemotherapy. Consequently, new class anti-tumor medications, known as antibody-drug conjugates (ADCs), developed bridge divide between...

Abstract Background The aim of this study is to identify the potential pathogenic and metastasis-related differentially expressed genes (DEGs) in osteosarcoma through bioinformatic analysis Gene Expression Omnibus (GEO) database. Results expression profiles GSE14359, GSE16088, GSE33383, total 112 tissue samples 7 osteoblasts, were analyzed. Seventy-four normal-primary DEGs (NPDEGs) 764 primary-metastatic (PMDEGs) screened. VAMP8, A2M, HLA-DRA, SPARCL1, HLA-DQA1, APOC1 AQP1 identified...

Xanthomonas citri subsp. is the causal agent of citrus canker, which causes substantial losses in production. Here, we report role a polyketide cyclase (PKC) on virulence X. citri. The structure PKC was precisely predicted using Alphafold3. Promoter GUS fusion constructs and real-time quantitative reverse transcription (qRT-PCR) were employed to study pattern expression gene. A deletion mutation created explore metabolic change. determined have signal peptide,...

Abstract Traumatic injuries of the central nervous system (CNS) are followed by accumulation cellular debris including proteins and lipids from myelinated fiber tracts. Insufficient phagocytic clearance myelin influences pathological process because it induces inflammation blocks axonal regeneration. We investigated whether ligands nuclear receptor families retinoic acid receptors (RARs), retinoid X receptors, peroxisome proliferator‐activated lipid farnesoid increase phagocytosis murine...

Abstract Background Mast cells play important roles in the progression of various malignancies, but their prognostic value gastric cancer is unknown. Tryptase expression, as an indicator mast cell activity, was therefore evaluated to see whether this could be incorporated usefully into a nomogram after surgery patients with cancer. Methods Tissue microarrays from were created formalin-fixed, paraffin-embedded resection specimens. density assessed by immunohistochemistry, and association...

Abstract Background The purpose of this study was to investigate the value 18[F]-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in tailoring axillary surgery by predicting nodal response among patients with node-positive breast cancer after neoadjuvant chemotherapy (NAC). Methods One hundred thirty-three biopsy-confirmed metastasis were prospectively enrolled. 18F-FDG PET/CT scan performed before NAC (a second one two cycles baseline maximum...

Locoregional recurrent breast cancer indicates poor prognosis. No solid prediction model is available to predict prognosis and guide clinical management. Prior local treatment or systemic remains controversial.Locoregional patients operated in Fudan University Shanghai Cancer Center were enrolled as a training cohort. An external validation cohort included after locoregional recurrence from Ruijin Hospital, Jiaotong University. A nomogram predicting overall survival was established using...

Abstract Spinal cord injury (SCI) causes cell death and consequently the breakdown of axons myelin. The accumulation myelin debris at lesion site induces inflammation blocks axonal regeneration. Hematogenous macrophages contribute to removal debris. In this study, we asked how inflammatory state affects their ability phagocytose Bone marrow‐derived (BMDM) Raw264.7 cells were stimulated with lipopolysaccharides (LPS) or interferon gamma (IFNγ), which induce stress, endocytosis was examined....

Asthma is a severe chronic respiratory disease affecting all age groups with increasing prevalence. Anti-inflammatory strategies are promising options for the treatment of asthma. Although inhibitory effect aloin on inflammation has been demonstrated in various diseases, its asthma remains unknown.A mice model was established by treating ovalbumin (OVA). The effects and mechanism OVA-treated were determined enzyme-linked--immunosorbent serologic assay, biochemical examination, hematoxylin...

Abstract The scarce availability of water in highly populated cities is about to become a social problem. While the service companies work on improving distribution network order reduce losses, it evident that one main problems due an excess use this resource by users. This consumption relatively controlled when excessive clearly associated, consumer mind, with high costs. However, users are public places they tend consume because loss correlation In paper, we describe design device be...

Abstract Background To develop and validate a peritumoral vascular intratumoral radiomics model to improve pretreatment predictions for pathologic complete responses (pCRs) neoadjuvant chemoradiotherapy (NAC) in patients with triple-negative breast cancer (TNBC). Methods A total of 282 TNBC (93 the primary cohort, 113 validation 76 The Cancer Imaging Archive [TCIA] cohort) were retrospectively included. vasculature on maximum intensity projection (MIP) from DCE-MRI was segmented by Hessian...

Cavitation may quickly damage the surfaces of valve core and seat, causing noise, vibration problems. Different cavitation stages will affect regulating valve's flow characteristics to different degrees. Flow rate is one basic parameters in a hydraulic system, which innovatively used evaluate flow. By analyzing deviation ratio K between actual theoretical rate, flows are divided into four stages, dynamic behavior discussed using high-speed camera image processing technology. When zero, it...

A recent randomized controlled trial firstly demonstrated that cavity shaving significantly decreased the rate of positive margins and re-excision among partial mastectomy (PM) patients. However, it remains unknown whether should be routinely applied to Chinese breast cancer patients undergoing PM. total 408 PM 410 PMs 1796 surgically treated at Fudan University Shanghai Cancer Centre from January 2015 June were included in our study. Data analysed with univariate or multivariate analysis....