Yuan Zhao

ORCID: 0000-0002-8528-3147
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About
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Research Areas
  • Cancer-related molecular mechanisms research
  • Osteoarthritis Treatment and Mechanisms
  • RNA modifications and cancer
  • Spectroscopy Techniques in Biomedical and Chemical Research
  • Circular RNAs in diseases
  • Spectroscopy and Chemometric Analyses
  • Infrared Thermography in Medicine
  • RNA Research and Splicing
  • Ovarian cancer diagnosis and treatment
  • Protein Degradation and Inhibitors
  • Cancer Mechanisms and Therapy
  • Advanced Breast Cancer Therapies
  • Cancer, Lipids, and Metabolism
  • Sphingolipid Metabolism and Signaling
  • Endometrial and Cervical Cancer Treatments
  • Hepatocellular Carcinoma Treatment and Prognosis
  • Cardiovascular Disease and Adiposity
  • Stoma care and complications
  • Pressure Ulcer Prevention and Management
  • Laser Applications in Dentistry and Medicine
  • Reproductive Physiology in Livestock
  • Methemoglobinemia and Tumor Lysis Syndrome
  • NF-κB Signaling Pathways
  • 14-3-3 protein interactions
  • Plant-derived Lignans Synthesis and Bioactivity

Puer University
2022-2025

Kunming University of Science and Technology
2020-2025

Qingdao University
2024

Qingdao Municipal Hospital
2024

Beijing Shijitan Hospital
2024

Capital Medical University
2024

Weatherford College
2024

Shandong Provincial Hospital
2023

Shandong First Medical University
2023

Xinxiang Medical University
2022

Deep learning is usually combined with a single detection technique in the field of disease diagnosis. This study focused on simultaneously combining deep multiple technologies, fluorescence imaging and Raman spectroscopy, for breast cancer A number images spectra were collected from tissue sections 14 patients. Pseudo-color enhancement algorithm convolutional neural network applied to image processing, so that discriminant accuracy test sets, 88.61%, was obtained. Two different BP-neural...

10.1364/boe.394772 article EN cc-by Biomedical Optics Express 2020-05-27

Abstract Triple-negative breast cancer (TNBC) is highly malignant and lacks effective biotherapeutic targets. The development of efficient anticancer drugs with low toxicity few side effects a hotspot in TNBC treatment research. Although erianin known to have potent antitumor activity, its regulatory mechanism target not been fully elucidated, hampering further drug development. This study showed that can significantly inhibit cell proliferation migration, promote apoptosis, the growth...

10.1186/s12935-024-03332-2 article EN cc-by Cancer Cell International 2024-05-11

Objective: FOXP4-AS1 (FOXP4 antisense RNA 1) is putatively a functional oncogene in colorectal cancer. This study constructed regulatory network involving for better understanding of its function hepatocellular carcinoma (HCC). Methods: was assessed HCC and adjacent normal (control) liver samples via quantitative real-time PCR. Differentially expressed micro RNAs (DEmiRNAs) were predicted. Their target genes verified the gene expression profiling interaction analysis (GEPIA) database,...

10.2147/ott.s220923 article EN OncoTargets and Therapy 2019-08-01

The rapid developments of mobile communication and wearable devices greatly improve our daily life, while the massive entities emerging services also make Cyber-Physical System (CPS) much more complicated. maintenance CPS security tends to be difficult. As a "gamechanging" new active defense concept, Moving Target Defense (MTD) handle this tricky problem by periodically upsetting recombining connections between users servers in protected system, which is so-called "shuffle". By means,...

10.1109/dsc50466.2020.00065 article EN 2020-07-01

Background The fluctuation or even loss of estrogen level caused by menopause in women, and most gynecological cancers often occur before after menopause, so the age may be related to occurrence cancer. Aim To investigate whether at is independently associated with incidence analyze possible influencing factors. Methods We selected NHANES public database conduct study, excluding relevant factors, we finally included 5706 participants who had full data on gynecologic relationship between...

10.3389/fendo.2023.1218045 article EN cc-by Frontiers in Endocrinology 2023-11-16

Triple negative breast cancer (TNBC) is a highly aggressive illness that lacks effective targeted treatments. Although Erianin has shown potential antitumor properties, its precise mechanism of action and target in TNBC remain unclear, hampering the development drugs. The present study investigated underlying treating by using transcriptomics network pharmacology approaches. We evaluated Erianin’s bioactivity cell lines xenograft tumor models. results showed significantly inhibited...

10.18632/aging.205516 article EN cc-by Aging 2024-02-07

Measles is caused by measles virus belonging to genus Morbillivirus of the family Paramyxoviridae. Vaccination has played a critical role in controlling infection worldwide. However, recent years, outbreaks still occur many developing countries. Here, we report an outbreak among healthcare workers and 60 infected patients 50 were including doctors, nurses, staff, medics. Fifty-one (85%) tested positive for IgM antibodies against (83.3%) RNA. Surprisingly, 73.3% individuals had been...

10.1155/2016/1742530 article EN cc-by Canadian Journal of Infectious Diseases and Medical Microbiology 2016-01-01

Hepatocellular carcinoma (HCC) is a prevalent malignant tumor. Long non-coding RNAs (lncRNAs) have been demonstrated to be abnormally expressed in many tumors and act as crucial regulators various biological processes. However, the expression function of recently identified macrophage-associated lncRNA ELMO1 antisense RNA 1 (ELMO1-AS1) HCC are unclear.The ELMO1-AS1 was determined tissues adjacent nontumorous by quantitative real-time polymerase chain reaction (qRT-PCR). The Kaplan-Meier...

10.2147/ott.s213833 article EN OncoTargets and Therapy 2019-08-01

10.1016/j.saa.2020.118178 article EN Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy 2020-02-21

Abstract When a convolutional neural network (CNN) model was built, the size and resolution of its input data were fixed. However, Raman spectra collected by different spectrometers usually had length, intensity range, wavenumber interval between two adjacent points, which made existing CNN difficult to be applied new spectral set. Therefore, this paper proposed polynomial reconstruction algorithm as pretreatment method obtain reconstructed that would imported into with consistent interval....

10.1002/jrs.6268 article EN Journal of Raman Spectroscopy 2021-10-24

Introduction: Increasing evidence indicates that lncRNA TUG1 represents an oncogenic factor in cancer. But, the mechanisms by which contributes to lung adenocarcinoma (LAC) remain undocumented. Methods: The relationship between TUG1/miR-138-5p expression and clinical outcomes patients with LAC was indicated qPCR, FISH, TCGA cohort. Gain- or loss-of-function experiments vivo tumorigenesis were used assess role of LAC. interplay miR-138-5p validated luciferase gene report RIP assays. qPCR...

10.1177/20587384211048265 article EN cc-by-nc International Journal of Immunopathology and Pharmacology 2021-01-01

BACKGROUND Long non-coding RNAs (lncRNAs) have been shown to play an important regulatory role in many tumors. This study was designed investigate the expression of lncRNA ENST00000429227.1 hepatocellular carcinoma (HCC) and determine whether affects prognosis HCC. MATERIAL AND METHODS showing differences between M1 M2 screened by microarray measurements. Quantitative real-time PCR (qRT-PCR) used detect 161 HCC patients. The chi-square test evaluate relationship clinicopathological...

10.12659/msm.916551 article EN Medical Science Monitor 2019-08-31
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